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MEDICINE

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ПИ № ФС 77 - 51217, 16+

ANALYSIS OF RISK FACTORS OF BREAST CANCER DEVELOPMENT

Posted in 2019, Issue №3(81) March 2019, MEDICINE, Выпуск №3(81) Март 2019 | 0 comments

More than 1.1 million cases of morbidity and more than 410,000 breast cancer deaths (BC) are diagnosed worldwide every year. The systematic review and analysis of the study of the influence of possible risk factors and causes of this type of cancer by the statistical materials of the EMBASE and MEDLINE databases are essential. The study of risk factors for the incidence of breast cancer was carried out on a global scale, considering geographical and temporal variations in different regions of the world.

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CLINICAL CASE OF LATE DIAGNOSTICS OF CHARDZH-STROSS DISEASE

Posted in 2019, Issue №3(81) March 2019, MEDICINE, Выпуск №3(81) Март 2019 | 0 comments

Синдром Чарджа-Стросс – эозинофильное гранулематозное воспаление с вовлечением дыхательных путей и некротизирующий васкулит, поражающий сосуды мелкого калибра, сочетающийся с бронхиальной астмой и эозинофилией. Представленный клинический случай демонстрирует трудности своевременной диагностики этого клинического состояния и эффективную терапию глюкокортикоидами и цитостатиками. Это заболевание весьма редко встречается в клинической практике, однако врачи различных специальностей, в первую очередь пульмонологи, ревматологи, терапевты должны помнить о возможности его выявления у своих пациентов.

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ESTIMATION OF CLINICAL EFFICIENCY OF SPINAL ANESTHESIA DURING OPERATIONS ON EXTERNAL PREGNANCY

Posted in 2019, Issue №3(81) March 2019, MEDICINE, Выпуск №3(81) Март 2019 | 0 comments

Spinal (subarachnoid) anesthesia is one of the most common methods of anesthesia during surgical interventions performed in a planned and emergency order on the organs of the abdominal cavity, small pelvis and lower extremities. Being a central conductive blockade, it allows to provide stable segmental analgesia, to prevent operational stress reactions, to ensure an adequate level of regional muscle relaxation. High reliability of the analgesic effect of spinal anesthesia is carried out by blocking the efferent and afferent pathways with the development of favorable metabolic and endocrine effects of segmental blockades, which ensures high reliability of this type of anesthesia at all stages of the operation and allows for stability of the intraoperative and postoperative periods.

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PANORAMIC VIEW OF ANTI-AGING PROBLEMS: FROM A CELL TO THE PERSONAL PRODUCT

Posted in 2019, Issue №3(81) March 2019, MEDICINE, Выпуск №3(81) Март 2019 | 0 comments

Aging is a natural process characterized by the gradual loss of the body’s physiological integrity from the point of view of medicine and biology, which leads to the impairment of its functions and increases the risk of death. Scientists all over the world have been trying to solve the problem of aging throughout the history of mankind, [8]. Recently, the approach to aging and anti-aging technologies has changed dramatically due to the increasing amount of research in the field of genetic engineering, cell technologies and regenerative medicine.

The main goal of anti-age medicine is the development of a comprehensive, personalized approach to solving anti-aging tasks including effects at all levels of aging.

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ROLE OF SOCIAL NETWORKS IN PROMOTING HEALTHY LIFESTYLE

Posted in 2019, Issue №2(80) February 2019, MEDICINE | 0 comments

The article shows the public interest in health promotion in social networks. The authors conducted a comparative analysis of the posts dedicated to the promotion of a healthy lifestyle in Romanian and English from 10 communities on Facebook. The following areas were studied: healthy eating, bad habits, exercise, environment, infectious diseases, somatic disorders, beauty. The topic of health promotion on Facebook is interesting for users and is an effective platform for the intervention of public health specialists.

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INFLUENCE OF ANTIHYPERGLYCEMIC DRUGS AND DRUGS FOR TREATMENT OF DIABETIC POLYNEUROPATHY ON TREATMENT OF PAIN SYNDROME

Posted in 2019, Issue №2(80) February 2019, MEDICINE | 0 comments

Currently, diabetes takes theleading position among the endocrine pathologies. According to WHO, there will be 380 million of patients with diabetes by 2025, and 435 million people by 2030. Moreover, about 90% of patients suffer from type 2 diabetes mellitus. The most common diabetic complications include diabetic polyneuropathy, the frequency of its occurrence is about 50%. When this takes place, the nerve fibers are damaged, various types of sensitivity are lost, and there is severe pain syndrome. As a result, patients need to take long-term drug therapy for the treatment of painful forms of diabetic polyneuropathy, which often belong to the group of anticonvulsants. Anticonvulsant drugs interact with hypoglycemic agents and lead to the development of adverse events.

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ACHIEVING TARGET VALUES OF ARTERIAL PRESSURE IN HYPERTENSIVE DISEASE THROUGH FIXED COMBINATION OF AMLODIPINE AND PERINOPRIL ARGININE

Posted in 2019, Issue №1(79) January 2019, MEDICINE | 0 comments

The main aim of the work was to study the effect of free and fixed combinations of amlodipine, angiotensin converting enzyme inhibitor perindopril and dihydropyridine calcium antagonist, on blood pressure (BP), compliance and quality of life of patients with hypertensive disease (HD). The study included 92 patients suffering from HD of II and III stages. Changes in blood pressure indices were compared including the variability of blood pressure and criteria for adherence to treatment and quality of life. Fixed combined antihypertensive therapy allows achieving target blood pressure in most patients with hypertension of stage II and stage III with high and very high risk of developing cardiovascular complications (CVC) and ensuring high adherence to therapy.

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A RARE CLINICAL CASE OF ECHINOCOCCOSIS OF SPINAL BRAIN SHELL

Posted in 2019, Issue №1(79) January 2019, MEDICINE | 0 comments

The paper provides a brief description of echinococcosis as a nosological unit, as well as information on the prevalence of this disease in Russia. A rare clinical case of echinococcosis of the spinal cord membranes, registered in the Ryazan Regional Clinical Hospital is also described. In this case, we managed to diagnose the disease at a late stage with the development of signs of compression of the spinal cord. In order to diagnose this pathology, magnetic resonance imaging (MRI) must be used; it allows us to detect the presence of formations in the spinal canal. In doubtful cases, the formulation of the reaction of passive hemagglutination (RPHA) should be applied to detect echinococcal antibodies. Currently, the only effective treatment is early surgery.

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ON THE QUESTION OF SOME CORRELATION LINKS OF THE METABOLIC SYNDROME AND NONALCOHOLIC FATIAL LIVER DISEASE

Posted in 2019, Issue №1(79) January 2019, MEDICINE | 0 comments

This review of the literature is devoted to the correlation relationships of metabolic syndrome and non-alcoholic fatty liver disease (NAFTLD). Today, the world practice of research requires a comprehensive approach to the study of diseases, due to the multifactorial approach. Perhaps the most significant in the formation of NBBP are: insulin resistance, type 2 diabetes, dyslipidemia, obesity, and they, in turn, are the most important components of the metabolic syndrome. But still a debatable issue are steatal changes in the liver, which can act as an initiating component of the metabolic syndrome.

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PATHOMORPHOLOGY OF HEMORRHAGIC FEVER WITH RENAL SYNDROME

Posted in 2019, Issue №1(79) January 2019, MEDICINE | 0 comments

The paper presents the results of pathological studies of hemorrhagic fever with renal syndrome. Particular attention is paid to the endothelium damage of blood vessels, as a trigger mechanism for all pathological processes in the body, and above all, violations of rheological blood disorders: from sludge-phenomenon to stasis and agglutination of erythrocytes into homogeneous mass with the formation of microthrombi. Lymphocytes, monocytes, as well as vascular endothelium proliferation factor play a significant role in the damage of the vascular wall. Sharp increase in the penetrability of the vascular wall developing at the same time leads to intensive edema, which damages the parenchyma of the organs even more.

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FIXED COMBINATIONS FOR SUGAR-DECREASING PREPARATIONS: APPLICATION STANDARDS IN THE RUSSIAN FEDERATION, USA AND EUROPE

Posted in 2018, Issue №12(78) December 2018, MEDICINE | 0 comments

The relevance of the treatment of diabetes mellitus type II is considered in the article. The disadvantages of monotherapy and the advantages of using rational hypoglycemic drugs are noted. Comparative analysis of the most used groups of drugs, as well as fixed combinations in Russia, Europe and the United States is performed. Potential reasons for the differences in their assortment are established. Possible rational combinations of hypoglycemic drugs for the treatment of diabetes mellitus type II in Russia are proposed.

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MAIN FEATURES OF ERYTHROCYTES MORPHOLOGY IN PERSONS DEAD OF HYPOTHERMIA

Posted in 2018, Issue №12(78) December 2018, MEDICINE | 0 comments

This paper presents the results of the study of erythrocytes morphology of the persons dead of hypothermia under the temperature conditions of Yakutia (below -40 °C) with the help of scanning electron microscopy (SEM). Characteristic features of the erythrocyte morphology were revealed, and experimental data were compared before and after prosection. Before prosection, discocytes prevailed and only 15% were altered erythrocytes, that is – echinocytes. After prosection, the percentage of echinocytes more than doubled. The results of the study can be used in the formation of fundamental ideas about cellular changes in critical states and possible mechanisms for the recovery of cells and their functional properties.

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STUDY OF BACILLUS ATROPHAEUS INACTIVATION WITH CLEAN AND MODIFIED CARBON DIOXIDE

Posted in 2018, Issue №12(78) December 2018, MEDICINE | 0 comments

В работе рассматривается возможность использования сверхкритических флюидов в качестве стерилизующего агента изделий медицинского назначения. Проведены исследования по инактивации Bacillus atrophaeus с применением чистого и модифицированного сверхкритического диоксида углерода. Установлено, что при определенных термодинамических параметрах модифицированный СО2 является эффективным стерилизующим агентом в отношении спор Bacillus atrophaeus. Определена длительность достижения полной инактивации.

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ASSESSMENT OF SAFETY AND EFFICIENCY OF SELECTIVE PLASMA SORPTION AND PLASMA EXCHANGE AT HEPATISM IN PATIENTS WITH OBSTRUCTIVE JAUNDICE

Posted in 2018, Issue №11(77) November 2018, MEDICINE | 0 comments

Extracorporeal haemocorrection and detoxification methods for hepatic insufficiency in patients with obstructive jaundice are effective and need to be assessed for their safety in preoperative and postoperative periods, in particular, against the background of a lengthy period of jaundice. The safety and efficiency of selective plasma sorption and plasma exchange at hepatism in patients with obstructive jaundice was evaluated in 32 patients. Of these, 14 patients underwent plasma exchange, 18 patients underwent selective plasma sorption. The level of total bilirubin before the treatment was from 285 µmol/L to 589 µmol/L. Each patient underwent 3 plasma exchange procedures with the removal of 1 VPC (volume of plasma circulation). The removed plasma volume was filled with fresh donor frozen plasma and 5% solution of albumin in a 1:1 ratio was introduced. Heparin was used for anticoagulation. In another group, each patient underwent 3 procedures with a treatment of 2 VPC per procedure. In this case, one procedure was carried out directly on the eve of the operation, and the other two – in the early postoperative period. Heparin was used for anticoagulation. We studied the patient’s condition and the dynamics of biochemical parameters before the procedure, during the procedure and at the end of the procedure. During plasma exchange, there was a decrease in the levels of total bilirubin by 38.5 ± 6.4%, conjugated bilirubin by 37.2 ± 5.0%, unconjugated bilirubin by 27.5 ± 2.3%, ALT – by 23.4 ± 4, 1%, GOT – by 30.4 ± 3.5%, bile acids by 30.3 ± 5.4%, and alkaline phosphatase by 34.2 ± 3.5% by the end of the procedure. There was a decrease in total bilirubin after selective plasma sorption by 39.8 ± 3.8%, conjugated bilirubin by 38.2 ± 18%, and unconjugated bilirubin by 32.5 ± 11.9%, ALT – by 23.5 ± 3.4 %, GOT – by 37 ± 2.3%, bile acids by 31.4 ± 2.8% by the end of the procedure. However, other biochemical parameters did not change significantly. In the course of the plasma sorption procedure, none of the patients had hemorrhagic complications.

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INFLUENCE ON HEALTH AND SOCIO-ECONOMIC EFFECTS OF DISEASE INCIDENCE OF CHICKENPOX IN THE REPUBLIC OF MOLDOVA

Posted in 2018, Issue №11(77) November 2018, MEDICINE | 0 comments

The article contains epidemiological analysis of the incidence of chickenpox in the Republic of Moldova from 1985 to 2017. It is a longitudinal descriptive retrospective study. The results of the study showed that long-term incidence of chicken pox from 2003 to 2016 had a pronounced upward trend in the Republic of Moldova. 60.19% of the respondents had chickenpox in light form, and 39.18% of patients had chickenpox of medium severity. 44.17% of hospitalized patients had chickenpox of medium severity, 25.77% of patients had a moderately severe chickenpox in association with other diseases, 9.20%, and 20.86% of patients had severe chickenpox in association with other diseases.

The average cost per patient for outpatient chickenpox treatment is 51.1 dollars. The average cost of treating one patient hospitalized with chickenpox is 150.15 dollars. The average cost of treating one patient with chickenpox is 100.63 dollars.

The expenses connected with a lethal case comprise 167407.74 dollars. The costs associated with the purchase of Varivax mono-vaccine comprise 743997.49 dollars which is 1.64 times lower than the annual costs associated with the incidence of chickenpox in the Republic of Moldova, which is 1222407.15 dollars. As for the costs associated with the acquisition of the ProQuad combination vaccine, which is 474476.68 dollars, they are 2.58 times less than the annual losses associated with the incidence of chickenpox.

The highest costs/losses per capita as a result of the incidence of chickenpox are recorded in Bălți – 2.5 dollars, and the costs/expenses per capita for vaccinating children from 1 year of age in Bălți are 13.43 times less and comprise 0.19 dollars.

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THE SOCIO-ECONOMIC IMPACT OF POST CARDIAC SURGERY PATIENTS WITH SEPTIC-PURULENT NOSOCOMIAL INFECTIONS

Posted in 2018, Issue №11(77) November 2018, MEDICINE | 0 comments

Cardio-surgical septic-purulent nosocomial infections represent a major problem for public health. Most hospital infections are those related to diagnostic explorations, related procedures and/or medical devices.

The study has shown that the average cost of treatment per capita represents 29,238.23 MDL for patients without cardio-surgical SPNI, 34,465.40 MDL for patients with cardio-surgical SPNI, 53,832.84 MDL for patients with cardio-surgical SPNI with associations. Additional costs related to treatment and the stationary stay of cardio-surgical patients with SPNI is a total of 9,851,016.18 MDL. The total amount of lost years in deceased post cardio-surgical patients with SPNI for the years 2010-2013 is 293 years, representing an economic loss to the Republic of Moldova of 5,137,101.03 MDL. Full economic impact due to morbidity through post cardio- surgical SPNI during the study period 2010-2013 is a total of 53,111,959.61 MDL.

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PSEUDO-ADAPTATION IN PATIENTS WITH BILATERAL PSEUDOPHAKIA

Posted in 2018, Issue №11(77) November 2018, MEDICINE | 0 comments

The results of the treatment of 83 cataract patients aged 46 to 83 (68±6.3) after bilateral phacoemulsification of cataract with the implantation of an elastic intraocular lens using the “monovision” system were studied. The analysis of the phenomenon of pseudo-adaptation based on measured anisometropia was carried out. As a result, the visual acuity of both eyes separately in all patients with the correction comprised 0.9-1.0, binocular without any correction — 0.8-1.0 (0.86±0.13). The average numbers of the leading eye’s refraction were (-) 0.08±0.27D, paired – (-) 1.46 ± 0.54D. At close range (binocular without correction), visual acuity averaged 0.67±0.09±, on the average – 0.84±0.07.

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STUDY OF BACILLUS ATROPHAEUS INACTIVATION WITH CLEAN AND MODIFIED CARBON DIOXIDE

Posted in 2018, Issue №12(78) December 2018, MEDICINE | 0 comments

The authors consider the possibility of the use of supercritical fluids as sterilizing agents for medical devices. They conducted studies on the inactivation of Bacillus atrophaeus with pure and modified supercritical carbon dioxide. It has been found that under certain thermodynamic parameters, modified CO2 is an effective sterilizing agent against Bacillus atrophaeus spores. The duration of achieving complete inactivation is also determined.

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CORRECTION OF SYSTEMIC INFLAMMATION WITH POSITIONAL COMPRESSION SYNDROME

Posted in 2018, Issue №10(76) October 2018, MEDICINE | 0 comments

The results of the treatment of 11 patients with acute renal damage with positional compression syndrome are presented in the paper. Combined plasma filtration and adsorption (SPFA) was used in complex therapy. The analysis of the effectiveness of the SPFA was also carried out. The dynamics of proinflammatory and anti-inflammatory cytokines was studied. A significant decrease in the level of TNF-a, IL-1β, IL-6, IL-10 was revealed. After SPFA, there is a significant decrease in proinflammatory cytokines of TNF-a by 50.4%, interleukin IL-1β by 52.6%, IL-6 by 37.4%, and a decrease in the level of anti-inflammatory cytokine IL-10 by 43, 9%.

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MAIN FEATUES OF CLINICAL COURSE OF PERIPHERAL ATHEROSCLEROSIS UNDER CONDITIONS OF TERRITORY CONTAMINATED BY TECHNOGENIC RADIONUCLIDES

Posted in 2018, Issue №10(76) October 2018, MEDICINE | 0 comments

The main features of clinical course of peripheral atherosclerosis in males who permanently live in the mountains near uranium tailings were studied. It is established that these patients fall ill earlier in comparison with the control group, which indirectly indicates the dominating impact of environmental factors on the pathological process. The vascular lesion located in the popliteal pedidial segment was more characteristic for this category of people. In comparison with the control group living in an ecologically “clean” zone, patients of the main group had the femoropopliteal shunt procedures more often which indirectly indicates the involvement of the distal vascular bed into the pathological process.

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