Groups

Observation periods

Reliability of differences

Day 7

Day 14

180th day

Infiltrate thickness, µm

Control

175±25

-

-

P1*=0.04

P2*>>0.05

P3*>>0.05

With coating

125±25

-

-

Polymorphonuclear leukocytes,%

Control

52±8

30±5

-

P1*<<0.01

P2*=0.01

P3*>>0.05

With coating

-

12±3

-

Small lymphocyte type cells,%

Control

22±3

17±3

-

P1*<<0.01

P2*=0.08

P3*<<0.01

With coating

-

12±3

9±1

Histiocytes,%

Control

22±3

30±2

40±4

P1*=0.02

P2*=0.01

P3*<<0.01

With coating

37±7

7±1

-

Foreign body giant multinucleated cells (FBGCs)

Control

3±2

10±1

-

P1*<<0.01

P2*<<0.01

P3*<<0.01

With coating

-

-

-

Capsule thickness, µm

Control

-

200±30

90±10

P1*>>0.05

P2*=0.04

P3*=0.02

With coating

-

147±22

55±5