СИНТЕЗ НОВЫХ ОРГАНИЧЕСКИХ ЛИГАНД С ПЕПТИДОВЫМИ СВЯЗЯМИ КОМПЛЕКСОВ LN(III) C НИМИ.

Аббасов М.Г.¹, Агеева С.А.², Меджидов А.А.³

^1,2,3Институт Химических Проблем Национальной Академии Наук Азербайджанской Республики

СИНТЕЗ НОВЫХ ОРГАНИЧЕСКИХ ЛИГАНД С ПЕПТИДОВЫМИ СВЯЗЯМИ КОМПЛЕКСОВ LN(III) C НИМИ.

Аннотация

Изучение роли хелатирующего агента органических лигандов, содержащих группы пептида в комплексообразовании  с трехвалентными лантанидами, играет роль важности в теоретической и прикладной химии сегодня [1,2]. Пептиды - важные органические соединения в жизни и деятельности чело-века, и также успешно используйте в качестве медицинских средств. Синтез и изучение таких веществ остаются одним из ведущих направлений в химии по сей день. С другой стороны получение  и изучение свойств комп-лексов Ln (III) с такими лигандами  дают нам дополнительную информацию о природе  координации редких земель.

Ключевые слова: комплексы лантаноидов(III), органические лиганды, пептиды.

Abbasov M. H.¹, Agayeva S.A.², Medjidov А.А.³

^1,2,3Institute of Chemical Problems NАN of Azerbaijan, mirheydara@mail.ru

THE SYNTHESIS OF THE NEW LIGAND WITH PEPTIDE GROUPS AND COMPLEXES LN(III) WITH IT

Abstract

Studying a role chelating agent of organic ligands containing peptide groups at complexing  with trivalent lanthanides plays the importance role in theoretical and applied chemistry today[1,2]. Peptides are important organic compounds in life and activity of the person, and also rather successfully use as medical means. Synthesis and studying of such substances remains  one of leading directions in chemistry to this day. On the other hand reception and studying of properties of complexes Ln(III) with such connections gives us the additional information on the nature of coordination communication of the rare earths.

Keywords: complexes  of the lanthanides(III), organic ligands, peptides.

Potentially heptadentate organic ligand, bis(1-phenyl-2,3-dimethyl-4-carbomoyl-5-on-pyrazoline)-2,6-pyridine(L) on the basis of pyridine-2,6-dikarboxylic acid (PDCC) and 1-phenyl-2,3-dimethyl-4-amino-5-оn-pyrazoline (АP) and some complexes Ln(III) with this ligand have been synthesized . Organical synthesis has been made with mixing PDCC and АP in mol relations 1:2 A reactionary mix pounded in a current of 20 minutes  with rotation, then heated up at 110-120^o  to definitive evaporation waters. Received the small crystallical substance was recrystallisized from ethy alcohol. T_mel.=345⁰. The Ln(III) complexes have been received by mixing of the ligand(L) and inorganic salts of Ln(III) in mol relations 1:1. Has been established that the coordination compounds have a general formula Ln(L)(Х)(H₂O)n, (where  Х-СН₃СОО^­, NO₃^­, SO₄^­, and  Br^­ ), n-2,3. The coordination numbers of the Ln³⁺ ions in the received complexes change from 10 to 11.

Fig.1

By means of the physical and chemical methods analysis, as elemental analysis, electronic spectroscopy, thermogravimetric and magnetochemisrty measuraments,  in particular by IR-spectroscopy, has been investigated the expected structure of the ligand НL and complexes Ln(III) with  this ligand. A middle absorbtion strip at 3456 sm^-1, we have carried to ν_NH valency vibration, which undergoes a high-frequency shift at complexing. In the high-frequency area due a trans-effect regulations of the molecule of ligand  also appears the second strip at 3240 sm^-1, which have widen and undergoes too at complexing . Besides in the middle field two new bands occur at 1672 sm^-1 and 1640 sm^-1, which we have made to the strip of Amid I. Strips of Amid II, which are formed overlaying ν_C-N and δ_NH valence vibrations (the highfrequency shift) are very weak and are not sufficiently  for identification. The absorption stirbs  overlapping of deformation δ_NH and δ_C-N vibration at 1296 sm^-1 and 1232 sm^-1 has been found.