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MEDICINE

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ЭЛ № ФС 77 - 80772, 16+

OVERVIEW OF THE MAIN DIAGNOSTIC AND CORRECTION OF ERRORS AFFECTING THE EFFICIENT RELIEF OF PHYSICAL METHODS OF SYMPTOM COMPLEX «BACK PAIN»

Posted in 2013, Issue November 2013, MEDICINE | 0 comments

In the article the question associated with the progression of the static scoliosis of the spine and symptom complex «back pain» because of correctional and diagnostic errors, which in most cases lead to disability, despite the correctional treatment, supply of medicine and the latest diagnostic equipment. Shows how to overcome this deadlock is to improve the results of treatment to the maximum limit values 90-95% and to a lesser disability of population.

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E IDEMIOLOGY OF HEADACHE OF SCHOOLCHILDREN IN THE CITY OF SARANSK

Posted in 2013, Issue November 2013, MEDICINE | 0 comments

The article describes the prevalence of various headache forms of schoolchildren in the city of Saransk. To study this issue the frequency of occurrence, structure and expected causes of cephalgias has been investigated in schools, the assessement of whether the children had symptoms of neurotic depression and anxiety were also conducted. All these investigations allowed to make a conclusion about the influence of revealed violations on the students’ daily activities and achievements.

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IMPACT OF BRONCHODILATOR DRUGS ON THE VEGETATIVE HOMEOSTASIS IN CHILDREN WITH ASTHMA

Posted in 2013, Issue November 2013, MEDICINE | 0 comments

The aim of the study was to evaluate the influence of bronchiodialator drugs of different pharmacological groups on the state of the vegetative homeostasis in children during the period of exacerbation asthma. The method of spectral analysis cardiointervalogram conducted a study of changes in the autonomic nervous system against the background of inhalation of beta-2 adrenoagonists (fenoterol), anticholinergic (ipratropium bromide) and combined drug (fenoterol/ ipratropium bromide).

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MODERN ASPECTS OF THE ETIOLOGY OF PSORIASIS

Posted in 2013, Issue November 2013, MEDICINE | 0 comments

The article considers modern scientific data on etiology of psoriasis. Psoriasis is wide – spread disease, nevertheless scientists around the world continue to disputes about primary pathogenetic violations underlying psoriasis. Modern scientific data on etiology of psoriasis will be used in creating the most effective therapy of psoriasis.

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METHODS MULTIPARAMETER HEART RATE VARIABILITY ANALYSIS AT CORONARY ARTERY

Posted in 2013, Issue November 2013, MEDICINE | 0 comments

The article describes a method of multiparametric analysis of heart rate variability at coronary artery disease for the development of the algorithm of the device for home monitoring of the cardiovascular system.

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EFFECT OF COMBINED ANESTHESIA ON SYNCHRONIZATION OF ELECTROCARDIOGRAM AND PHOTOPLETHYSMOGRAM IN MINOR GYNECOLOGICAL OPERATIONS

Posted in 2021, Issue №3 (105) March 2021, MEDICINE | 0 comments

The aim of the research is to to study the aspects of synchronization between the subsystems of autonomic regulation of heart rate and pulse wave rhythm during ataractic analgesia and spinal block. Materials and methods. Electrocardiogram (ECG) and photoplethysmogram (PPG) signals recorded in the perioperative period in 15 women who underwent minor gynecological operations were analyzed using methods developed in modern nonlinear dynamics for complex, non-periodic signals. Signals were recorded of a single-channel ECG in the second limb lead and three PPG channels: from the right earlobe, the ring finger of the right hand, and the second toe of the right foot. Measurements were made on the day before the operation with the emitted behavior of patients and during the main stage of the operation and maintenance of anesthesia by spinal block and ataractic analgesia. The signals were digitized and filtered within the range of 0.05-0.15 Hz, which included the frequencies of neural regulation of heart rate variability and pulse wave rhythm. Results and conclusion. Through the evaluation of the nature of the interaction rhythms through the analysis of the dynamics of the phases of oscillations, the study establishes that spinal blockade disrupts connectivity rhythms regulation of the pulse wave (monitored via PPG) and heart rate (monitored through the RR intervals in the ECG) to a lesser extent than that of general anesthesia in the conception of ataractic analgesia. The relationship between the cardiointervalogram (CIG, a method for assessing the autonomic balance of the body by analyzing heart rate fluctuations during the recording of an electrocardiogram and performing a series of tests) and PPG, as the research demonstrates, depends on the distance between the location of the sensors on the body for monitoring through PPG and CIG: a more significant connection is observed when this distance decreases. As a result, the location of points in the CIG-PPG (ear) established the existence of a connection. In the KIG – FPG (leg) format, the connection was lost. The established facts can have both diagnostic and prognostic value in assessing the dysfunction of the circulatory system during combined anesthesia.

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MOLECULAR AND GENETIC ASPECTS OF EARLY DIAGNOSIS OF DIABETIC RETINOPATHY

Posted in 2021, Issue №3 (105) March 2021, MEDICINE | 0 comments

One of the many complications of such an endocrine disease as diabetes is diabetic retinopathy. This is the main cause of blindness in the working-age population of developed countries. As a rule, the severity of retinopathy depends on the duration of the course of diabetes, the concentration of glucose in the blood, and the level of blood pressure. The aim of the study was to examine the influence of genetic factors on the risk of developing diabetic retinopathy and to improve the effectiveness of predicting the development of this pathology using mathematical simulation. The study was conducted under the auspices of the T. I. Eroshevsky Samara Regional Clinical Ophthalmological Hospital as well as TestGen LLC and Dzhinkest LLC in the city of Ulyanovsk. The study involved 475 patients. Conclusions: Polymorphic loci of the VEGF genes rs2010963, AKR1B1 rs759853, ITGA2 rs2910964, ADRB3 rs4994, APOE rs7412, APOE 429358 that were observed independently of each other are not associated with the development of diabetic retinopathy in the group of patients with type 2 diabetes mellitus; however, taking into account the complex interallelic interactions of the VEGF, AKR1B1 and APOE genes allows for distinguishing unfavorable combinations of genotypes. Long-term diabetes and glycemia increase the likelihood of diabetic retinopathy. The combination of genes proposed in this study in combination with biochemical parameters increases the prognostic significance of the test system under development.

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DIAGNOSTICS OF THE PARAMETERS OF PSYCHOLOGICAL AND POLITICAL STABILITY IN THE CONTEXT OF INTERACTION WITH INFORMATION SOURCES

Posted in 2021, Issue №3 (105) March 2021, MEDICINE | 0 comments

The current paper presents the results of an empirical study conducted in 2020 that was aimed at studying the features of the interaction of today’s youth with various sources of information and their relationship with the parameters of psychological and political stability. As a result, the study identifies the general and specific factors of the interaction of the youth and adult group samples with sociopolitical information. The general factors are those of positive and critical evaluation of information, while the specific factors include the following: among young people, the factors of information activity and of political adaptability are observed, while among adults, these are the factors of political conservatism as well as those of trustworthiness of the social environment and virtual sources. The data obtained in the research allow the authors to expand the understanding of the peculiarities of the interaction of young people with various sources of sociopolitical information, the reasons for the negativization of the sphere of politics and the possibilities of integration into the current political system. The results obtained can be used to develop a strategy for presenting political information in modern media aimed at the current generation.

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THE EFFECT OF ISOLATED AND COMBINED ADMINISTRATION OF COBALT AND ZINC CHLORIDE ON THE PARAMETERS OF SYSTEMIC HEMODYNAMICS AND LIPID PEROXIDATION AGAINST THE BACKGROUND OF PREVENTIVE DOSES OF MELATONIN

Posted in 2021, Issue №3 (105) March 2021, MEDICINE | 0 comments

The aim of the study is to examine the characteristics of the effect of melatonin (“Melaxen”) on changes in the parameters of systemic hemodynamics and lipid peroxidation with combined and isolated administration of cobalt and zinc salts in various dosages. Melatonin was administered once daily at a dose of 10 mg/kg. Cobalt chloride (4 mg/kg) and zinc chloride (20 mg/kg and 1 mg/kg) were administered intragastrically using a probe. This procedure was conducted daily in the course of one month. At the end of the experiment, the authors investigated the functional state of the cardiovascular system. The study defines the main parameters of systemic hemodynamics: blood pressure was determined invasively by inserting a catheter into the femoral artery; cardiac output per minute was recorded using thermodilution. For this purpose, a thermistor was inserted into the aortic arch through the left common carotid artery. The average blood pressure, cardiac index, stroke index, and specific peripheral vascular resistance were calculated using special formulas. The parameters of lipid peroxidation were also studied.

The research demonstrates that excessive intake of toxic doses of cobalt and zinc chloride causes hypokinetic hypertension. With monthly intragastric prophylactic administration of melatonin and small doses of zinc (1 mg/kg), the study notes a protective effect on the development of hemodynamic manifestations of metal intoxication. Under the influence of zinc chloride in a small dose and melaxen, the level of lipid peroxidation indicators decreases and the activation of antioxidant defense enzymes occurs, which is most evident when they are combined in the conditions of the action of cobalt. The observed activation of lipid peroxidation processes and hemodynamic disturbances due to the action of metals as well as their weakening with the effect of the melatonin antioxidants and low doses of zinc suggest that there is a causal relationship between them.

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THE ROLE OF ULTRASOUND AND OTHER IMAGING DIAGNOSTIC METHODS IN THE DETECTION OF INFLAMMATORY BOWEL DISEASES IN CHILDREN

Posted in 2021, Issue №3 (105) March 2021, MEDICINE | 0 comments

Inflammatory bowel diseases (IBD) – a group of diseases with lesions of the intestinal wall of various degrees of severity of non-infectious specific genesis. Early onset of IBD in children, increased morbidity, low-specific character in the early stages of the disease, poor awareness of practitioners, severe course with high resistance to therapy and early urgent complications in children requires the search for an affordable, highly informative, non-invasive diagnostic method. In the study of modern domestic and foreign literature, imaging methods were considered: radiography with contrast, MRI, CT, colonoscopy, videocapsular endoscopy. These diagnostic methods have a number of contraindications and limitations, which complicates their widespread routine use in children’s practice. Ultrasound examination of the intestine – ultrasound) – a method that can be widely used in children, has no contraindications and restrictions, and the use of new, innovative methods-elastography-can significantly increase its diagnostic value in the detection of IBD.

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DYNAMICS OF THE PREVALENCE OF RESPIRATORY ALLERGIC DISEASES IN SAMARA OBLAST

Posted in 2021, Issue №3 (105) March 2021, MEDICINE | 0 comments

The aim of the current article is to study the dynamics of the incidence and prevalence of allergic rhinitis (AR) and bronchial asthma (BA) in Samara for a period of 5 years.

Materials and methods: the epidemiological indicators of the prevalence and morbidity of AR and AD were studied according to the outpatient visit data from 2014 to 2018.

Results. On average, the prevalence of AR and AD in Samara in the period from 2014 to 2018 is higher than similar values in Samara Oblast, the Volga Federal District the Russian Federation as a whole, amounting to 264.6 (p=0.009) and 1603.3 (p=0.0007) per 100 000, respectively. The greatest prevalence of AR and AD is typical for adolescents. The incidence of AR dominates among adolescents while the incidence of AD is prevalent in children under 14 years of age. Over the past 10 years, there has been a 26% increase in the prevalence of AD among children, 89% increase in adolescents, and by 2.1 times in adults while the prevalence of AR among children increased by 13%, among adolescents by 35%, and in adults decreased by 2.5 times.

Conclusions. Samara is characterized by high prevalence of AR and AD. There is a significant underdiagnosis of AR among the adult population, therefore it is necessary to further improve regional programs for the diagnosis, therapy, and prevention of this pathology.

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CONDUCTING A COMPREHENSIVE PSYCHOPHYSIOLOGICAL STUDY USING A POLYGRAPH AND BIOCHEMICAL METHODS IN EMPLOYEE SCREENING

Posted in 2021, Issue №3 (105) March 2021, MEDICINE | 0 comments

The current study presents the results of psychophysiological research of the sociopsychological reliability of employment candidates for working in special conditions during ability tests. The assessment of socio-psychological reliability includes a comprehensive set of examination procedures: a psychophysiological examination using a polygraph, which is currently a recognized method for detecting hidden information as well as biochemical blood testing before and after a polygraph test and psychological testing (personal questionnaires MMPI, 16PF). A psychophysiological study using a polygraph allowed the authors to identify a group that included people who abused alcohol as well as people who used narcotic and psychotropic substances without medical prescription. Compared with the individuals with no risk factors, the results of biochemical studies demonstrate significantly higher catecholamine levels in this group according to the adrenoreactivity of cell membranes, high enzyme activity gamma-glutamyltransferase (GGT), and significantly low scale values K,1,3, and significantly higher values of the L factor in 16PF. A comprehensive assessment of biochemical parameters, psychophysiological examinations using a polygraph, and psychological tests all contribute to improving the quality of determining the categories of occupational fitness during employee screening.

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MONITORING THE HEALTH STATUS OF CHILDREN IN ASTRAKHAN BASED ON THE RESULTS OF PREVENTIVE MAINTENANCE MEDICAL EXAMINATIONS

Posted in 2021, Issue №3 (105) March 2021, MEDICINE | 0 comments

The current article presents the results of a preventive examination of children aged 0-17 years in the course of a 3-year period. The study conducts an analysis of the coverage rates of the child population by professional examinations as well as health groups, the level and structure of morbidity. According to the monitoring results, there is a high level of coverage of children and adolescents in terms of preventive medical examinations. The first place among children of the Astrakhan region is occupied by diseases of the gastrointestinal tract, the second is occupied by the diseases of the endocrine system, and the third by the diseases of the musculoskeletal system. It is required to carry out continuous preventive and health-improving measures as well as forming motivation for a healthy lifestyle and hygiene education with maximum coverage of the child population.

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A COMPARATIVE ANALYSIS OF PHYSICOMECHANICAL PROPERTIES OF DENTURE BASE RESINS (A LABORATORY ANALYSIS) PART 2

Posted in 2021, Issue № 02(104) February 2021, MEDICINE | 0 comments

The search for new materials that would improve the physical and mechanical properties of denture base resin is highly relevant. This study aims to examine the physical and mechanical properties of photocurable resin for removable dentures. In order to examine the physical and mechanical properties of the resins, The study conducts laboratory tests of the photocurable resins (type 4) for SLA 3D printing using Denture 3D+, Dental Pink and Denture Base Resin while following the GOST technical standards. These tests lead the author to the conclusion that all the properties of these samples outperform those of the acrylic resins.

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STUDY OF HYDROPHILICITY AND FREE SURFACE ENERGY OF PHOTOPOLYMER RESINS IN A COMPARATIVE ASPECT

Posted in 2021, Issue № 02(104) February 2021, MEDICINE | 0 comments

Two main properties are responsible for the microbiological attractiveness of the surfaces of removable dentures: hydrophilicity and free surface energy. This study examined whether dentures made from photopolymer resin are more favorable for these surface properties than acrylic resins. The surface hydrophilicity and free surface energy of 50 standardized plastic specimens were determined by measuring the contact angle and surface tension. In both experimental setups, the surfaces of Ftorax, Rapid Simplified acrylics and Denture 3D +, Dental Pink and Denture Base photopolymer resins for SLA printing on a 3D printer were compared. These data were analyzed by ANOVA in conjunction with the Tukey test or the Howell test games. All photopolymer resin samples had lower average hydrophilicity and free surface energy than acrylic resins, with the exception of the Dental Pink designs. The surface properties of photopolymer resins for 3D printing make the surface of removable dentures less attractive for microbial colonization compared to acrylic resins.

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GALECTIN-3 AS A PROGNOSTIC BIOMARKER OF HEART FAILURE (A LITERATURE REVIEW)

Posted in 2021, Issue № 02(104) February 2021, MEDICINE | 0 comments

Due to the fact that cardiovascular diseases (CVD) occupy a leading place in the structure of mortality and disability of the population around the world, the search for new biomarkers for early diagnosis and prediction of CVD is a popular research area. One of the promising biomarkers of CVD, including heart failure (HF), is galectin-3. The current article contains a brief review of the current data on the biochemistry and physiology of galectin-3 and discusses in detail the possibility of using galectin-3 as a predictive biomarker in heart failure. The study conducts a detailed analysis of the results of modern experimental and clinical studies of the diagnostic and prognostic value of galectin-3 in heart failure.

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ASSESSMENT OF THE OPHTHALMOLOGICAL DISEASE INCIDENCE AMONG CHILDREN

Posted in 2021, Issue № 02(104) February 2021, MEDICINE | 0 comments

Impairment of the visual organ is a significant medical and social problem. The current study analyzes data from the primary medical documentation of the outpatient department of the State Medical Institution of the Astrakhan Oblast State Budgetary Healthcare Institution Children’s Municipal Polyclinic No. 3 for the period from 2017 to 2019 with the aim of identifying the trends in the prevalence of ocular pathology during childhood. Myopia, accommodation disorders, conjunctivitis, and retinopathy of prematurity occupy a leading position in the structure of ocular morbidity. The study identifies a tendency to increase the prevalence of visual pathology among children, indicating the need to optimize the early diagnosis, treatment and prevention as well as the promotion of preventive measures for the purpose of preserving the visual system. Studying and tracking of eye morbidity will allow for creating a database, on the basis of which a strategy for the development of the ophthalmological service can be developed.

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EPIDEMIOLOGICAL STUDY OF THE PREVALENCE OF BREAST CANCER IN STAVROPOL KRAI

Posted in 2021, Issue № 02(104) February 2021, MEDICINE | 0 comments

Ranked as the most common cancer type worldwide, breast cancer is a public health issue. The awareness of this nosology, public attention, and advances in breast imaging have had a positive impact on detection and screening. Breast cancer is a life-threatening disease and the main cause of death from malignant neoplasms among the female population.

Despite significant progress in the treatment of breast cancer over the past two decades, the prevalence and mortality of this disease maintain its concerning status. This prompts the authors of the article to conduct their own analysis of the incidence and mortality from breast cancer in Stavropol Krai, the North Caucasus Federal District, and the Russian Federation.

The aim of the study is to analyze the morbidity and mortality of patients with breast cancer among the population of Stavropol Krai. A comparative analysis of indicators of morbidity and mortality from breast cancer in Stavropol Krai, the North Caucasian Federal District, and the Russian Federation.

The materials and methods of the study include data analysis of official reporting forms, the database of the Stavropol Krai population cancer register and the federal state statistics agency. Study of the situation from 2013 to 2018.

Results: over a 6-year period in Stavropol Krai, the trend towards the spread of breast cancer, an increase in the specific weight in the structure of malignant neoplasms, and a high incidence rate among the female population can be observed. The incidence of breast cancer in the population of the Stavropol Territory is significantly higher than among the rest of the subjects of the North Caucasian Federal District. In comparison with neighboring Krasnodar Krai and Rostov Oblast, Stavropol Krai is below in terms of the morbidity and mortality. With a constant prevalence rate among the population of 61 years of age and over, this age group among the female population should be advised to regularly undergo medical examinations for the purpose of early diagnosis of breast cancer. Conclusion: this study allows for making a substantial evaluation of the prevalence, morbidity and mortality among patients with breast cancer in Stavropol Krai, the North Caucasian Federal District and the Russian Federation.

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THE EFFECT OF LOW ACCELERATION ON THE PARAMETERS OF LIPID METABOLISM IN TESTERS

Posted in 2021, Issue № 02(104) February 2021, MEDICINE | 0 comments

Astronauts, participants of long-term expeditions, have progressive changes in lipid and cholesterol metabolism during flights, which increases the risk of developing cardiovascular diseases long after the completion of missions. A promising means of prevention can be the creation of artificial gravity generated by a short radius centrifuge (SRC) on board of spacecraft and space stations. In this regard, the study of lipid metabolism under the influence of low-force accelerations created with the help of SRC presents great interest. The experiment involved nine men in the age range from 24 to 41, who were selected and signed an informed consent. The study used 3 rotation modes on the SRC with the direction of the head-to-pelvis acceleration (+Gz):1st – 2.1 g, 30 min, 2nd-2.4 g, 30 min, 3rd-2.9 g, 15 min. Each subject participated in all rotation modes. The interval between the first and second rotation amounted to 2 days, between the second and third — 3 days. Venous blood collection was conducted 7 days before the first exposure and within 10 minutes after each rotation. The study measured the concentration of cholesterol (CH), high-density lipoprotein CH, apolipoproteins A1 and B (ApoA1 and ApoV), and triglycerides in the blood serum. The study calculated the content of low-and very-low-density lipoprotein cholesterol, the atherogenicity index, and the ApoV/ApoA1 index.

At the 2.1 g acceleration, no significant changes in the determined parameters were observed. With an increase in the acceleration strength above 2.1 g, the lipid metabolism indicators first reflected the development of a stress reaction accompanied by the activation of lipolytic processes (2.4 g), then the formation of initial shifts in cholesterol metabolism of an atherogenic orientation in presence of lipolysis (2.9 g). All the detected changes occurred within the range of the physiological norm and characterized the course of adaptive processes.

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MONITORING THE USE OF DISINFECTANTS IN LIGHT OF HEALTH PROTECTION OF MEDICAL PERSONNEL

Posted in 2021, Issue № 02(104) February 2021, MEDICINE | 0 comments

The current article deals with the problem of the need for timely control of the correct dilution of working solutions of disinfectants. Solving this issue will increase the effectiveness of preventive and anti-epidemic measures in medical organizations against infections associated with the provision of medical services, which corresponds to the main strategy of the National Concept for the Prevention of Infections Associated with the Provision of Medical Care (2011). Preventing the emergence of resistance to the active substance of the disinfectant in strains of microorganisms is carried out through continuous monitoring of the resistance of microflora to the working solution used within the functional area. In the event of a deterioration in the health of employees of a medical organization associated with direct contact with the active substance of the disinfectant, it is necessary to conduct an investigation to determine the causes and errors made by employees during the interaction with the disinfectant. With the aim of monitoring the correct use of disinfectants, the study conducts a survey of junior and mid-level medical personnel of a multidisciplinary hospital.

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