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MEDICINE

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ЭЛ № ФС 77 - 80772, 16+

ON THE PSYCHOEMOTIONAL STATE AMONG FOREIGN FIRST-YEAR STUDENTS

Posted in 2021, Issue № 12 (114) December 2021, MEDICINE | 0 comments

One of the most important aspects in the education of foreign citizens is the processes of adaptation of students to new conditions in a new country. The purpose of the study is to assess the psychoemotional background of foreign first-year students that study using an intermediary language (English). Materials and methods. To assess the psychoemotional state of students, the study conducted a survey of 149 foreign students, A.T. Beck’s and U. Tsung’s standard depression scales were used; for the assessment of reactive personality anxiety, the survey used the Spielberger-Hanin test. Results. Most of the respondents examined corresponded to a moderate level of reactive (100 or 67.1%) and personal anxiety (88 or 59.1%). Close to a third of foreign students showed a high level of personal and reactive anxiety (32.2% and 29.5%, respectively). The majority of respondents corresponded to the norm level on the Tsung scale (136 people or 91.3%), mild depression was detected in 12 respondents (8.1%), subdepression was detected in 1 male student (0.6%). The overwhelming majority of international students corresponded to the normal level of depression on the Beck scale (96 people or 64.4%), mild depression was detected in 32 respondents (21.5%), moderate and severe depression was detected in 8 people. 5 students corresponded to the level of severe depression. There is a direct correlation between the level of personal anxiety and the level of depression (coefficient r=0.39 at the level of p<0.001 according to the Tsung scale, r=0.43 at the level of p<0.001 according to the Beck scale) Conclusions. The data obtained scientifically substantiate the need for adaptation measures for foreign students with monitoring of the psychological state.

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EARLY DIAGNOSIS AND PREVENTION OF CARDIOVASCULAR DISEASES AMONG YOUNG PEOPLE

Posted in 2021, Issue № 12 (114) December 2021, MEDICINE | 0 comments

Cardiovascular diseases (CVD) continue to occupy relevant positions within the framework of modern healthcare problems. This pathology is characterized by a high prevalence, frequency of complications and a high level of disability and mortality among the able-bodied population. An important fact that raises concern in the medical community is not only the continuing trend towards an increase in morbidity but also the so-called spread among the population who were previously less susceptible to the development of this pathology. This circumstance dictates the need to take into account the risk factors of CVD, which are characteristic of young age. As part of solving this problem, first of all, it is necessary to analyze the main risk factors affecting the development of CVD and develop scientifically-based preventive measures for young people with an underlying risk to develop CVD, taking into account the prevalence of risk factors in modern socio-economic conditions. To achieve this goal, it is necessary to activate the system of disease prevention, both at the state level and at the level of the practical health service.

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A RETROSPECTIVE EPIDEMIOLOGICAL ANALYSIS OF THE INCIDENCE OF ACUTE RESPIRATORY VIRAL INFECTIONS

Posted in 2021, Issue № 12 (114) December 2021, MEDICINE | 0 comments

In this article, the authors present material on a retrospective analysis of the incidence of acute respiratory viral infections in the village of Poltavskaya of the Krasnoarmeysky district of the Krasnodar Territory during the epidemiological season of influenza and SARS in the period from 2019 to 2020. The research was carried out in the State Medical Institution “Krasnoarmeyskaya Central District Hospital” from September 2019 to February 2020.

In the course of this period, 150 people were under the supervision of the authors who sought medical help from a district therapist with a preliminary diagnosis of acute respiratory viral infection. The authors analyzeв the outpatient admission cards of patients, among which males made up 55%, and females 45%. The age of the applicants ranged from 18 to 80 years. with adequately prescribed therapy and with the implementation of all prescribed recommendations, the temperature of patients lasted from three to five days from the start of treatment, with a rare case up to seven days. When seeking medical help, patients had the following complaints: fever, weakness, headache, cough, sleep disturbance, sore throat when swallowing, chest pain, nasal congestion, and hoarseness of voice.

In all cases, the final diagnosis was made, taking into account complaints, anamnesis, physical examination data, clinical laboratory blood analysis with leukocyte formula, and general urinalysis.

The duration of the disease and being on the sickness certificate most often ranged from 10 to 15 days. The following drugs were used in the treatment of ARVI: “Oseltamivir”, “Nomides”, “Influceil”, “Cycloferon”, “Kagocel” and “Ergoferon”.

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LABORATORY DIAGNOSTICS OF THE VARIANTS OF THE CLINICAL COURSE OF INFECTIVE ENDOCARDITIS

Posted in 2021, Issue № 12 (114) December 2021, MEDICINE | 0 comments

The aim of the study was a comparative assessment of clinical and laboratory parameters of patients with an uncomplicated course of infective endocarditis (IE), as well as with its thromboembolic complications (TEC). The study involved 138 patients (52±12 years old) with IE at the State Medical Institution “NII – KKB No. 1” (Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky); the patients were divided into subgroups according to the clinical form of IE and the presence/absence of athromboembolic complications; the study evaluated hematological, biochemical and coagulological parameters, as well as the presence of infectious pathogens, in their peripheral venous blood. The article identifies changes in laboratory parameters common to all patients with IE, reflecting the processes of inflammation and changes in the functioning of the affected organs, as well as some laboratory criteria for uncomplicated primary and secondary IE and markers of their thromboembolic complications. Also, the article substantiates the necessity of expanding the spectrum of laboratory diagnostics of IE by determining diagnostically significant cytokine markers and genetic polymorphism of their genes.

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PRIMARY DATA ON VACCINATION OF PREGNANT WOMEN AGAINST CORONAVIRUS INFECTION

Posted in 2021, Issue № 12 (114) December 2021, MEDICINE | 0 comments

The development of a vaccine against coronavirus infection as the only effective method of prevention has become a new aspect of this infection. The purpose of this study was to examine the safety of vaccines used for pregnant women and their children.

The article presents a literary review of world research on the effect of the coronavirus vaccine on pregnant women as well as describes the effectiveness and safety indicators of the registered vaccines. The article shows that the vaccine “Gam – Covid Vac”, approved in Russia for use among pregnant women, does not adversely affect the course of pregnancy and fetal development. The authors present the clinical observation of 48 pregnant women vaccinated against COVID-19 at different stages of pregnancy while also providing a description of the course of pregnancy before and after vaccination, the outcomes of childbirth in vaccinated pregnant women.

Conclusion: the authors present favorable results of vaccination against COVID-19 and note that none of the patients had adverse reactions and complications of pregnancy and childbirth after the introduction of the Gam – Covid Vac vaccine that required medical intervention.

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PREREQUISITES FOR THE CREATION OF SPECIALIZED PRODUCTS FOR LIVER DISEASES IN EXTREME CONDITIONS OF THE NORTH

Posted in 2021, Issue № 12 (114) December 2021, MEDICINE | 0 comments

Serological studies have revealed a high intensity of the epidemic process among the population of the Republic of Sakha (Yakutia). Among the population of the republic, there is a high proportion of seropositive persons for all viral hepatitis with the highest rates of hepatitis C in the group of conditionally healthy persons (23.2%), hepatitis B (20.2%), hepatitis E (21.2%). The easy digestibility of venison compared to other types of meat, the fast digestibility of fish proteins makes it possible to recommend them in the treatment of acute forms of hepatitis. Fermented milk products with natural food plants of Yakutia are characterized by a high content of protein substances, carbohydrates, macro-microelements, and biologically active compounds, which makes it possible to recommend them for acute and chronic forms of viral hepatitis.

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INFORMATION TECHNOLOGIES IN THE DIAGNOSIS OF HEARING LOSS IN CHILDREN REPUBLIC OF TYVA

Posted in 2021, Issue № 12 (114) December 2021, MEDICINE | 0 comments

The article presents the results of a study of the structure of otopathology in children of different age groups of the Republic of Tyva using originally developed software.

The determined features are of great importance not only for identifying the causes of their development but also for clarifying the pathogenetic mechanisms. This helps to identify pathogenetically justified, personalized ways of their correction, develop and carry out preventive measures, as well as give recommendations to doctors, thereby improving the professional activities of pediatricians, otorhinolaryngologists, and surdologists of the region, taking into account the difficult harsh climate of the region, as well as the inaccessibility of qualified medical care to residents of remote settlements.

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A HYGIENIC ASSESSMENT OF THE DAILY ROUTINE AND DIET OF MEDICAL UNIVERSITY STUDENTS

Posted in 2021, Issue № 12 (114) December 2021, MEDICINE | 0 comments

The measures of preventing the adverse effects of environmental factors on the health of children and adolescents in the Russian Federation are receiving increased attention. The creation of conditions for the preservation and strengthening of the health of the younger generation is carried out systematically in accordance with the “Desyatiletie detstva” (Decade of Childhood) program [1], [2], [3].

Educational organizations implement measures aimed at preserving and strengthening the health of students. However, the severity of the problem of morbidity of the child population associated with the influence of environmental factors persists despite the active socially-oriented policy of the state and the activities of educational institutions. [4]. In order to study the lifestyle of modern students, the authors carry out an analysis of the daily routine and diet.

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CORRELATION FEATURES OF HEART RATE VARIABILITY INDICATORS IN DIFFERENT VARIANTS OF COGNITIVE LOAD IN STUDENTS

Posted in 2021, Issue № 12 (114) December 2021, MEDICINE | 0 comments

In the general study groups, the correlations between HRV indicators (heart rate variability) determined in the article have a basic pattern with various variants of cognitive loads and are correlations of the first level, which reflect the presence of “rigid” HRV regulation circuits, the structure of which does not change under various physiological conditions. In gender groups, there is a redistribution of the dominant influence in the regulation of HRV of the departments of the autonomic nervous system. Therefore, the authors distinguish the “plastic” contours of HRV regulation. On the one hand, the presence of “plastic” regulation circuits is a mechanism of adaptation to various types of stress, and on the other hand, “plastic” circuits can be a “weak” link in the regulation mechanism when systems move to a new level of disequilibrium and an imbalance is formed between sympathetic and parasympathetic influences on cardiac activity. Evaluation of the organization features of such regulatory circuits allows for developing methods of early correction, diagnosis and prognosis of pathological conditions.

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AN ANALYSIS OF DIET OF PRIMARY SCHOOL STUDENTS

Posted in 2021, Issue № 12 (114) December 2021, MEDICINE | 0 comments

Proper nutrition ensures the normal growth and development of children, contributes to the prevention of diseases, prolongs people’s lives, improves working capacity, and creates conditions for their adequate adaptation to the environment. The purpose of this study is to clarify the nutritional characteristics of primary school children. The study involved 250 students of grades 1-4 living in Astrakhan Oblast. The research shares information on the nutrition regime of schoolchildren. The diet of school-age children is not optimal and does not ensure timely and sufficient nutrition. Therefore, it is necessary to make changes at the different levels of the content and methods of promoting a healthy lifestyle.

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AN ANALYSIS OF HEALTH IN TEACHERS OF GENERAL EDUCATION INSTITUTIONS

Posted in 2021, Issue № 12 (114) December 2021, MEDICINE | 0 comments

A secondary school teacher is a key figure in the educational process, the effectiveness of which depends not only on their professional literacy but also is determined by their physical and mental health. At the same time, teachers are included in the group of professional, social, and medical risk due to poorly studied factors of working conditions, lack of time, insufficient awareness of teachers of methods of preserving and strengthening their own health, as well as low quality of medical care. Modern realities allow for forming the problem of researching ways to preserve the health of teachers as a basic component of their general and professional culture. The purpose of the study is to analyze the health status of teachers in Astrakhan Oblast and identify the main factors that negatively affect their health. The study was conducted on the basis of questionnaire data and a survey of secondary school teachers. Based on the results obtained, the study concludes that it is necessary to develop and implement social and medical prevention programs aimed at forming a healthy lifestyle in the pedagogical environment.

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TODAY’S PROBLEMS OF IMPROVING THE HEALTH OF CHILDREN AND ADOLESCENTS IN CHILDREN’S CAMPS

Posted in 2021, Issue № 12 (114) December 2021, MEDICINE | 0 comments

The current article presents an analysis of modern scientific literature on the problem of improving the health of children and adolescents in children’s camps. The relevance of this study is determined by the decrease in the physical capabilities of the younger generation in recent years, as well as an increase in the frequency of acute and chronic diseases, which necessitates the formation and improvement of the effectiveness of health measures.

The factual and statistical data gathered in recent years that are presented in the annual state reports “On the situation of children in the Russian Federation” [1], indicate a crisis in the socio-economic situation of children in our society. More and more minors are in need of support from the state, in particular, in creating a favorable environment for health promotion, formation and maintenance of social ties with other people. This indicates that the rational organization of recreation and health improvement of children in modern conditions is an effective measure to preserve and strengthen the health of the younger generation.

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THE NEW HETEROCYCLIC SCHIFF BASES AND THEIR COPPER COMPLEXES INDUCE MODIFICATIONS IN THE ERYTHROCYTE GLUTATHIONE SYSTEM

Posted in 2021, Issue № 12 (114) December 2021, MEDICINE | 0 comments

The effects of new coordination compounds, thiosemicarbazide derivatives (coded compounds with a chemical name: (CMD-4) – 4-ethyl-2- [phenyl (pyridin-2-yl) methylidene] hydrazine-1-carbothioamide]; (CMD-8) – Chloro- {4-ethyl-2- [phenyl (pyridin-2-yl) methylidene] hydrazine-1-carbothioamido} copper]; (CMJ-23) – 4- (3-methoxyphenyl) -2- [1- (pyridin-2-yl) ethylidene] hydrazine-1-carbothioamide] and (CMJ-33) – Chloro- {4- (3-methoxyphenyl) -2- [1- (pyridin-2-yl) ethylidene] hydrazine-1-carbothioamido} copper], on the main indices of erythrocytes glutathione metabolism – total glutathione (tGSH), glutathione peroxidase (GPO), glutathione reductase (GR) and the key enzyme of the pentose phosphate pathway – glucose-6-phosphate dehydrogenase (G-6-PDH) after incubation with the peripheral blood of healthy donors were studied. The significant disturbances in the erythrocyte glutathione cycle expressed by decreasing of the tGSH level by CMJ-33 and CMJ-23, diminushing of GPO by CMD-4 and CMJ-23, reduction of the functional level of G-6-PDH by the all studied compounds (CMD-4, CMD-8, CMJ-33 and CMJ-23), associated with increased tendency of GR activity were registered. The pathogenetic significance of the revealed changes and their possible importance for the development of new treatment strategies for diseases associated with disorders of the glutathione cycle in erythrocytes are discussed.

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ON THE EFFECT OF THE NEUROPEPTIDE COMPOUND ACTH(6-9)-PRO-GLY-PRO ON THE LEVEL OF PRO- AND ANTI-INFLAMMATORY INTERLEUKINS

Posted in 2022, January № 01(115) January 2022, MEDICINE | 0 comments

The current study evaluates the effect of the melanocortin neuropeptide compound ACTH(6-9)-Pro-Gly-Pro on the level of pro- and anti-inflammatory interleukins (IL-1ß, IL-4, IL-6) under conditions of “social” stress. Sensory contact was chosen as an experimental model of “social” stress, as a result of which all animals were divided into aggressors and victims according to the type of behavior. Subsequently, all the rats were divided into groups based on their behavior: control animals (control); animals exposed to stress in the course 20 days (stress); groups of rats that were administered the neuropeptide compound ACTH(6-9)-Pro-Gly-Pro intraperitoneally at a dose of 100 mcg / kg /day in the course of 20 days starting from the 1st day of stress factor exposure. The level of interleukins IL-1ß, IL-4 and IL-6 was determined via enzyme immunoassay. The “social” stress formed in this experiment was accompanied by a change in interleukin production. This fact allows the authors to consider stress as the main inducer of pro-inflammatory cytokines production regardless of factors. An assessment of the effect of melanocortin neuropeptide on the level of IL-1ß, IL-4 and IL-6 under conditions of “social” stress showed that ACTH(6-9)-Pro-Gly-Pro is aimed at restoring the levels of the studied pro- and anti-inflammatory interleukins in stressed animals.

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GENDER – RELATED ASSOCIATION OF M235T POLYMORPHISM OF AGT GENE WITH RISK OF ESSENTIAL HYPERTENSION IN POPULATION FROM CENTRAL RUSSIA

Posted in 2013, Issue August 2013, MEDICINE | 0 comments

The aim of the present study was to explore the association between the M235T polymorphism of the angiotensinogen (AGT) gene and risk of essential hypertension in the population from Central Russia. The study included 1696 subjects: 1115 hypertensive patients and 581 normotensive controls. Genotyping for the AGT M235T polymorphism was carried out by Real-Time PCR.

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PATHOMORPHOLOGICAL FEATURES ХОЛЕСТЕРОЗА GALL BLADDER IN CHILDREN

Posted in 2013, Issue August 2013, MEDICINE | 0 comments

A cholesterosis of a gall bladder (ХЖП) – a disease characterized by metabolic cholesterol with primary his deposition in the wall of the gallbladder (ha). Despite the fact that the first information about ХЖП appeared more than 150 years ago, to date, the disease remains poorly studied. Currently this problem attracted the attention of pediatricians. The emergence of ultrasonic devices with high resolution made possible to detect ХЖП in the early stages, to trace the features of its clinical course. To date, not been studied peculiarities of morphological patterns walls of the gall bladder in children. Not worked through the issues of therapeutic tactics in ХЖП in childhood. In this regard, presented by the authors of the work, dedicated to therapeutic tactics ХЖП in children is important.

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METABOLIC DISORDERS AT A BILE STONE DISEASE IN CHILDREN

Posted in 2013, Issue August 2013, MEDICINE | 0 comments

In the article «Metabolic disorders at a bile stone disease in children» on the basis of own researches revealed changes of lipid metabolism in children with biliary disease, characteristic metabolic syndrome. The interrelation between the indices of lipid metabolism and body mass in children with cholelithiasis. However, the degree of disorders of carbohydrate metabolism did not depend on body mass index. The obtained data allow to assert that obesity is not always a marker of the metabolic syndrome.

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THE ANALYZE OF THE TREATMENT PATIENTS WITH UNCONTROLLED BRONCHIAL ASTHMA

Posted in 2013, Issue August 2013, MEDICINE | 0 comments

It was leaded some researches of treatment patients with the uncontrolled bronchial asthma in the therapeutic departments. And on the base it was done the appraisal of treatment of some patients with BA of different stage illnesses and according with modern recommendations. As a result of research it was exposed some basic mistakes of pharmacology therapy of patients with BA. The mistakes of far deteriorated of current BA and increase of the hospital treatment.

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ADHESIVE-FREE ENDOSCOPIC SEPTOPLASTY

Posted in 2021, Issue № 11 (113) November 2021, MEDICINE | 0 comments

The article describes the development and introduction of a modified method of septoplasty into clinical practice using a sandwich implant consisting of a plate of bone cement coated on both sides with bioresorbable collagen-apatite material “LitAr” impregnated with nanoscale silver and latex tissue glue. The method makes it possible to achieve stable fixation of the implant to the separated sheets of the nasal septum mucosa with glue and to carry out a postoperative period without a tampon with minor reactive phenomena in the nasal cavity. The composite material “LitAr” promotes neoplasm not only of cartilage and bone tissue but also of blood vessels. At the postoperative stage, such negative manifestations as flotation and repeated curvature of the nasal septum are significantly reduced. In addition, the significant adhesion of the implant to the areas of the mucoperichondrium helps prevent bleeding and the formation of hematoma of the nasal septum. The advantage of the proposed implant is also that it excludes the possibility of atrophic phenomena in the nasal septum mucosa.

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LACTATE DEHYDROGENASE CONCENTRATION INDEX IN PREDICTING THE COURSE OF ACUTE CHOLECYSTITIS

Posted in 2021, Issue № 11 (113) November 2021, MEDICINE | 0 comments

The aim of the study was to study the change in the concentration of lactate dehydrogenase in acute cholecystitis. Methods. The authors conduct a simultaneous study of 105 patients who underwent laparoscopic cholecystectomy for acute cholecystitis with various clinical and morphological variants of the course (catarrhal, phlegmonous, gangrenous). Each clinical and morphological variant served as the basis for the formation of the study group. The formed groups of patients were comparable in age, gender and concomitant pathology. Lactate dehydrogenase activity was determined by the standard kinetic colorimetric method for all patients upon admission to the hospital. Statistical processing of the obtained results was carried out using the SPSS Statistics 7.0 program in compliance with the principles of statistical analysis adopted for research in biology and medicine. RESULTS. In patients with acute cholecystitis, the average lactate dehydrogenase content in blood serum amounted to 306±27.9 units/l, which significantly exceeded the average population value of the upper limit of the norm of 250 units/l (p <0,05) The average lactate dehydrogenase level in phlegmonous calculous cholecystitis was 294.3±25.8 units/l, which is significantly higher than in catarrhal (282.6 ±18.3 units/l (p <0.05), and in gangrenous (342.9 ±32.9 units/l), which is significantly higher than in phlegmonous 294.3±25.8 units/l (p <0,05) Thus a direct correlation between increased concentrations of lactate dehydrogenase and the degree of the destructive process in the wall of the gallbladder (r1 between the group with acute catarrhal cholecystitis and clinical comparison groups = 0,87; r2 between the group with acute phlegmonous cholecystitis and clinical comparison groups = 0,087; r3 between the group with acute gangrenous cholecystitis and clinical comparison groups = 0,132; r4 between the group with acute catarrhal cholecystitis and the group with acute phlegmonous cholecystitis = 0,999; r5 between the group with acute catarrhal cholecystitis and the group with acute gangrenous cholecystitis = 0,306; r6 between the group with acute phlegmonous cholecystitis and the group with acute gangrenous cholecystitis = 0,312). CONCLUSION. The data obtained can be used to predict the course of acute calculous cholecystitis and determine treatment measures. RECOMMENDATIONS. Determination of lactate dehydrogenase concentration in the peripheral blood of a patient at the time of hospitalization should be included in the algorithm of preoperative examination in order to predict the severity of acute cholecystitis and determine treatment tactics.

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