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DOSE-DEPENDENT FEATURES OF CAFFEINE KINETIC CURVES IN URINE IN INDUCED TOXIC HEPATITIS
Table 1 - Urinary caffeine levels after exogenous caffeine administration
Administered dosage of the medicine (calculated as pure caffeine) | 50 mg/kg | 100 mg/kg | 150 mg/kg | |||
T after injection / sex of animals | ♂ | ♀ | ♂ | ♀ | ♂ | ♀ |
1 hour | 0,764± 0,053 | 0,802± 0,042 | 2,628± 0,174 | 2,573± 0,217 | 4,81± 0,23 | 4,46± 0,38 |
4 hours | 0,881± 0,037 | 0,904± 0,076 | 3,855± 0,319 | 3,721± 0,157 | 5,47± 0,38 | 5,15± 0,41 |
8 hours | 0,672± 0,064 | 0,693± 0,018 | 3,253± 0,126 | 3,452± 0,092 | 4,721± 0,641 | 4,854± 0,379 |