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MEDICINE

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ЭЛ № ФС 77 - 80772, 16+

ASSESSMENT OF NEW PYRIMIDINE DERIVANTS HEMOTOXICITY

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

All new compounds perspective for making medicine must undergo pre-clinic estimate, including mandatory toxicity assessment. Thus, the research assesses new pyrimidine derivants compounds. Materials and methods. The research was conducted on 60 species of 10-month-old male rats. They were divided into groups (n=12): control group intragastrically received equivalent volume of distilled water; subject group received pyrimidine compounds suspended in distilled water under lab codes of VMA–13–06; VMA–13–11; VMA–13–12; VMA–13–13 in 1/10 dosage of molecular mass (39, 24, 24, 27 mg/kg, respectively) over the course of 60 days. Hemotoxicity assessment was based on clinical blood test of animals with cell-color ratio and leucogram. Results. It was established that injection of VMA-13-11 and VMA-13-13 pyrimidine compounds does not effect blood cell count, Hb level, color ratio and leucogram. Injection of VMA-13-06 and VMA-13-12 compounds causes anemia, leukocytopenia and makes different white cells percentage shift to the right. Conclusion. Research of hemotoxicity shows that pyrimidine derivants under lab codes of VMA-13-11 and VMA-13-13 do not affect red and white hematopoietic lineage, while compounds VMA-13-06 and VMA-13-12 have hemotoxic effect.

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COMPREHENSIVE ASSESSMENT OF CARDIOVASCULAR DISEASES RISK FOR TEENAGERS LIVING IN THE TERRITORY OF STAVROPOL TAKING INTO ACCOUNT MORPHOLOGICAL, HEMODYNAMIC AND LIPOID METABOLISM RATES

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

The conducted complex analysis of the main morphological rates, parameters of hemodynamics and lipoid metabolism among teenagers, show the presence of a peculiar individual morphofunctional status. 59.4% of girls and 53.2% of boys had normal body weight. Overweight teenagers predominate among boys (18.6%). Both groups (2.3% of girls and 4.0% of boys) have I degree obesity, and 1.5% of girls have II degree obesity. In the boys group, there is a tendency to increased level of cholesterin. 89.5% of boys and 92.5% of girls had ABP within normal age limits. Nevertheless, 8.9% of boys and 6.8% of girls have a normally high ABP rate. The ABPI data obtained in most cases reflect normal vascular rigidity in both groups of teenagers. However, 10.5% of girls and 6.4% of boys are at a very high risk of developing cardiovascular pathology. The multidimensional correlation analysis of the studied rates in the teenage groups shows a positive link between the weigh and height index and the main hemodynamics rate and atherogenic lipoproteins.

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TERATOGENIC EFFECT OF DRUGS ON EMBRYONIC FETAL DEVELOPMENT

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

The issues of the influence of drugs on the embryonic development of fetuses continue to remain quite relevant today.

The modern scientific and medical community of today has a lot of information about the effect of various drugs on the fetus, but it is still clearly insufficient to be sure of conducting optimal and safe pharmacotherapy in pregnant women. The ongoing COVID-19 pandemic and the use of new antiviral vaccines have exacerbated the general problem of the effect of drugs on the course of pregnancy and fetal health. Unfortunately, there are currently insufficient statistics on the use of these vaccines during pregnancy, which limits the ability of doctors to use them without compromising the health of the mother and her unborn child. At the same time, aggressive advertising, advice from non-professionals, popular medical literature, which is not always professional, are used by pregnant women to choose and take medications during pregnancy, often without thinking about what harm the medicine used can cause to the health of the mother and her unborn child [1]. Pediatricians have repeatedly drawn attention to the problem of the effect of drugs on the embryonic development of fetuses. But the recent appearance of new drugs: antitumor antibiotics, drugs for the treatment of oncology, anti-inflammatory drugs and vaccines for the treatment of viral diseases have again attracted the attention of doctors to the health of pregnant women and their fetus. The problem of drug teratogenesis, which began with the thalidomide scandal, still remains relevant. Today, the safety of pharmacotherapy is being given significant importance, which certainly has a significant priority in the treatment of pregnant women. The use of modern diagnostic techniques allowed doctors to predict the development of the embryo and the effect on it of drugs used during pregnancy in more detail. In this review, the authors attempt, using mainly domestic literature, to focus the attention of interested parties on the negative factors and consequences of the use of certain drugs, in particular, antibiotics, nonsteroidal anti-inflammatory drugs and their analogues on fetal development and the health of mothers and their children.

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INFLUENCE OF VARIOUS FACTORS ON THE DESIRE TO LEAVE MEDICINE OF MEDICAL STUDENTS, RESIDENT PHYSICIANS AND DOCTORS

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

Physical, emotional, mental pressure and work stress are inextricably linked to burnout symptoms and thoughts of leaving the profession. It should be noted that not only constant stress at work/school negatively affects the desire to leave, but there is also a lack of free time, inability to spend it with loved ones, as confirmed by earlier studies [1], [5], [6].The relative risk of intensified burnout symptoms and frequent thoughts of leaving was the highest in case of work-life imbalance. The burnout of doctors is a universal dilemma faced by medical personnel, especially doctors, characterized by emotional exhaustion, depersonalization and feeling of low personal fulfillment. This is one of the main reasons for leaving the profession [2], [4].

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EPIDEMIOLOGY OF GASTRIC MALIGNANCIES IN THE REPUBLIC OF MORDOVIA

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

Worldwide, 1,000,000 people are diagnosed with gastric cancer every year. In the Russian Federation, the incidence of gastric cancer is comparatively lower than in the countries of the Asia-Pacific Region, but the one-year mortality rate mortifying, reaching 49.8 per cent. Positive outcomes are noted in the timely treatment of gastric cancer, in case of a metastatic lesion of regional lymph nodes 5-year survival reduces to 8-30%. Often, such situation could be due to the tendency of a steady increase in morbidity, the late admissions of patients, and therefore, the delay in diagnosis, these aspects have, in fact, prompted us to conduct this study. Purpose of the study: To analyze the morbidity rates, as well as the indicators of one-year fatality from gastric cancer in the Republic of Mordovia from the period of 2015 to 2020. For the period from 2015 to 2020, we have noted a tendency of decrease in the incidence of gastric cancer in the territory of the Republic of Mordovia. Despite the improvement of diagnostic abilities, as well as high-tech medical equipment, the introduction of innovative treatment methods, the proportion of patients with GC who have the disease at an early stage, is statistically still low. According to the statistics of gastric morbidity for the period from 2015 to 2018 in the RM, only 30,82±4,27% of patients at the III stage sought help, patients at the IV stage – 36,5±1,2%, this tendency is generally the same in the Volga Federal District. Over the five-year period, the rate of decrease of one-year mortality in Moldova was 33.75+8.44%.

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CLINICAL AND EPIDEMIOLOGICAL ASPECTS OF CHILDREN SUFFERING FROM ASCARIDOSIS IN THE ASTRAKHAN OBLAST IN 2011 – 2020

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

Aim of the work. Research clinical and epidemiological situation with children suffering from ascaridosis in the Astrakhan Oblast in 2011 – 2020.

Materials and methods. 345 epidemiological medical files of people infested with ascarids for the period of 2011 – 2020 were analyzed.

Research results. Cases of ascaridosis were mainly registered among children living in the rural areas of the Astrakhan Oblast – 73.0% (n=149), 1.3% of them (n=2) were children under 1 year old. Among these cases, one infested 9-month-old (male) was registered in 2013, living in the Akhtubinsky District of the Astrakhan Oblast, and one 10-month-old (female) in 2019, living in the CATU of Znamensk city. There were no cases registered among children in the same age group in other districts of the Astrakhan Oblast.

Besides rural areas, cases of ascaridosis were registered among children living in city areas – 27.0% (n=55), including children in the age groups of 1–7 years – 65.5% (n=36), and 7 – 17 years – 34.5% (n=19).

The majority of infested children expressed various complaints – 67.2% (n=137). 26.3% (n=36) complained about parasite emersion during defecation. Some children had no complaints – 48.9% (n=67).

After being diagnosed, 99.0% of patients (n=202) were treated with such drugs as “Pyrantel” and “Albendazole”.

Conclusion. Cases of ascaridosis are registered in all age groups, the most common being preschool children (1 – 7 years old), which is linked to their poor hygiene. Ascaridosis among children under one can be linked to a possible infestation in their families due to poor hygiene of adults. The most common clinical symptoms were epigastric pain, nausea, appetite loss, diarrhea. The most common factors of ascarid infestation among children were poor hygiene, unwashed vegetables and fruits consumption, habit of eating without prior handwashing. Emersion of Ascaris lumbricoides male during defecation together with negative feces test point to the absence of Ascaris lumbricoides female inside the macroorganism, therefore further treatment is not required.

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ROLE OF GENETIC FACTORS IN FETAL GROWTH RETARDATION

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

In modern medicine, increasing attention is being paid to the problems diagnosed during pregnancy, which significantly increase the risk of complications and adverse outcomes of pregnancy and childbirth, as well as the entire life course of both newborn and mother [9, C 13-14]. To this day, fetal growth retardation is one of these pressing problems in obstetrics and perinatal medicine as well as pediatrics [2].

According to research data, the average annual birth rate in the Russian Federation is between 1.2 and 1.5 million of children. At the same time, about 60-150 thousands of children are born with a delay in prenatal growth, which is approximately 10-15% [18, p. 61-82].

Genetic factors determining the course of the pathology, its nature and the likelihood of complications are a very important component in the development of fetal growth retardation [19, C. 19-27].

New genetic markers, especially prenatal ones, have been identified and will significantly increase the level of diagnostics of the pathology in the future.

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EFFECT OF A WEAKENED MAGNETIC FIELD ON PLASMIC COMPONENT OF HEMOSTASIS SYSTEM AND HORMONAL PARAMETERS OF HEALTHY SUBJECT IN «ARFA-20» EXPERIMENT

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

The experiment «ARFA-20» simulated the effect of the Earth’s 500-fold weakened magnetic field on a healthy human organism. Eight healthy men aged from 26 to 44 participated in the research. The test subjects were in the «ARFA» experimental structure for 4 hours (background exposure), then for 24 hours in a regular magnetic field (control exposure) and another 24 hours in a 500-fold weakened magnetic field (experimental exposure). The interval between sessions was from 7 up to 14 days. In the citrated plasma in the subjects blood 7 days before the beginning of the experiment, as well as after the control and experimental exposure, determined the following indicators of plasma hemostasis: partial thromboplastin time, clotting time, thrombin clotting time, fibrinogen and D-dimer concentrations. Cortisol and free testosterone concentrations were also measured. Partial thromboplastin shortage relative to the background was observed both after the control and the experimental exposure. No significant differences were found between the control and the experimental sessions for this parameter. The other measured parameters did not differ significantly from the background values. The results of the study show the development of psychophysiological stress caused by prolonged immobilization over the course of the experiment, as the stress reaction causes an increase in the potential activity of the internal mechanism of coagulation cascade.

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ON THE HISTORY OF RESEARCH ACTIVITIES OF THE KUBAN STATE MEDICAL UNIVERSITY BASED ON THE 13th ISSUE OF SCIENTIFIC STUDIES DATED 1941

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The article carries out an analysis of the research activities of the Kuban Medical Institute in the pre-war period, based on the study of the 13th issue of research studies (Nauchnye “Trudy”) published in 1941, which demonstrates the general concept of the approach to the scientific work of the university and its diversity while also presenting the structure and features of the presentation of scientific research characteristic of the first half of the 20th century. The range of scientific trajectories reflects regional problems (elimination of trachoma, malaria), touches on fundamental and practical aspects, including those presenting interest on the eve of the war (use of streptocide novocaine blockades, treatment of pneumonia), that is, demonstrates interest in topical medical problems of that time. Some of them have something in common with modernity, for example, the problem of influenza and its differential diagnosis, suicide prevention, occupational diseases. “Trudy” was also a platform for the publication of dissertations. The article presents new and little-known facts of the biography of the director of the university A.N. Motnenko as a doctor and the head of the polar winter camp on Franz Josef Land. All this constitutes the novelty of this study, especially since in the present domestic and regional scientific literature, the issues of research activities of medical universities of this period are not sufficiently explored.

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CLINICAL CASE OF ALPHA-I ANTITRYPSIN DEFICIENCY OF 4-MONTH CHILD

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

The article demonstrates the clinical case of Alpha-I antitrypsin deficiency of a 4-month child. Child E was born in the maternity hospital №1 in Yakutsk. The mother was observed at a medical genetic consultation due to a habitual miscarriage. In the 1st half – mild toxicosis up to 13-14 weeks, risk of miscarriage from 10 weeks. The mother took Utrogectan. At 15-16 weeks, the mother contracted SARS-CoV-19. The infection was confirmed by a positive PCR (polymerase chain reaction). She was an outpatient, received Grippferon, pharynx rinsing with herbal decoctions. From the 17th week of pregnancy, a low level of hemoglobin (90 g/l) was detected, and Phenyls were prescribed. The mother was also diagnosed with ureaplasmosis and mycoplasmal infection by immunofluorescence. The mother had no unhealthy habits. The birth happened on 27’th week. Body weigh at birth – 1040 gr. Body height – 34 cm. Head circumference – 27 cm., chest circumference – 22 cm. Apgar’s score – 1/3/5. From 17.02.2021 at the age of 1 month 19 days, there was an acholic stool, according to a biochemical blood test performed on 18.02.2021, an increase in the level of alanine transaminase (180.2), a fraction of direct and indirect bilifulvin (215.66 and 24.3), alkaline phosphatase 1223 u/l. The attending physician of the child made a decision, due to the increase of the level of direct bilifulvin, the presence of a high level of alkaline phosphatase, the rapid growth of alkaline phosphatase, poor uptake of enteral nutrition, poor weight gain, prolonged jaundice, to cross out hereditary metabolic diseases. The diagnosis was confirmed with tests, karyotyping and phenotyping in RB№ 1 NMC. At this period, the child receives the full amount of necessary symptomatic treatment.

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ENDOTHELIAL AND DIASTOLIC DYSFUNCTION AMONG WOMEN OF PERIMENOPAUSAL AGE

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

Cardiovascular diseases progress among women in menopause, largely due to the progression of endothelial and diastolic dysfunction (ED and DD) during this period. Purpose of the study: to establish a correlation between DD and ED among women of perimenopausal age. Materials and methods: 80 women aged 45-55 years were included in the research. Patient intake and anthropometric data of all of the participants was collected. The endothelium function in the form of endothelium-dependent vasodilation (EDV) was assessed on the right brachial artery using the method of D.S. Celermajer и соавт. (1992). Echocardiography (EchoCG) with measurements of morphological and functional heart parameters was conducted. Results. The average age of the participants is 50 (47; 53) years. There were 50% of participants In natural menopause. ED was registered in 55% of women. 1st type of DD was registered in 46.3% women, 2nd – in 6.3%. Diastolic disorders were more common in women with ED than in women with normal vascular endothelium function. The V-Kramer coefficient between the indication of ED and DD was 0.30, p= 0.026. The V-Kramer coefficient between ED and obesity was 0.39, p <0.05; between ED and menopause 0.40, p<0.001. In overweight and obese women, DD was much more common than in women with normal body weight. A significant negative correlation between EDAT and BMI, the index of the maximum volume of the left atrial, and the peak rate of tricuspid regurgitation has been established. Conclusions. 1. ED and DD have a significant positive correlation among women of perimenopausal age. ED and DD are progressing in parallel and lead to global remodeling of CVS in women. 2. Overweight and obesity contribute significantly to increase of myocardial and vascular rigidity.

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EXAMINATION OF CLINICAL PATHOGENIC ASPECTS OF PSORIASIS WITH POSSIBILITY OF TREATMENT OF REVEALED DISORDERS

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

70 patients suffering from vulgar psoriasis at the stage of skin symptoms progression were examined. Two comparable groups of patients have been formed: I-st group (n=35) – was treated in accordance with clinical recommendations (standard therapy, 2015), II-2nd (n=35) – was treated with supplementary prescription of Cytoflavin (dosage regimen: 2 pills 2 times a day before meals for 25 days). The activity of autotoxemia and LOP processes was initially high, and correlation between indicators reflecting these homeostasis processes was confirmed. Cytoflavin therapy lead to the reduction of LOP and endotoxicosis processes, the breaking of correlation between clinical and cytokine profiles, the reduction of pathological symptoms, which improved patients’ quality of life.

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INSOMNIA CAUSED BY THE COVID-19 PANDEMIC AS A MEDICAL SOCIAL PROBLEM

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

March 11’th 2020 The World Health Organization (WHO) officially declared coronavirus infection of 2019 (COVID-19, SARS-CoV-2) a pandemic. The effects of COVID-19 consequences are of scientific interest due to its high incidence and the wide spread of various complaints among the patients, combined under the modern term of «post-covid syndrome». One of the most frequent symptoms of this syndrome is sleep disorder, manifested in the form of insomnia. This review article analyzes data on the COVID-19 pandemic impact on mental health of the affected population and medical personnel, in particular, on the incidence of insomnia. The aim of this article, according to the latest sources of literature, to identify the correlation between insomnia and COVID-19 pandemic.

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MANAGEMENT OF MEDICAL EQUIPMENT IN DEVELOPMENT OF ELECTRONIC JOURNAL OF ITS MAINTENANCE

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

The article studies the problem of processes of management research of medical equipment while developing the electronic journal of its maintenance. The development of data representation structural scheme in the automated system «Log of maintenance» has been presented. The developed electronic maintenance journal of medical institution allows storing information about the failures of medical equipment for an unlimited period of time, and to respond adequately to the occurrence of glitches. The cost of the automated system has been research, and it has been shown that the malfunctions of medical equipment lead to its downtime, as a result of which a prevention and treatment facility suffers various losses.

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DIETARY PROBLEMS IN PEOPLE LIVING IN IN RURAL AREAS

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

The dietary situation in recent years continues to be among the priority factors affecting the health of the population. The object of the study was the rural population of Astrakhan Oblast, which is of working age (188 women and 172 men). The actual individual diet was studied using a questionnaire. The analysis of the actual nutrition of the population identifies a decrease in the consumption of basic products relative to the recommended norms. The analysis also identifies a deficit of consumption of the main food groups in comparison with physiological norms: meat and meat products, fish, milk and dairy products, vegetables, fruits. The study concludes that the population is characterized by a carbohydrate model of nutrition and a lack of animal proteins.

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MODERN LIFE QUALITY PROBLEMS OF RURAL POPULATION

Posted in 2022, Issue № 5 (119) May 2022, MEDICINE | 0 comments

In today’s living conditions, problems of medical-demographic and social nature are more evident in rural areas. As the basic research method, a questionnaire was conducted. Negative factors of relative and absolute risk affecting health and quality of life have been determined: undereducation, low income, low level of home improvement, excessive smoking, hypodynamia. The level of medical activity and that of satisfaction with the medical services provided to the rural population have been determined. There is also a need to improve measures of increasing preventive activity and spreading of healthy lifestyle principles.

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EPIDEMIOLOGICAL ASPECTS OF INFLUENZA IN ASTRAKHAN REGION IN 2016 – 2020

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The aim of the study. To study the epidemiological situation of influenza in the Astrakhan region in 2016 – 2020.

Materials and methods. During the given period, 12,025,553 cases of infectious and parasitic diseases were registered in the Astrakhan region, of which 74.6 per cent (n=897,074) were children under 17 years of age.

The results of the study. During the analyzed period, 5,733 cases of human influenza were registered in the Astrakhan region. Most of the patients were children under 17 years of age – 63.9% (n=3663).

The majority of cases were in urban areas – 92.3 per cent (n=5,290), of which 64.4 per cent (n=3,405) and 93.0 per cent – of all children were diagnosed with influenza. The proportion of persons living in rural Astrakhan region was 7.7% (n=443), of whom 58.2% (n=258) and 7.0% – of all children were diagnosed with «Influenza».

The influenza is considered to be seasonal, it being more common in the cold season. In the observations, cases of influenza were registered in the autumn-spring period from October to April.

Conclusions: Having carried out a retrospective analysis of the course of influenza, it may be noted that this disease has been increasing in the number of cases in recent years (2018 – 2020). The disease was registered in all age groups, often in child population (63.9 per cent). The highest number of cases of influenza was registered during the winter period from January to March.

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PROSPECTS FOR THE USE OF LEAN TECHNOLOGY TOOLS IN THE OCCUPATIONAL PATHOLOGY SERVICE

Posted in 2022, Issue № 04 (118) April 2022, MEDICINE | 0 comments

In today’s Russian healthcare, the problem of saving labor and financial resources is quite urgent. One of the promising management principles is lean manufacturing, which is aimed at reducing costs while improving the efficiency and quality of medical services. There are works testifying to the positive results of the use of lean technologies in the healthcare systems of different countries. In recent years, a new model of a medical organization providing primary health care using lean manufacturing methods has also been implemented in Russia. The purpose of the study was to assess the possibility of using the principles of lean manufacturing in the development of occupational pathology services (based on the Republic of Tatarstan).Research material: data from the Department of Rospotrebnadzor of the Republic of Tatarstan, the register of occupational Diseases of the Republican Center of Occupational Pathology, primary documentation of patients with occupational pathology. Research methods: statistical, lean technology method (value stream mapping).

Results. The article analyzes the main aspects of the interaction between patient, doctors, and the nursing staff, and determines the algorithm of actions of the medical staff / patient in the flow of actions for the examination of the connection of the disease with the profession. The authors identifies bottlenecks and losses in the workflow during the provision of occupational pathology care as well as determines ways of solving the implementation of the necessary actions for the transition to the target state. Conclusion: the provision of primary health care in occupational pathology is accompanied by certain losses. The use of lean technology methods will optimize the logistics of patient movement during the examination of the connection of the disease with the profession and the examination of professional suitability. The analysis of the flow problem made it possible to identify solutions and develop a step-by-step plan for implementing the necessary actions to move to the target state.

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ON THE FEATURES OF HEART RATE IN 16-17-YEAR-OLD FOOTBALL PLAYERS

Posted in 2022, Issue № 04 (118) April 2022, MEDICINE | 0 comments

The study was conducted over two academic years (the beginning and the end of each academic year) with the same contingent of students aged 16-17 years engaged and not engaged in football. The experiment was conducted in a youth sports school. The average sports experience by the end of the study was 7 years. The control group was engaged in physical culture two hours a week. The aim of the study was to examine the heart rate variability in football players aged 16-17 and their peers who do not play sports. The study determined the features of the adaptation of the heart rate of young football players and their peers who were not involved in football.

By the end of the first year of the study, the sympathetic type of regulation increases in football players (41.67%), which indicates the tension of adaptation mechanisms. The same pattern was found in young men who were not involved in sports by the end of the second year of the study. It was found that at the end of the second year of the study, according to the degree of activation of the parasympathetic department of the autonomic nervous system, two groups were identified: 50% registered normal values, while the second half showed the tension of the heart rhythm mechanisms and unsatisfactory adaptation. The results obtained expand the understanding of the age-related features of the functioning of the cardiovascular system during physical exertion of different capacities in athletes.

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EPIDEMIOLOGICAL ASPECTS OF HUMAN TOXOCAROSIS IN ASTRAKHAN OBLAST

Posted in 2022, Issue № 04 (118) April 2022, MEDICINE | 0 comments

Toxocarosis is of great interest to doctors, since in this disease the pathological process affects different systems of the body. There is a wide variety of clinical symptoms, as well as diagnostic methods and treatment tactics for this disease.

In the period from 2016 to 2020, Astrakhan Oblast reported 36 episodes of human toxocariasis. During the period under study, the share of toxocarosis accounted for 0.4% of episodes and 0.2% of the total number of all helminthiases that were registered in Astrakhan Oblast in the period from 2016 to 2020.

Toxocarosis can be observed in both children and adults. The share of the age population accounted for 83.6%, including the working population – 66.8%, the retired citizens – 12.3%, and the unemployed – 3.4%.

The share of children in the incidence of toxocarosis accounted for 18.3%, among whom 12.3% attended secondary schools, 3.2% attended secondary schools, and another child was at home with its parents – 3%.

The main clinical symptoms of persons who applied to a medical institution were the following: dry cough – 22.8%, asthenia – 18.2%, pain in the epigastrium, as well as subfebrile body temperature – 12.4% each, vasomotor rhinitis and myalgia with arthralgia – 5.7%.

Also, 2.7% of patients complained of decreased appetite, dermatitis, shortness of breath, and weight loss.

Epidemiological history demonstrates that the most frequent factors of the development of the disease were the following: non–compliance with the rules of personal hygiene – 93.8%, eating unwashed vegetables and fruits – 87.9%, close contact with pets – 63.5%, nail biting (onychophagia) – 21.3%, consumption of soil and various types of soil (chalk, clay) and hand licking – 8.7% each.

The main choice of the method of laboratory diagnosis of toxocarosis was the method of enzyme immunoassay, which was used to detect antibodies to toxocar antigens with class J immunoglobulins (CJSC “Vektor–Best”, Rostov).

Conclusions:the problem of human toxocarosis remains relevant today, this is proved by new cases of this disease. The age category of citizens varied: the disease affects both children and adults. The most frequent risk factors for the development of the disease are close contact with animals and non-compliance with the basics of personal hygiene. The evidence of the presence of parasitic infection in patients is the detection of antibody titer 1:800 and higher in sick citizens, and in addition the presence of clinical symptoms of the disease.

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