ИЗМЕНЕНИЕ АКТИВНОСТИ ФЕРМЕНТОВ МЕТАБОЛИЗМА ГАМК У КРЫС, ПОДВЕРГНУТЫХ ВЛИЯНИЮ МОРФИНА В ПРЕНАТАЛЬНОМ ПЕРИОДЕ
Table 1 - Changes in the activity of GABA-related enzymes in various structures of the brain of rats exposed to morphine during organogenesis
Brain structures | Condition of the experiment | Parameters | 17 days | |
GAD (mkmol GABA/q.h) | GABA-T mkmol Glu/q.h | |||
Cortex of the cerebral hemispheres | Control | M±m | 71,72±4,35 | 77,46±3,54 |
2 mq/kq, 2 times a day | M±m | 89,65±5,72* | 64,30±3,68* | |
% | 125 | 83 | ||
10 mq/kq, 2 times a day | M±m | 39,45±2,56*** | 107,68±6,55** | |
% | 55 | 139 | ||
Cerebellum | Control | M±m | 85,24±5,70 | 82,38±4,78 |
2 mq/kq, 2 times a day | M±m | 125,30±7,15** | 52,72±3,60** | |
% | 147 | 64 | ||
10 mq/kq, 2 times a day | M±m | 40,92±2,64*** | 121,92±5,75*** | |
% | 48 | 148 | ||
Brain stem | Control | M±m | 59,75±2,56 | 70,65±3,42 |
2 mq/kq, 2 times a day | M±m | 82,46±4,38** | 51,57±2,40** | |
% | 138 | 73 | ||
10 mq/kq, 2 times a day | M±m | 38,84±1,85*** | 96,79±4,12** | |
% | 65 | 137 | ||
Hypothalamus | Control | M±m | 94,23±5,16 | 88,48±3,16 |
2 mq/kq, 2 times a day | M±m | 124,38±7,50* | 69,16±2,40** | |
% | 132 | 78 | ||
10 mq/kq, 2 times a day | M±m | 58,42±3,35*** | 117,68±5,68** | |
% | 62 | 133 | ||
M±m, n=5; * - p<0.05, ** - p<0.01, *** - p<0.001