ИЗМЕНЕНИЕ СОДЕРЖАНИЯ НЕКОТОРЫХ НЕЙРОТРАНСМИТТЕРОВ В ГОЛОВНОМ МОЗГЕ КРЫС, ПОДВЕРГШИХСЯ ВОЗДЕЙСТВИЮ МОРФИНА В ПРЕНАТАЛЬНЫЙ ПЕРИОД
Table 1 - Changes in the amount of GABA, Glu and Asp (μmol/g) in various structures of the brain of rats exposed to morphine during organogenesis (M±m, n=5)
Brain structures | Condition of the experiment | Indicators | 1 month | ||
GABA | Glu | Asp | |||
Cerebral cortex of the brain hemispheres | Control | M±m | 2.72±0.06 | 4.70±0.14 | 3.29±0.08 |
2 mg/kg, twice a day | M±m | 3.56±0.11*** | 3.53±0.12** | 2.63±0.10** | |
% | 131 | 75 | 80 | ||
10 mg/kg, twice a day | M±m | 1.77±0.05*** | 7.05±0.22*** | 4.90±0.14*** | |
% | 65 | 150 | 149 | ||
Cerebellum | Control | M±m | 2.40±0.07 | 5.07±0.16 | 3.10±0.07 |
2 mg/kg, twice a day | M±m | 3.24±0.15** | 3.65±0.14*** | 2.36±0.09*** | |
% | 135 | 72 | 76 | ||
10 mg/kg, twice a day | M±m | 1.42±0.07*** | 8.47±0.26*** | 4.74±0.11*** | |
% | 59 | 167 | 153 | ||
Brainstem | Control | M±m | 2.08±0.04 | 5.24±0.13 | 2.87±0.05 |
2 mg/kg, twice a day | M±m | 2.66±0.07*** | 4.09±0.13*** | 2.35±0.07*** | |
% | 128 | 78 | 82 | ||
10 mg/kg, twice a day | M±m | 1.39±0.05*** | 7.76±0.28*** | 4.16±0.14*** | |
% | 67 | 148 | 145 | ||
Hypothalamus | Control | M±m | 3.20±0.11 | 5.87±0.19 | 3.64±0.07 |
2 mg/kg, twice a day | M±m | 3.97 ±0.14** | 4.70±0.16** | 3.02±0.08*** | |
% | 124 | 80 | 83 | ||
10 mg/kg, twice a day | M±m | 2.24±0.10*** | 7.92±0.28*** | 5.02±0.15*** | |
% | 70 | 135 | 138 | ||
* – p<0.05, ** – p<0.01, *** – p<0.001