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DOSE-DEPENDENT FEATURES OF KINETIC CURVES OF CAFFEINE IN URINE OF LABORATORY ANIMALS
Table 1 - Urinary caffeine levels after exogenous caffeine administration
Administered dosage of the medicine (calculated as pure caffeine) | 50 mg/kg | 100 mg/kg | 150 mg/kg | |||
T after injection / sex of animals | ♂ | ♀ | ♂ | ♀ | ♂ | ♀ |
1 hour | 0,825±0,17 | 0,846±0,12 | 2,415±0,39 | 2,487±0,51 | 4,45±0,79 | 4,512±0,84 |
4 hours | 0,42±0,08 | 0,39±0,05 | 3,132±0,22 | 3,151±0,27 | 4,87±0,53 | 4,76±0,62 |
8 hours | 0,205±0,03 | 0,175±0,07 | 2,61±0,19 | 2,57±0,11 | 4,061±0,31 | 4,23±0,27 |