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Современные диагностические подходы к выявлению гепатопатий у производственных животных
Table 1 - Main pharmacokinetic parameters of caffeine clearance in animals of the control and experimental groups: C – control group; E – experimental group
Time after drug administration, h | Caffeine concentration, µg/ml | Total plasma clearance, ml·min⁻¹·kg⁻¹ | ||
C | E | C | E | |
1 | 7.35 | 7.20 | 1.52 | 2.32 |
2 | 6.28 | 6.23 | ||
3 | 5.78 | 5.48 | ||
4 | 4.69 | 4.78 | ||
5 | 3.98 | 3.86 | ||
6 | 3.25 | 3.30 | ||
8 | 2.91 | 2.84 | ||
10 | 2.46 | 2.53 | ||
12 | 1.73 | 1.78 | ||
18 | 0.81 | 1.23 | ||
24 | 0.37 | 0.52 | ||
based on the source [28]