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AN INVESTIGATION OF THE INTENSITY OF FREE RADICAL PROCESSES IN THE ORAL FLUID OF PATIENTS WITH PERI-IMPLANTITIS
As an inflammatory process, peri-implantitis stimulates metabolic disorders in soft and hard tissues and contributes to the development of oxidative stress. The purpose of this study was to study the intensity of free radical processes in the oral fluid of patients with peri-implantitis and to identify the optimal therapy for this condition. The research examines the oral fluid of 120 people diagnosed with peri-implantitis divided into 4 groups equally: group 1 – the control group; group 2 – patients with peri-implantitis therapy with boron preparations; group 3 – patients with peri-implantitis therapy with dimephosphone; group 4 – patients with peri-implantitis therapy with boron and dimephosphone complex. In order to assess the intensity of free radical oxidation in the oral fluid, the study determines the products of oxidative modification of biomolecules based on a quantitative assessment of the stained complex with thiobarbituric acid; the study also determines the flash maximum, and the area of H2O2-induced luminol-dependent chemiluminescence, and the concentration of malondialdehyde and diene conjugates using standard methods. The authors establish that therapy with boron preparations, dimephosphone and the complex use of boron and dimephosphone preparations contributes to the restoration of impaired oxidative homeostasis in the oral fluid; it is also found that complex therapy is the most effective.
Read MoreTHE EFFECTIVENESS OF KINESITHERAPY IN ORTHOPEDIC PATHOLOGY OF MAJOR JOINTS
The article aims to study the effectiveness of kinesitherapy in patients with coxarthrosis and gonarthrosis.
Materials and methods. The study involved 48 people with degenerative-dystrophic diseases of the hip and knee joints at stages I-II, 15 males and 33 females. The average age of men was 55.2 years, in women the average age amounted to 42.6 years. Clinically and radiologically, coxarthrosis was diagnosed in 18 people, while gonarthrosis was diagnosed in 30 people. The study proves the effectiveness of the course of kinesitherapy in orthopedic pathology of major joints by assessing the dynamics of pain syndrome, body mass index, and psychoemotional disorders.
Read MoreAN ANALYSIS OF THE OCCURRENCE OF SIGNS OF TEMPOROMANDIBULAR DISORDERS IN YOUNG PEOPLE
The current study explores the frequency of signs and symptoms of temporomandibular disorder (TMD), the effect of occlusive obstacles on the activity of masticatory muscles in young people with preserved dentition and the absence of somatic pathology. The authors find that in 90.6% of cases there were dysfunctional TMJ disorders with signs such as pain or stiffness in the head and neck (61.5%), sounds (squeaks, clicks, grinding) in one or both joints when chewing and opening the mouth (47.9%), otolaryngological manifestations, stuffy ears, tickling and burning in the throat, dizziness and tinnitus (26.0%).
Electromyography data on the activity of the masticatory muscles of patients with occlusive obstacles showed asynchronous contraction during “protrusion/retrusion” and “opening/closing”, increased electrical activity of the temporal muscle on the opposite side in the “right/left mediotrusion” sample, which was 111.5 mv ± 27.1. After the reconstruction of canine guidance, the tone of the temporal muscle on the opposite side of the pathology decreased to 75 mv ± 19.3 (p<0,05) The results obtained show a high prevalence of dysfunctional disorders in young people, the effect of occlusive obstacles on muscle tone and an increase in symptoms of TMD.
Read MoreADVANTAGES OF ACTIVE TACTICS OF ONGOING REGULAR MEDICAL CHECK-UPS IN PATIENTS WITH CARDIAC ARRHYTHMIAS AND CONDUCTION DISORDERS
The current article presents the results of active tactics of ongoing regular medical check-ups of patients with cardiac arrhythmias and conduction disorders.
The study involved the patients of the departmental polyclinic of the S.M. Kirov Military Medical Academy; in total, the study involved 545 people with heart rhythm and conduction disorders such as military personnel and those who previously served in the Armed Forces of the Russian Federation.
Patients with cardiac arrhythmia were actively monitored in the course of 2 years with monthly patient calls for an appointment with a cardiologist. For quality control, the study included 159 people without arrhythmia, who were observed traditionally, that is, they turned to a doctor on demand.
The study demonstrates that the frequency of hospitalizations for urgent indications, non-fatal cardiovascular complications, and deaths from cardiovascular causes in the course of 2 years was significantly lower in patients suffering from arrhythmias and monthly visits to the doctor compared with patients who were observed in traditional manner. The authors also establish that the decisive factors for the successful prevention of adverse cardiovascular events in actively observed patients with arrhythmias are more frequent correction of drug prescriptions, early detection of complications, as well as their timely prevention.
Read MoreEXPERIENCE IN THE TREATMENT OF COMBINED TRAUMA OF THE HEAD, CHEST, MUSCULOSKELETAL SYSTEM, PELVIS WITH THE DISTURBED PELVIC RING AND LONGITUDINAL FRACTURE OF THE SACRUM
Approaches to the treatment of combined trauma sometimes do not coincide with the generally accepted treatment scheme for individual injuries. Initially, the need to stabilize the patient and maintain vital functions comes to the fore. The features of catatrauma sometimes pose problems that are difficult to solve with the help of standard approaches, there can also be difficulties in forming the stages of treatment and technical difficulties with atypical injuries. The authors would like to present one of such unusual cases of concomitant injury and its treatment to the attention of specialists.
The aim of the study. To present a clinical case of a concomitant injury in which the final stage of treatment required the stabilization of the pelvic ring under conditions of a longitudinal fracture of the sacrum split during catatrauma.
The study examines the case of concomitant injury of the head, chest, limbs, spine, pelvis with damage to the pelvic ring with sacrum in a 14-year-old patient admitted to the hospital after a catatrauma, a fall from a height of 12 meters. Initially, the patient was in a terminal condition; at admission, a traumatic shock of the 3rd degree was diagnosed. At stage 1, the patient underwent external fixation of the limbs and pelvis in rod structures; after 8 days osteosynthesis of the bones of the lower legs with a plate and shoulder with elastic titanium rods was performed, and at the final stage, after a month and a half, the posterior pelvic semicircle and lumbar spine were fixed with a submerged U-shaped rod bent in several planes.
The patient was verticalized 5 months after the injury. The clinical outcome is positive. The patient walks independently, contractures have not formed, there are no disorders of the pelvic organs and no neurological disorders. There are no complaints except for the sensations of structures under the skin.
The method of choice for a sacral fracture may be the use of a transpedicular curved U-shaped rod structure that fixes the lumbar spine and the posterior semicircle of the pelvis.
Read MoreA STUDY OF GENDER DIFFERENCES IN MORPHOMETRIC PARAMETERS OF THE LOWER JAW (ACCORDING TO CONE-BEAM COMPUTED TOMOGRAPHY)
The article studies gender differences in the morphometric parameters of the lower jaws of people aged 31 to 57 years living in Krasnodar Krai by analyzing data obtained via cone-beam computed tomography. Gender differences in vertical dimensions have been established: general from the lower edge to the upper point of the alveolar arch; X-ray section above the maxillofacial line; X-ray section from the mandibular canal to the upper point of the alveolar arch; X-ray section from the mandibular canal to its lower edge; in the structure of the mandibular canal and its outlet. The obtained data on the morphometric characteristics of the mandible in people of this age period and can be used to determine the boundaries of the norm when conducting diagnostic studies in computed tomography departments in the orthopedic treatment of dentition defects using implants.
Read MoreANTIGENIC ACTIVITY OF THE VACCINE AGAINST PSEUDOMONOSIS IN PIGS
The article presents the results of studies of the antigenic activity of the vaccine against pseudomonosis in pigs developed by the staff of the Krasnodar Research Institute and еру federal state-owned enterprise “Armavirskaya biofabrika”. The authors study the antigenic activity in an experiment on pigs of various age and sex groups, in the reaction of agglutination in the blood serum of immunized animals with the determination of levels of antibodies to Pseudomonas aeruginosa antigens. The experiment finds that the vaccine against pseudomonosis in pigs has a high antigenic activity after double immunization of piglets aged 12-14 days with an interval of 10-12 days promotes the formation of intense immunity from day 14 for up to 6 months expressed in the levels of agglutinin titers from 3.2-4.6 to 4.0-5.8 log 2.
Read MorePHARMACOLOGICAL EFFECT OF VARIOUS DOSES THEANTIVIRAL DRUG “TRIAZAVIRIN” WHEN EXPERIMENTALLY ADMINISTERED TO CALVES
The aim of the study was to examine the subtoxicity of the antiviral drug “Triazavirin” when administered to calves. The experiment involved 60 Black Pied calves aged 15 to 60 days without clinical signs of diseases.
To experimentally test the harmlessness of the drug, two groups of calves were formed using the method of analogs, the age and live weight of the animals were also taken into account. All animals were kept in the same conditions and had the same diet based on their age. The first group of calves were administered a 500 mg dose of the drug, the second group – a 750 mg dose. To conduct an experiment on the study of chronic toxicity, the third group of calves was formed, the animals received a 500 mg dose of the drug orally, once a day, for 28 days.
The experiment on the harmlessness of the antiviral drug “Triazavirin” did not lead to a fatal outcome. Hematological blood analysis identified leukocytosis, lymphocytosis. Administering the drug causes inhibition of the function of the red bone marrow germ. Hemoglobin and hematocrit before and after the experiment do not reach the lower limits of physiological parameters. Biochemical blood analysis revealed signs of increased load on hepatocytes of the liver and the heart, the De Ritis ratio was increased. The drug reduces the level of immunoglobulins.
During the experiment on the study of chronic toxicity, there were no fatal cases observed. When analyzing hematological parameters, leukocytosis and thrombocytosis were noted. Prolonged administration of the drug leads to an increase in the load on the hepatobiliary system. Biochemical analysis of the composition of the blood serum of calves revealed signs of impaired protein metabolism and protein-synthesizing liver function, as well as led to thyroid depression and a decrease in the level of hormones T 3 and T 4. With prolonged use of triazavirin, immunosuppression of the body of experimental calves is observed.
Read MoreSEASONAL AND AGE DYNAMICS OF ASCARIASIS AND TRICHOCEPHALOSIS OF PIGS ON FARMS
Helminthiasis of farm animals is currently one of the most studied and problematic tasks of veterinary medicine. Among the helminthiasis of pigs, most authors report the most frequent detection of mixed infection of animals with ascarids, trichocephalus, esophagostoma. In order to carry out effective therapeutic and preventive measures for mono and mixed infection, it is necessary to study the epizootiological aspects of helminthiasis in specific climatшс фтв geographic zones. In connection with the above, the authors attempt to study the features of epizootiology, in particular, the seasonal and age dynamics of ascariasis and trichocephalus in pigs in a Rostov Oblast outdoor farm.
Read MoreSEROLOGICAL MONITORING OF AVIAN INFLUENZA VIRUS IN THE REPUBLIC OF MORDOVIA
Avian influenza is a viral, contagious, acute disease in wild and domestic birds. Mammals, including humans, can become infected with this disease. In recent years, the number of outbreaks of influenza virus, including highly pathogenic H5N1, has increased. In the Russian Federation, the influenza virus has moved to the first place among dangerous animal diseases.
New threats of pandemics and epizootics of avian influenza determine the importance of controlling the spread of this disease among animals and birds. The article presents current data on the epizootic situation of avian influenza in the Russian Federation and the Republic of Mordovia. Data on measures to prevent and control the spread of avian influenza are also analyzed.
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