Possibilities of instrumental monitoring of Apixaban pharmacodynamics
Table 1 - The values of the measured characteristics of NPTEG by observation “points” in healthy volunteers after a single dose of 5 mg of Apixaban
Indicators | originally | 2 hours | 3 hours | 4 hours | 6 hours | 10 hours | 12 hours |
t1 (min.) | 1[0,8;1,8] | 1,3 [1,1;2,0] | 1,8 [1,3;2,1]* | 1,6 [1,1;1,9] * | 1,2 [1,5;3,1] | 1,1 [0,8;1,7] | 0,9 [0,7;2,0] |
ICC (r.u.) | 16[11;22] | 13 [11;18] | 14 [11;21] | 18 [15;22] | 15 [10;19] | 17 [11;20] | 16 [14;24] |
t3 (min.) | 8[7;10] | 11 [10;15] * | 13 [12;15] * | 15[14;17] * | 15 [14;16] * | 10 [9;12] | 6 [5;7]# |
TAC (r.u.) | 30[25;34] | 26 [25;34] | 23 [20;24] * | 15 [12;18] * | 20 [17;23] * | 27 [24;32] | 35 [29;40] # |
ICD (r.u.) | 32[30;35] | 29 [27;32] | 29 [26;33] | 22 [19;28] * | 30 [28;35] | 30 [27;34] | 31[27;35] |
t5 (min.) | 31[29;33] | 40 [30;48] * | 37[31;45] | 46 [41;50] * | 37 [30;48] | 34 [30;48] | 28 [25;34] |
МА (r.u.) | 560[490;610] | 530 [500;630] | 550 [490;600] | 430 [400;530] * | 450 [420;500] * | 550[480;600] | 590 [500;650] |
* - statistically significant differences from the initial values (p≤0.05 – changes in the hypocoagulation plan); # - statistically significant differences from the initial values (p≤0.05 – changes in the hypercoagulation plan)