Достижения в лечении рака с помощью БиАСО (бинарных антисмысловых олигонуклеотидов): стратегии двойного таргетирования для прецизионной онкологической терапии
Table 1 - Shows the key Features and Advantages of the biASO, Compared to conventional ASOs
Key feature | Advantage | Reference |
Enhanced specificity | The design nature of biASO which employs the 4WJ complex formation highly enhances its target specificity. According to Drozd et al. (2022) even a subtle sequence variation in the activator RNA (like a single base mismatch) can be readily discriminated by the biASO sensing module thus less background activation. | |
Improved selectivity | The marker-dependant activation greatly reduces the potential for unwanted gene suppression in healthy tissue lacking specific targeted makers hence minimizing system toxicity and side effects. | |
Tunability and Versatility | The modular design gives biASO flexibility tunability because the sensing module can be adapted to recognise a variety if RNA markers such as different cancer transcripts, and combinations of makers for increased specificity. |