Groups

Observation periods

Reliability of differences

Day 7

Day 14

180th day

Infiltrate thickness, µm

Control

125±25

-

-

P1*=0.04

P2*>>0.05

P3*>>0.05

With coating

90±10

-

-

Polymorphonuclear leukocytes,%

Control

47±3

25±4

-

P1*=0.1

P2*=0.04

P3*>>0.05

With coating

42±3

17±3

-

Small lymphocyte type cells,%

Control

20±2

15 ± 2

-

P1*=0.1

P2*=0.04

P3*<<0.01

With coating

17 ± 2

10 ± 1

7±1

Histiocytes,%

Control

26±2

27±2

35 ± 3

P1*=0.08

P2*=0.02

P3*=0.004

With coating

22±2

17 ± 2

10 ± 2

Foreign body giant multinucleated cells (FBGCs)

Control

7±1

9±1

-

P1*<<0.01

P2*<<0.01

P3*<<0.01

With coating

-

-

-

Capsule thickness, µm

Control

-

175±35

70±10

P1*>>0.05

P2*=0.05

P3*=0.03

With coating

-

130±10

52±5