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MEDICINE

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ПИ № ФС 77 - 51217, 16+

COMPARATIVE ANALYSIS OF INFLUENCE OF PARENTERAL NUTRITION METHOD ON METABOLISM OF PATIENTS WITH ACUTE SEVERE PANCREATITIS

Posted in 2019, Issue № 11(89) November 2019, MEDICINE | 0 comments

The authors analyzed the data on patients with severe acute pancreatitis (AP) who were treated during the period from 2014 to 2018. Nutritional support was started with full parenteral nutrition (FPN) for patients who showed symptoms of intestinal insufficiency on the second day of intensive care, which made it impossible to conduct early enteral nutrition. Depending on the type of mixture that was used as nutritional support, patients were divided into subgroups: subgroup No.1 (n = 22) included patients who received three-component mixtures in special bags for FPN. Subgroup No.2 (n = 20) included patients who received triple-component mixtures with increased content of ѡ-3 fatty acids for FPN. Subgroup No.3 (control) included patients (n = 25) who got FPN with separate modules of carbohydrates, amino acids, and lipids.

Conducting modular PN did not provide a protein-saving effect against the background of hypercatabolism caused by severe AP, was accompanied by an increase in the number of complications during the early phase of the disease (R = 0.797, p = 0.005) and an increase in the length of hospitalization (R = 0.643, p = 0.051).

The addition of ԝ-3 FA to the composition of mixtures in three-chamber bags for parenteral nutrition contributed to a more rapid restoration of the level of total protein, albumin, and blood glucose in the presence of severe AP (R = 0.783, p = 0.037).

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INFLUENCE OF PRODUCTION FACTORS ON THE STATE OF A MEDICAL SPECIALIST’S ORGANISM

Posted in 2019, Issue № 11(89) November 2019, MEDICINE | 0 comments

Организм медицинского работника находится в окружении неблагоприятных факторов производственной среды, под влиянием которых возможно развитие различных психофизиологических дисфункций. В данной статье был проведен анализ напряженности труда медицинских работников нескольких больниц г. Санкт-Петербурга с выявлением у них психосоматических патологий. На основании полученных результатов было сделан вывод о том, что сотрудники обследованных больниц в средней степени адаптированы к стрессовым воздействиям на свой организм.

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PREVALENCE OF IODINE DEFICIENCY STATES IN SCHOOL CHILDREN

Posted in 2019, Issue № 11(89) November 2019, MEDICINE | 0 comments

Currently, the problem of iodine deficiency remains very significant, which is associated with a high degree of its prevalence, a wide range of manifestations and consequences, especially among children who are most vulnerable. This article presents key questions on the role of iodine and thyroid hormones in the functioning of the body and the consequences of iodine deficiency. The spectrum of iodine deficiency pathology is presented, data on the prevalence of iodine deficiency states of children and adolescents and the methods used in the course of work are highlighted. The study was conducted among school-aged children (from 7 to 12 years old) who underwent treatment at the Lastochka Sanatorium in Izhevsk. We used the technique developed by Khlebnikova L.N. – a table with indicators and a diagnostic coefficient (DC) – to identify the risk group.

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INKRETINOMIMETIKS: LOOK AT THE EFFICACY AND SAFETY

Posted in 2014, Issue April 2014, MEDICINE | 0 comments

The article examined and compared the performance of two groups of hypoglycemic drugs and inkretinomimetikov biguanide, as well as their impact on the body mass index (BMI), to evaluate the likelihood of one of the possible side effects – acute pancreatitis. When credible evidence of efficacy inkretinomimetikov particularly exenatide, its positive impact on the reduction of BMI and the lowest probability of acute pancreatitis, will allow the most widely used in the preparation of this group for the purpose of effective and safe control of type 2 diabetes by obesity.

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INTENSITY THE EXPRESSION MARKERS OF ACTIVATION LEUKOCYTES AT INTRODUCTION B. ABORTUS 19 BA

Posted in 2014, Issue April 2014, MEDICINE | 0 comments

The assessment of intensity an expression markers activation of leukocytes of experimental biomodels is carried out, at immunization B. abortus 19 BA. The increase in intensity an expression of receptors IL – 2 and IL – 4 on population monocytes and neutrophils during the period from 5 to 14 days after vaccination against a brucellosis is established. Considering the leading role an anti-gene – presenting cages in an initial stage of immunogenesis, detection of intensity of an expression of receptors to IL 2 and 4 allows to define a functional condition of phagocytes in response to immunization, and respectively can act as a marker at an assessment of efficiency actions for specific prevention a brucellosis.

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METHODICAL PROBLEMS OF CHEMICAL AND ANALYTICAL SAFETY OF PRODUCTS GROWN WITH APPLICATION OF DITHIOCARBAMATES

Posted in 2014, Issue April 2014, MEDICINE | 0 comments

The article presents the results of the research of the significance of biodegradation ethylene-bis-dithiocarbamate formulations with the formation of ethylenethiourea in agricultural products (grapes, cucumbers, onions, potatoes, tomatoes) and some processed products.

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SOCIAL ORPHANHOOD – THE REALITIES OF MODERN LIFE

Posted in 2014, Issue April 2014, MEDICINE | 0 comments

The article is devoted to the problem of social orphanhood in modern society. Based on the data of statistics revealed the main reasons and factors contributing to the fact that children with living parents live in orphanages and other specialized institutions. Analyzed further destiny and features individual development of these unhappy children. Some positive dynamics in solving the problem is showed. In considering the situation in the Volga Federal district. Effectiveness of active social orphanhood prevention, its main areas and the need for further improvement.

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METHOD NONSPECIFIC ANTICYTOKINE THERAPY OF GENERALIZED FORMS OF SURGICAL INFECTIONS

Posted in 2014, Issue April 2014, MEDICINE | 0 comments

The results of the clinical use of pentoxifylline as a nonspecific anti-cytokine therapy of generalized surgical soft tissue infections. In a comparative analysis, proved to be efficient for Pentoxifylline suppression of the synthesis and the reduction of TNF levels, which option enabled affect the course of infection and shorten cupping systemic inflammatory response.

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IMAGING OF THE TEMPORAL BONE: LITERATURE REVIEW

Posted in 2014, Issue April 2014, MEDICINE | 0 comments

The question of choosing the optimal method and visualization techniques of temporal bone is relevant because resulting from the survey information allows to decide on further conservative or operative treatment strategies and their content. The paper is made of the history of the temporal bone imaging, defined modern realities, outlined the prospects; formulate conclusions regarding the choice of methods and means of temporal bone imaging in various pathological conditions.

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FEATURES OF CLINICAL COURSE AND PROBLEMS OF SYSTEMATIZATION OF PSYCHOLOGICAL SYNDROMES IN CASE OF ORGANIC MENTAL DISORDERS

Posted in 2019, Issue № 10(88) October 2019, MEDICINE | 0 comments

This review article discusses the problem of systematization and features of the clinical course of organic mental disorders. The views of a number of authors on characteristic psychopathological syndromes in this group of diseases are presented. Characteristic features of some organic mental disorders are grouped and studied. The necessity for further work in the field of systematizing the clinical features of the manifestations of organic mental disorders in various nosological groups of diseases is identified and justified.

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STUDY OF THE RELIABILITY OF PRE-LABORATORY DIAGNOSTIC METHODS IN CASE OF CHRONIC VAGINITIS

Posted in 2019, Issue № 10(88) October 2019, MEDICINE | 0 comments

The article contains a comparative study of the severity of inflammatory processes in women with chronic vaginitis regarding complaints of patients and visual manifestations of chronic vaginitis as the main methods of pre-laboratory diagnosis. Results of surveys of patients with chronic inflammatory processes in the lower reproductive tracts are presented. Comparative assessment of the level of leukocytes during the microscopy of wipe samples and visual manifestations of chronic vaginitis is carried out.

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OPPORTUNITIES AND DEVELOPMENT PROSPECTS FOR RADIATION DIAGNOSTICS OF CARDIOVASCULAR DISEASES OF THE REPUBLICAN HOSPITAL NAMED AFTER N.A. SEMASHKO IN THE REPUBLIC OF BURYATIA

Posted in 2019, Issue № 9(87) September 2019, MEDICINE | 0 comments

Cardiovascular diseases are the leading cause of population death; therefore, the diagnosis and detection of these diseases are of great importance for timely treatment and improvement of prognostic data. Radiation diagnostics has a special place in the volume of cardiological and cardio-surgical care.

Republican Clinical Hospital named after N.A. Semashko provides high-tech medical care. This article analyses data on the use of radiation diagnostics in cardiology of the Republican Clinical Hospital named after N.A. Semashko and provides a review of recent developments in non-invasive diagnostics of cardiovascular diseases describing the prospect of their implementation.

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COGNITIVE DISORDERS OF PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS

Posted in 2019, Issue № 9(87) September 2019, MEDICINE | 0 comments

The authors have conducted a comparative screening analysis of cognitive dysfunctions among patients aged 35-45 years with type 1 and type 2 diabetes mellitus. Cognitive impairment are more often found in patients with type 2 diabetes mellitus, and this was due to an increase in the proportion of predemental moderate cognitive impairment. Type 2 diabetes mellitus is characterized by a predominance of cognitive dysfunctions in men, due to mild and moderate cognitive impairment, in the amount observed two times more often than in women. However, in women with type 2 diabetes mellitus, cognitive disorders were not detected in 52% of cases, which is 2.6 times more often than in men.

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FEATURES OF USING STEVIA IN FUNCTIONAL NUTRITION FOR TYPE 2 DIABETES MELLITUS

Posted in 2019, Issue № 9(87) September 2019, MEDICINE | 0 comments

The article discusses the results of the latest research carried out by the scientists on the use of plant extract of stevia in nutrition for type 2 diabetes mellitus. The author of the article focuses on the positive and negative properties of the stevioside sweetener while indicating possible side effects. The study also discusses risk factors for developing type 2 diabetes mellitus, as well as antidiabetic, antihyperlipidemic, antiplatelet, angioprotective, antimicrobial and antihypertensive effects of stevia extract, outlines the need for further research on the effect of stevia on weight loss.

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PREGNANCY AND CHILDBIRTH OF PREGNANT TEENAGERS UNDER MODERN CONDITIONS

Posted in 2019, Issue № 9(87) September 2019, MEDICINE | 0 comments

Pregnancy and childbirth in primiparous adolescents is a serious obstetric problem since the amount of complications is much higher than in pregnant women over 18 years of age. Later appeal for registration for pregnancy, irregular visits, and a high frequency of hypochromic anemia are typical in the group of adolescents. The leading complication in childbirth is the weakness of the labor force and discoordinated labor activity, which are indications for surgical delivery in this group. The postpartum period is marked by an increased frequency of hypotonic bleeding.

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FORECASTING LACTATION DISTURBANCES BY PLACENTA HOR-MONE LEVEL AFTER IN VITRO FERTILIZATION

Posted in 2019, Issue № 9(87) September 2019, MEDICINE | 0 comments

A study was made of the possibility of forecasting lactation disturbances by the level of placental hormones in women after in vitro fertilization (IVF) and embryo transfer (ET) depending on the form of infertility in a single-term, full-term pregnancy. The studies were carried out in three subgroups with tubal-peritoneal, endocrine, and male infertility factors, which were compared with an independent pregnancy. We assessed the hormonal function of the placenta, revealed a high frequency of compensated placental insufficiency in the IVF group. In the subgroups, there was a decrease in the production of placenta hormones (progesterone, estriol, placental lactogen) preparing the mammary glands for lactation, which was reflected in a decrease of normal lactation by 5 days in all subgroups. It is concluded that the increased incidence of lactation (hypogalactia) in the first two weeks after birth is associated with a decrease in the hormonal function of the placenta.

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COMPARISON OF THE FREQUENCY OF FOCAL ENAMEL DEMINERALIZATION DEPENDING ON THE TIME OF TREATMENT AND THE USE OF REMOVABLE AND FIXED ORTHODONTIC APPLIANCES

Posted in 2019, Issue № 9(87) September 2019, MEDICINE | 0 comments

It is established that qualitative and quantitative changes in the composition of mixed saliva occur in the early stages of orthodontic treatment, while at the same time the isolation of an enameled area takes place, which impedes remineralization. There is a lack of knowledge concerning the occurrence of caries in the spot stage during orthodontic treatment on removable and fixed appliances, as well as the correlation of demineralization with the time of wearing the device. We conducted comparative analysis of the frequency of occurrence of focal demineralization of enamel when wearing removable and fixed appliances and determined its dependence on treatment time. For the study, 5 groups of patients were formed according to the type of appliances used and the time of use, whereas the first group did not use any orthodontic appliances and was a control one. The highest prevalence of carious enamel lesions in the fixation area of the apparatus was detected in the group with fixed orthodontic constructions worn for two years or more. The smallest damage to the enamel was observed in the group with removable orthodontic appliances worn up to a year and a half. Despite the differences, when using any of the types of orthodontic appliances we recommended remineralizing therapy or treatment of superficial caries with the indicated infiltration method after the completion of the treatment.

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MEDICAL AND STATISTICAL ASPECTS OF OPHTHALMOLOGICAL HEALTH OF WORKING RAILWAY PERSONNEL

Posted in 2019, Issue № 8(86) August 2019, MEDICINE | 0 comments

The article presents materials based on the study of the ophthalmological health of Russian railway personnel (102 people in total) working on railroads rolling stock: 42.0% in locomotive crews, 29.0% in servicing rolling stock mechanics, and 29.0% in other positions providing the movement of trains.

During the study, a set of special techniques was used: Schirmer 1 test to assess the tearing; the method of eight consecutive tests (with glasses and without glasses) on the “Mesotest-2” apparatus for the study of mesopic (twilight) vision. For the subjective assessment of vision and asthenia, an ES-20 questionnaire and the MFI-20 test were applied.

As a result of the study, a number of medical and statistical features of the ophthalmological health of working railway personnel were discovered, which enabled the planning of a complex of treatment and preventive measures implemented later under the conditions of the Interdisciplinary Centre for Eye Microsurgery of JSC Russian Railways with regard to the narrow professional affiliation of employees.

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THE AFFECTIVE DISTURBANCE IN PEOPLE WITH ALZHEIMER’ AND VASCULAR DEMENTIA

Posted in 2019, Issue № 8(86) August 2019, MEDICINE | 0 comments

Introduction: The evaluation and treatment of affective symptoms in the people with dementia have an important role in the engagement in daily activities, relationships and the quality of life for them and their families.

Objective: Our aim was to evaluate Affective Disturbance in people with Alzheimer’s (AD) and vascular dementia (VD).

Subjects and Methods: We assessed the scores of the Affective Disturbance Subscale of the BEHAVE-AD in 30 people with AD and 30 people with VD, scoring 0-3 based on severity rating of the symptoms.

Results: The Affective Disturbance was present in 86% of people with vascular dementia and in 36.6% in people with Alzheimer’s dementia.

Conclusion: An understanding of mood symptoms in people with AD can aid in planning appropriate pharmacological and nonpharmacological treatment and also to help in giving appropriate advice to caregivers.

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DYNAMICS OF HOMEOSTASIS INDICATORS IN PATIENTS WITH ACUTE PANCREATITIS DEPENDING ON THE METHOD OF NUTRITIONAL SUPPORT

Posted in 2019, Issue № 8(86) August 2019, MEDICINE | 0 comments

We examined and treated 82 patients with severe acute pancreatitis (AP) – the choice of the method of nutritional support depended on the functioning of the gastrointestinal tract. The first group included patients (n = 37) with severe AP, who, on the 2nd day of intensive care, still had the manifestations of intestinal insufficiency, and, therefore, underwent full parenteral nutrition with three-component bags. The 2nd group included patients (n = 45), who underwent early enteral nutrition through a nasogastroduodenal probe since 2 days of the course of the disease. Beginning with 3rd day, energy requirements were covered by the combined PN and EN method.

Stress-induced hyperglycemia and hypoproteinemia developed during the first days of the disease in patients with severe acute pancreatitis. Normalization of the level of glycemia and average values of the total blood protein passed more quickly against the background of combined enteral and parenteral nutrition, which enabled achieving the target calorie content (25 kcal/kg) and a protein dose of up to 1.5 g/kg on the 5th day of nutritional support.

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