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MEDICINE

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ПИ № ФС 77 - 51217, 18+

STUDY OF BACILLUS ATROPHAEUS INACTIVATION WITH CLEAN AND MODIFIED CARBON DIOXIDE

Posted in 2018, Issue №12(78) December 2018, MEDICINE | 0 comments

The authors consider the possibility of the use of supercritical fluids as sterilizing agents for medical devices. They conducted studies on the inactivation of Bacillus atrophaeus with pure and modified supercritical carbon dioxide. It has been found that under certain thermodynamic parameters, modified CO2 is an effective sterilizing agent against Bacillus atrophaeus spores. The duration of achieving complete inactivation is also determined.

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CORRECTION OF SYSTEMIC INFLAMMATION WITH POSITIONAL COMPRESSION SYNDROME

Posted in 2018, Issue №10(76) October 2018, MEDICINE | 0 comments

The results of the treatment of 11 patients with acute renal damage with positional compression syndrome are presented in the paper. Combined plasma filtration and adsorption (SPFA) was used in complex therapy. The analysis of the effectiveness of the SPFA was also carried out. The dynamics of proinflammatory and anti-inflammatory cytokines was studied. A significant decrease in the level of TNF-a, IL-1β, IL-6, IL-10 was revealed. After SPFA, there is a significant decrease in proinflammatory cytokines of TNF-a by 50.4%, interleukin IL-1β by 52.6%, IL-6 by 37.4%, and a decrease in the level of anti-inflammatory cytokine IL-10 by 43, 9%.

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MAIN FEATUES OF CLINICAL COURSE OF PERIPHERAL ATHEROSCLEROSIS UNDER CONDITIONS OF TERRITORY CONTAMINATED BY TECHNOGENIC RADIONUCLIDES

Posted in 2018, Issue №10(76) October 2018, MEDICINE | 0 comments

The main features of clinical course of peripheral atherosclerosis in males who permanently live in the mountains near uranium tailings were studied. It is established that these patients fall ill earlier in comparison with the control group, which indirectly indicates the dominating impact of environmental factors on the pathological process. The vascular lesion located in the popliteal pedidial segment was more characteristic for this category of people. In comparison with the control group living in an ecologically “clean” zone, patients of the main group had the femoropopliteal shunt procedures more often which indirectly indicates the involvement of the distal vascular bed into the pathological process.

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СРАВНИТЕЛЬНЫЙ АНАЛИЗ ЛОКАЛЬНОЙ И СИСТЕМНОЙ КОРТИКОСТЕРОИДНОЙ ТЕРАПИИ У ПОСЛЕОПЕРАЦИОННЫХ ПАЦИЕНТОВ С АЛЛЕРГИЧЕСКИМ РИНИТОМ С НАСАЛЬНЫМИ ПОЛИПАМИ

Posted in 2018, Issue №10(76) October 2018, MEDICINE | 0 comments

Allergic Rhinitis with Nasal Polyps is a clinical entity of great importance that is yet to be fully understood. It is the chronic inflammation of the nose and paranasal sinuses and is characterized with the formation and recurrent growth of polyps that are mostly infiltrated with neutrophils and eosinophils. This pathology is considered chronic and slow growing in nature. It considerably hinders nasal breathing and may bring about various complications. A diagnosis can be made by the presence of both subjective and objective evidence of chronic sinonasal inflammation. Allergic rhinitis with nasal polyps has a 1-5% prevalence in the world population, comprising 5-20% of all ENT diseases. Despite the fact that in the last 20-30 years this disease has been thoroughly investigated by many with abundant literature readily available, nonetheless, the exact mechanism of pathogenesis is still unclear. We currently classify 3 different types of pathogenic mechanisms including infectious-allergic, autoimmune and neurovascular. The aim of this study is to collect data and present a comparative analysis on conservative treatment methods of allergic rhinitis with nasal polyps at the post-operative period based on the above mentioned etiopathogenetic factors.

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ANALYSIS OF PROTHROMBOTIC PLEOMORPHISM OF GENES OF COAGULATING HEMIC SYSTEM IN CHILDREN WHO UNDERWENT THROMBOSIS

Posted in 2018, Issue №10(76) October 2018, MEDICINE | 0 comments

Thrombophilia is a body state characterized by increased formation of clots and uncontrolled spread of blood clots beyond the damage. Thrombophilia can be asymptomatic for a long time or manifest itself as thrombosis. The predisposition to thrombosis can be genetically conditioned, but this predisposition does not necessarily result in thrombosis. The article contains a retrospective analysis of 34 clinical charts of children inpatients and adolescents aged 0 to 17 years with diagnosed venous thrombosis. The most common thrombosis developed in newborns and children of the first year of life (26.5%), and in children older than ten years old (50%). 47% of patients had the history of the hereditary burden of thrombophilia. 24 children were examined for genes pleomorphism of hemic system coagulation. Genetic predisposition to thrombosis was detected in 91.5% of cases. Revealed changes contain heterozygous mutation in MTGFR 677T gene; 222T was diagnosed in 33.3% of patients, homozygous mutation in 25% of children, while homozygous mutation in MTGFR gene was often combined with other mutations – pleomorphism in the fibrinogen receptor gene, plasminogen activator inhibitor, heterozygous mutation in V, VII, XIII factors, hyper-aggregation of platelets. Leiden mutation was found in 12.5% of the patients, deficiency of C and S proteins and plasminogen in 4.2% of children, moderate deficiency of protein C in 4.2%, pleomorphism in the platelet fibrinogen receptor gene (IGB3)-3 in 12 , 5% of those surveyed. No changes were detected only in 8.3% (2) of children. The most common mutation was observed in MTGFR gene in 23.5% of patients.

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FACTORS AFFECTING QUALITY OF LIFE AND PSYCHO-SOCIAL ADAPTATION OF PATIENTS WITH PANIC ATT

Posted in 2018, Issue №10(76) October 2018, MEDICINE | 0 comments

The article studies psychometric characteristics and indicators of quality of life in men and women with panic attacks (PA). Emotional liability of women with PA is much more pronounced than that of men. The main factor in the deterioration of the quality of life of patients with PA is a decrease in social activity and self-esteem of mental health, which affect each other. To a lesser extent, quality of life is affected by restrictions in daily activities due to deterioration in physical health. All these factors lead to psycho-social maladjustment of patients. Patients with PA first of all require the increase of social activity, which is the task of not only the attending physician but also of social institutions.

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CORRECTION OF PROLONGED HEMOFILTRATION OF LIPID PEROXIDATION IN ABDOMINAL SEPSIS

Posted in 2018, Issue №9(75) September 2018, MEDICINE | 0 comments

Continuous hemofiltration was used in combination therapy of 27 patients with abdominal sepsis, with developing multichannel insufficiency or septic shock. Indicators of oxidative stress were studied. The enhancement of lipid peroxidation and the decrease in the content of α-tocopherol are established. Continuous hemofiltration improved the performance of antioxidant protection. The calculated coefficient of oxidative “K” stress in the serum and erythrocytes, normally approaching unity, was initially increased by 2.8 and 2.59 times, respectively. This index improved significantly after prolonged hemofiltration but remained elevated 1.28 and 1.72 times in plasma and erythrocytes.

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DETERMINATION OF LOCAL SANITATION ACTIVITIES ALGORITHM IN CHILDREN WITH THE EMPIEMA OF PLEUR

Posted in 2018, Issue №9(75) September 2018, MEDICINE | 0 comments

In order to improve the results of treatment of children with pleural empyema and to evaluate the effectiveness of various methods of local sanatorium interventions, the results of treatment in this pathology in children who were treated with drainage of the pleural cavity and thoracoscopic sanitation were analyzed. Fifty six children with destructive pneumonia complicated by empyema of the pleura were on examination and treatment from 2014 to 2018 in the Department of Pediatric Surgery in Vladimirsky Moscow Regional Research Clinical Institute. All children were treated with draining of the pleural cavity with an aspiration system connected. Five patients underwent videotoracoscopic sanation of the pleural cavity. Adequate and timely drainage of the pleural cavity in combination with enzyme and antibacterial therapy has proved to be an effective method of treating pleural empyema. In the absence of pulmonary dilatation after drainage, formation of confined purulent cavities for 10-12 days, rational use of thoracoscopic sanation of the pleural cavity is rational.

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USE OF METHYLENE BLUE IN INTRAOPERATIVE SEARCH OF PARATHYROID GLANDS

Posted in 2018, Issue №9(75) September 2018, MEDICINE | 0 comments

The original technique for intraoperative identification of parathyroid glands with the use of aniline dyes was proposed and tested in this work. This technique implies the introduction of a 0.1% aqueous solution of methylene blue into the lower thyroid artery. The procedure is simple and does not require additional costs for special equipment and other expensive dyes. This method can be taken for everyday use in the work of endocrinology surgeons. Thus, a simple and inexpensive study can significantly reduce the time of surgery, keep the parathyroid glands and the recurrent laryngeal nerve under visual control when resecting the thyroid gland.

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USE OF VISUAL CONTENT TO BOOST MOTIVATION OF CHILDREN TO GET ORTHODONTIC TREATMENT

Posted in 2018, Issue №9(75) September 2018, MEDICINE | 0 comments

The article presents the results of a study aimed at increasing motivation of children to get orthodontic treatment by means of showing thematic cartoons. Using the elements of visual pedagogics (visual content) allowed raising interest and the level of the patients’ motivation for further orthodontic treatment (100% of children in the experimental group). An increase in the level of hygiene was noted in 67.6% compared with the baseline, and the level of dental compliance rose by 30.6%. This, in turn, has improved the children’s self-esteem, the level of their sociability and, in general, the quality of life.

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LIFE QUALITY EVALUATION OF PATIENTS WITH СHD DIAGNOSIS AND CHF OF 2A STAGE, IN AMBULATORY FILES IN POLYCLINICS OF KIROV AND SOVIET REGION OF UFA

Posted in 2018, Issue №8(74) August 2018, MEDICINE | 0 comments

483 outpatient cards of patients with IHD diagnosis and CHF of 2a stage were analyzed to study the dynamics of treatment and the severity of residual unfavorable clinical symptoms in these patients. It was found out that the leading clinical symptom is shortness of breath, one-third of patients have orthopnea, half of them have tachycardia and swelling of the lower limbs. The sinus rhythm of the ECG was preserved in 66% of patients, atrial fibrillation was detected in 26%, and 7% of patients had other abnormalities of rhythm and conduction. 18.6% of the patients studied have COPD, 12.2% have diabetes. After surgical treatment, the physical health is 40.8 ± 6.3, and the psychological one is 52.8 ± 8.9 (based on the results of the SF-36 questionnaire).

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ULTRASONIC DIAGNOSIS OF THE POSTERIOR SEGMENT OF THE EYEBALL AFTER TAMPONADE OF A VITREAL CAVITY WITH SILICONE OIL IN OPAQUE OPTICAL MEDIA

Posted in 2018, Issue №8(74) August 2018, MEDICINE | 0 comments

The article is devoted to the problem of visualization of incomplete attachment of retina after vitrectomy with vitreous cavity tamponade with silicone oil in opaque optical media. Twenty-three patients with a silicone tamponade were examined with the use of ultrasonography in b-mode on two systems with US-sensors of different frequencies on different instruments (Hi-scan 12 MHz and Aviso 20 MHz). In 16 patients, no changes were observed in the anterior part of the eye and in ophthalmoscopy, three of which showed a relapse or incomplete attachment of retina, which was also confirmed by eye fundus and optical coherence tomography (OCT). Cataract of varying intensity, making it difficult to examine the fundus, was found in 7 patients, two of them were diagnosed with a relapse of retinal detachment with the help of ultrasonography. The results obtained proved the possibility of differentiating the changes in the posterior segment of the eyeball filled with silicone oil using a 12 MHz ultrasonic sensor.

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HARMONIZATION OF INSTANT DIAGNOSIS METHODS OF ERYTHROCYTE SEDIMENTATION RATE IN MEDICAL LABORATORIES PRACTICE

Posted in 2018, Issue №7(73) July 2018, MEDICINE | 0 comments

The comparability of the erythrocyte sedimentation rate (ESR) was estimated with the use of the traditional analytical quality characteristics. The results were obtained by the Westergren reference method on the DESAGA SEDIPLUS S2000 analyzer (Desaga Sarstedt-Gruppe, Germany) and the telemetric method of measuring the erythrocyte aggregation kinetics with the use of TEST 1 instrument (AliFax, Italy). The inter-instrumental reproducibility is 2.7% on the average with a shift of 8.2%. The division of the measurement range into significant intervals from the viewpoint of clinical interpretation showed no statistically significant differences when measuring ESR above 15 mm/hour (p> 0.05). Harmonization of instant diagnosis methods of erythrocyte sedimentation rate by studying the characteristics of the analytical quality and comparing the results of the patients’ samples with the reference method made it possible to obtain an idea of the acceptable comparability of the studied parameters and the features of the ESR interpretation in different ranges of the studied parameter.

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QUANTITATIVE ANALYSIS OF SYNAPTIC CONTACTS AND RECEPTORS OF CEREBRAL HEMISPHERES OF HUMAN EMBRYONS: NORMAL AND IN CONDITIONS OF PRENATAL MATHER ALCOHOLATION

Posted in 2018, Issue №7(73) July 2018, MEDICINE | 0 comments

The parameters of ultrastructural and receptor manifestations of the effect of maternal prenatal intoxication on synaptogenesis and the properties of benzodiazepine receptors are established based on the human brain material, 6-15 weeks of gestation. The forms of intercellular connections between neuroblasts in the intermediate layer of the cerebral cortex were identified depending on the duration of gestation. Structural delays in the development of synaptic contacts of the avesicular and vesicular types were established. The reduction of density and affinity of receptors of synaptosomal membranes was established on the material of human embryonic brain, which develops under the conditions of alcoholic intoxication of the mother organism.

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ESTIMATION OF EMOTIONAL STATE AND ATTENTION OF STUDENTS USING DIFFERENT TYPES OF PHYSICAL LOADS

Posted in 2018, Issue №7(73) July 2018, MEDICINE | 0 comments

The features of the emotional state and the attention of students using different types of exercise were considered. It was established that higher levels of health indicators, activity, moods are observed among students engaged in powerlifting. At the same time, high values of attention stability were revealed among students engaged in physical activities only in physical training classes at the university and fitness. The evaluation of the progress of students engaged in various types of physical activity was made. It was established that students involved in powerlifting and fitness have higher rates of academic performance compared to students who were not additionally engaged in sports.

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ESTIMATION METHODS OF EARLY EMBRYOGENESIS IN CLINICAL PRACTICE

Posted in 2018, Issue №7(73) July 2018, MEDICINE | 0 comments

The paper presents the retrospective analysis of estimation methods for assessing early embryogenesis in clinical practice using additional reproductive technologies, such as preimplantation genetic diagnosis of trophectoderm, noninvasive prenatal testing using free fetal DNA in the blood, a genetic study of abortive material in women of reproductive age. The effect of the mother’s age factor on the genetic abnormalities of the fetus is assessed. The most frequently occurring chromosomal anomalies of embryos in the control and experimental groups are indicated.

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POSSIBILITIES OF SURGICAL TREATMENT OF METASTATIC LESIONS OF SPINE

Posted in 2018, Issue №6(72) June 2018, MEDICINE | 0 comments

The article presents various options for surgical treatment of metastatic spine lesions. The material presented is the study of a number of domestic and foreign scientific articles, for the period of 2000 to 2017. Operative treatment of metastatic spinal lesions in most cases is palliative, aimed at restoring the neurological deficit, reducing the pain syndrome, implementing local control over tumor growth, restoring stability in the affected segment.

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MULTIOCULAR SCLEROSIS. COMPARISON OF INCIDENCE RATE IN OMUTNINSKIY (NORTHERN) AND URZHUMSKIY (SOUTHERN) DISTRICTS OF THE KIROV REGION

Posted in 2018, Issue №6(72) June 2018, MEDICINE | 0 comments

The main theories of the etiology and pathogenesis of multiocular sclerosis are presented. The main symptoms are considered, the types of the course of the disease are given. The level of occurrence of multiple sclerosis in men and women was compared in the study. Attention is paid to the age characteristic of the debut of multiocular sclerosis. The main objective of the paper is to assess the impact of the geographical factor on the risk of multiocular sclerosis by comparing the incidence of the disease in Omutninskiy District (Northern) and Urzhumskiy District (Southern) of the Kirov Region.

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MODERN VIEWS ON THE PATHOGENETIC THERAPY OF ERYSIPELAS

Posted in 2018, Issue №6(72) June 2018, MEDICINE | 0 comments

Present-day data on the incidence of erysipelas and factors predisposing to its development are presented in the paper. Current directions for studying the pathogenesis of the disease are presented, as well as an overview of the main methods of pathogenetic therapy of erysipelas and prevention of its relapse. The relevance of the use of drugs that have an immunomodulating effect on the factors of innate immunity is shown. The necessity of using pathogenetic therapy, which simulates the activity of macrophagal phagocytosis, in the complex therapy of erysipelas of the lower extremities is substantiated.

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PHARMACOKINETICS OF ANALOGS OF INSULIN OF LONG-TERM ACTION IN INSULIN-DEPENDENT DIABETES

Posted in 2018, Issue №5(71) May 2018, MEDICINE | 0 comments

According to the review of the literature, the pharmacokinetic features of modern insulin analogs of long-term and super-long-acting effects that affect the efficiency and safety of insulin therapy in insulin-dependent diabetes are presented. The existing problems associated with the onset of insulin therapy, as well as the ways to solve them are considered. All the peculiarities and drawbacks of the existing analogs push the modern pharmaceutical industry to modify already well-researched, effective and safe analogs, to create equivalent biosimilars, and to find ways to stabilize the pharmacodynamic properties of human insulin through more predictable pharmacokinetics.

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