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MEDICINE

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ПИ № ФС 77 - 51217, 16+

MAIN ASPECTS OF BIOCHEMISTRY, PHYSIOLOGY OF CARDIAC TROPONINS

Posted in 2020, Issue № 06(96) June 2020, MEDICINE | 0 comments

This review article briefly discusses basic information about the biochemistry and physiology of cardiac troponins. Cardiac troponins (troponin I, T, and C) play an important role in the regulation of contractile function of the heart muscle. Mutations in cardiac troponins are associated with the development of various types of cardiomyopathies, which lead to heart failure and death. The determination of the concentration of cardiac troponins in the blood is used in the diagnosis of some cardiovascular diseases, including acute myocardial infarction, myocarditis, heart failure. This review summarizes the available data on the structure and functions of cardiac troponins, their role in the regulation of myocardial contractions and clinical application.

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EFFICIENCY OF APPLICATION OF EXISTING METHODS FOR FORECASTING SUGGESTED BIRTH DATE AT LOW PERINATAL RISK

Posted in 2020, Issue № 06(96) June 2020, MEDICINE | 0 comments

The currently used methods for predicting the estimated date of delivery (EDD) for uncomplicated single-pregnancy pregnancies of low perinatal risk are characterized by significant differences in the actual and predicted delivery times. The goal of the study is to evaluate the effectiveness of existing methods for predicting the date of delivery. The authors studied 68 episodes of the pregnancy course and childbirth and determined the degree of discrepancy between the predicted and the actual date of independent delivery using the existing methods. Negele method using the first day of the last regular menstruation and the obstetric (28 days) month in the formula, as well as the first fetal ultrasound screening at 11-12 weeks of gestation, were found to be reliable forecasting methods.

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OPTIMIZATION OF TREATMENT OF PATIENTS WITH FUNGAL STOMATIS UNDER BASIS OF REMOVABLE LAMINAR DENTURE IN CASE OF FULL ABSENCE OF TEETH

Posted in 2020, Issue № 06(96) June 2020, MEDICINE | 0 comments

The paper discusses the features of the treatment of patients with fungal lesions of the oral mucosa, using removable laminar denture in case of the complete absence of teeth. The chronic atrophic form of candidiasis of the oral cavity is more common in older people who use dentures. It is recommended to include drugs for the fixation of dentures as protectors for oral candidiasis in the treatment regimen of patients.

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FROM ARTHROSIS TO ARTHRITIS

Posted in 2020, Issue № 06(96) June 2020, MEDICINE | 0 comments

The paper describes a clinical case of the diagnosis and the treatment of rheumatoid arthritis (RA), which has appeared against the background of prolonged osteoarthritis (OA) in an elderly female patient. In it a known fact that it often takes a long time from the moment when the first symptoms of the disease appeared to a final diagnosis. In this age group, this may also be due to comorbidity. More than three diseases are often diagnosed when examining gerontological patients; their mutual influence can change the clinic, the course of joint pathology, and worsen the quality of life as well as a prognosis. Symptoms of one chronic disease may coincide with the clinic of another pathology, manifested by articular syndrome, respectively, q patient will not receive adequate treatment for a long time.

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APPLICATION OF EXTRACORPORAL SHOCKWAVE LITHOTRIPSY AND CONTACT URETEROLITHOTRIPSY IN TREATMENT OF CONCREMENT IN DISTAL URETER

Posted in 2020, Issue № 06(96) June 2020, MEDICINE | 0 comments

A modern approach to the treatment of concrements in a distal ureter intends to choose the minimally invasive techniques. Extracorporeal shock wave lithotripsy (ESWL) and contact ureterolithotripsy (CULT) are the minimally invasive techniques; both are fully recognized among urologists. The goal of our study is to compare the effectiveness of extracorporeal shock wave lithotripsy and contact ureterolithotripsy in the treatment of calculi in a distal ureter. Based on the results of our study, contact ureterolithotripsy is the most suitable treatment for concrements in a distal ureter, and extracorporeal shock wave lithotripsy is a good alternative to the second stage.

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PROFESSIONAL MOTIVATION OF THE BEGINNING MEDICAL NURSES AND ITS INFLUENCE ON THE WORK OF A POLYCLINIC

Posted in 2020, Issue № 06(96) June 2020, MEDICINE | 0 comments

The article presents the analysis of the professional motivation of nurses who are just starting their work in a clinic. In our study, we examined the prospects for professional growth of bachelors who have just graduated from a higher educational institution. The study of the features of the professional motivation of nurses with higher education is very relevant. After all, this type of medical staff has just joined the professional community.

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COMPARATIVE REVIEW OF POSSIBILITIES OF DANIO RERIO (ZEBRAFISH) USAGE AS A MODEL OBJECT IN PRECLINICAL STUDIES

Posted in 2020, Issue № 06(96) June 2020, MEDICINE | 0 comments

Danio rerio (Zebrafish) has been used very widely as a model object in preclinical studies in recent years. This is due to their morphological, physiological, biochemical, genetic and embryological features, as well as economic benefits and the small time spent on their breeding. The goal is to compile available data on the use of Danio rerio (Zebrafish) in preclinical studies. Methods: the authors use the meta-analysis of domestic and foreign articles on the use of Danio rerio in toxicological, pharmacological, embryological and other areas of research. Results: Danio rerio (Zebrafish) can be used in many areas of preclinical drug research. Their use for modeling novelty stress and experimental depression is of particular interest. Conclusions. Danio rerio is a universal model object, that allows cost-effective studies of various pharmacological preparations before they are tested on other models, in particular mammals.

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IMPACT OF INTESTINAL MICROBIOTA ON THE FUNCTIONING OF THE CENTRAL NERVOUS SYSTEM. MECHANISMS OF MICROBIOTA PARTICIPATION IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE

Posted in 2020, Issue № 06(96) June 2020, MEDICINE | 0 comments

In recent years, numerous studies have proven the connection between the development and functioning of the nervous system with the life of the microbiota of the human body. The idea of the axis “microbiota-intestines-brain” is represented, and three closely interconnected mechanisms of its existence are identified: humoral, nervous, and immune. The facts related to the role of microbiota in the pathogenesis of nervous and mental diseases: Alzheimer’s disease, Parkinson’s disease, autism, depression. This view of diseases of the nervous system is not widespread in Russia, and this article presents the main data already obtained by other researchers with the aim of attracting domestic scientists to the subsequent in-depth study of the above diseases, as well as the development and implementation of treatment methods related to the impact on the microflora of the patient and correction of the functions of the nervous system through such an effect.

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MORPHOFUNCTIONAL FEATURES OF IMMUNOCOMPETENT HUMAN PLACENTA CELLS IN TYPE 1 DIABETES

Posted in 2020, Issue № 06(96) June 2020, MEDICINE | 0 comments

Type 1 diabetes mellitus (T1DM) is an autoimmune disease. Pregnancy in the presence of T1DM is associated with risks both for the health of a mother and a fetus. Since women with T1DM may experience an unfavorable outcome of pregnancy due to aberrant immunological adaptation to pregnancy, the study of immunological interactions in pregnant women with T1DM is one of the priority tasks.

Within this study, the authors have studied samples obtained from 80 patients: 40 — from the group with T1DM, 40 — from the control group. Each of the groups was also divided into age subgroups, as well as subgroups of primiparous and multiparous. The authors have selected the macrophage marker CD68, the marker of B-lymphocytes CD20, and the marker of NK cells CD57 as molecules of interest.

This study has revealed differences in the expression of markers of immunocompetent cells between the group of patients with type 1 diabetes and the control group. These results indicate the high significance of the studied markers for assessing the course of pregnancy and the health status of the fetus and mother.

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ANALYSIS OF DENTAL CARE DAMAGES ON MATERIALS OF INTEGRATED FORENSIC MEDICAL EXAMINATIONS

Posted in 2020, Issue № 06(96) June 2020, MEDICINE | 0 comments

Currently, the tendency to increase the number of forensic examinations in civil and criminal suits against healthcare institutions is noted all over the world and in Russia in particular. As part of the research, the authors analyzed the materials of the forensic medical examinations and medical documentation and identified the main shortcomings in the provision of dental care, including the lack of treatment and prosthetics, the lack of necessary diagnostic procedures. A large number of shortcomings in dental treatment were found.

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TRANSCELLULAR TRANSPORT IN LITORAL CELLS OF THE LYMPH NODE AFTER THE IMPLANTATION OF TITANIUM NICKELIDE

Posted in 2020, Issue № 06(96) June 2020, MEDICINE | 0 comments

The implantation of titanium nickelide into the area of the alveolar bone of the lower jaw changes the transcellular transport of micro-vesicles in the littoral cells of regional lymph nodes. Marked changes in the ratio of micro-vesicles were observed on the 7th day of the study after the implantation. These changes are a sign of a decrease in the intensity of mass transfer. The normalization of transcellular transport indicators is noted by 30 days of the study. The results of the study give an idea of the structural foundations of the adaptation of the border structures of the regional lymph node to an implant in the area of the alveolar bone of the lower jaw.

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RACHILYSIS OF FIRST DEGREE SCOLIOSIS IN CHILDREN OF 7-9 YEARS OLD WITH FITBALL EXERCISES

Posted in 2020, Issue № 06(96) June 2020, MEDICINE | 0 comments

The paper presents materials on the application of fitball exercises means for reducing first-degree scoliosis in children of 7-9 years old. The goal of the study is the physical rehabilitation of children of 7-9 years old with first-grade scoliosis using fitball exercises in therapeutic gymnastics. After applying the improved technique, the authors revealed a significant improvement in the condition of the musculoskeletal system, a decrease in the difference in the depth of the waist triangles, a significant increase in the strength of the muscles of the back and abdominal muscles, speed and strength increased.

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FORECASTING DEVELOPMENT OF PULMONARY HYPERTENSION IN MEN OF YOUNG AND MIDDLE AGES IN SUBACUTE PERIOD OF MYOCARDIAL INFARCTION

Posted in 2020, Issue № 06(96) June 2020, MEDICINE | 0 comments

Relevance. Pulmonary hypertension (PH) worsens the prognosis of myocardial infarction (MI).

Goal. To establish the most significant risk factors for the development of PH in the subacute period of MI for its prognosis.

Methods and materials. The study included 451 men aged 19-60 with MI. Patients were tested according to the standard diagnostic algorithm, including complex echocardiography, in the first 48 hours and at the end of the third week of the disease. The group under study consisted of 84 patients with PH that occurred at the end of the third week of the disease with an initially normal level of mean pressure in the pulmonary artery (MPPA). The control group included 367 patients with a normal level of MPPA in both phases of the study or normalization of this indicator at the end of the subacute period of the disease. Using correlation (according to T. Spearman) and multivariate analysis of variance (ANOVA) from the analytical base, the indicators were selected with reliable relationships with the levels of MPPA, or a significant effect on the risk of PH at the end of the subacute MI.

Results. According to the obtained results, the most significant factors for the development of PH in the subacute period of MI are metabolic (plasma, sodium, potassium, chlorine; glucose and lipid concentrations) and hemodynamic (heart rate (HR), diastolic blood pressure, sizes of the left atrium and final diastolic – the right ventricle, indices of the final systolic and diastolic volumes of the left ventricle, cardiac, total pulmonary resistance, the presence of regurgitation on the aortic valve) parameters.

Conclusions. The use of the combination of these factors for prognostic modeling in the first hours of myocardial infarction will make it possible to identify among men under the age of 60 with a high risk group for the development of PH in the subacute period of myocardial infarction with the aim of timely conducting preventive diagnostic and therapeutic measures.

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STATURAL-WEIGHT VALUES OF BABIES WITH SOME CASES OF LOCALIZATION OF PLACENTA AND LOW PERINATAL RISK

Posted in 2020, Issue № 05(95) May 2020, MEDICINE | 0 comments

The location of the placenta in the uterus is of great importance for the devel-opment of the fetus, which is associated with the intensity of blood supply to different parts of the uterus. The location of the placenta in an anterior seg-ment of the pregnant uterus (p <0.05) is statistically significant. The authors studied statural-weight values of 105 newborns, depending on some options for the localization of the placenta in a uterus. The mass of newborns, when the placenta is located on the back wall, is significantly higher compared to other zones.

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RANKING AND CLUSTERING OF VERBAL ESTIMATES OF THE INCIDENCE RATE OF SYMPTOMS OF THE NOVEL CORONAVIRUS INFECTION (COVID-19), COMMON COLD, AND INFLUENZA

Posted in 2020, Issue № 05(95) May 2020, MEDICINE | 0 comments

An ordinal scale has been developed that reflects the correspondence of verbal assessments of the novel coronavirus infection, common cold, and influenza symptoms incidence to digital analogues, namely: “No” — 0 points; “Rare” — 1 point; “Sometimes” — 2 points; “Common” — 3 points. A cluster analysis of digital analogues showed the following results: (1) the maximum distance (5.39) is observed between COVID-19 and common cold; (2) the minimum distance (3.00) is observed between COVID-19 and influenza; and (3) the distance (5.29) between common cold and influenza is intermediate. Entropy (in bits) calculated for the incidence of verbal characteristics of the frequency of symptoms of the three diseases has the following meanings: (1) for COVID-19 the entropy is 1.7610; (2) for common cold it is 1.8465; and (3) for influenza it is 1.4855.

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FEATURES OF FIRST AID FOR CHILDREN AFTER ACCIDENT

Posted in 2020, Issue № 05(95) May 2020, MEDICINE | 0 comments

The development of technology and the increase in speeds of movement leads to the fact that as a result of road traffic accidents, injured people may get injuries that vary both in character and in severity. First aid for injured people with multiple and combined trauma (polytrauma) requires training and specific skills. It is necessary to increase the professional competence of specialists providing first-aid for victims of accidents to achieve the goals of reducing mortality after road traffic accidents. Particular attention in the preparation process must be paid to the features of providing assistance to children affected by road accidents.

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AWARENESS AMONG PATIENTS OF MEDICAL GENETICS CONSULTATIONS ON RISK FACTORS OF HEREDITARY AND CONGENITAL DISEASES IN CHILDREN

Posted in 2014, Issue October 2014, MEDICINE | 0 comments

The article presents the results of scientific studies, which assess the awareness of patients about risk factors for hereditary and congenital diseases in unborn children. Determined that the patients treated in the medico-genetic consultation retrospectively, when they already have genetic problems that every sixth patient is age a risk (ages 36-45 years old) birth of a sick child. A study revealed that the majority of patients (60.7%) and low awareness of the risk factors that may contribute to the creation of hereditary and congenital diseases in unborn children.

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QUALITY OF LIFE AT PATIENTS WITH DIABETES 2 TYPES

Posted in 2014, Issue October 2014, MEDICINE | 0 comments

In the article -quality life in patients with type 2 diabetes, comparison of a control group of healthy people of the same age. The influence of the length of the disease on quality of life of people suffering from type 2 diabetes.

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STRUCTURE OF COMPLICATIONS AND METHODS OF DELIVERY IN PREGNANT WITH CHOLESTATICHEPATOTOXICITY

Posted in 2014, Issue October 2014, MEDICINE | 0 comments

The aim of this work was to study the structure and methods of delivery complications in pregnant women with cholestatic hepatosis.

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PREGNANCY AND BIRTH OUTCOMES IN PREGNANT WOMEN WITH VAGINAL CANDIDIASIS

Posted in 2014, Issue October 2014, MEDICINE | 0 comments

The aim of this work was to study the spectrum of the microbial flora of the vaginal discharge and its sensitivity to therapeutic drugs, as well as the outcome of labor in pregnant women suffering from vaginal candidiasis.

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