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MEDICINE

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ПИ № ФС 77 - 51217, 16+

EFFECTS OF THYROID DYSFUNCTION AND CORTISOL IMBALANCE ON THE COGNITIVE AND MENTAL DEVELOPMENT OF CHILDREN WITH AUTISM SPECTRUM DISORDER

Posted in 2020, Issue № 11(101) November 2020, MEDICINE | 0 comments

The article establishes causal relationships and statistically proves correlations between hypothyroidism and/or cortisol imbalance in children with autism spectrum disorder, and between their negative behavior and mental and cognitive development disorders. The paper illustrates that the correction of hormonal disorders leads to a decrease in negative behavior and a noticeable improvement in mental state and cognitive functions, and proposes successful therapeutic strategies for all types of hormonal disorders.

The paper advises clinicians to pay attention to subclinical forms of hormonal disorders in children with autism spectrum disorder. Parents and special educator working with children are advised to keep in mind that negative behavior and delay in the development of a child may be directly related to hormonal imbalance.

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TREATMENT OF DYSCIRCULATORY ENCEPHALOPATHY OR CHRONIC BRAIN ISCHEMIA AS A WAY TO ELIMINATE DEPRESSIVE DISORDERS

Posted in 2020, Issue № 11(101) November 2020, MEDICINE | 0 comments

Depression is considered one of the leading disorders in the world according to the disability and morbidity statistics. However, due to the fear of stigmatization, more than 264 million people suffering from depressive disorders do not seek professional help in the treatment of depression. Despite the fact that there is a huge number of innovative methods for treating many disorders, the prevention and treatment of depression is still only at the level of development. Reduced performance, loss of interest in life, lack of energy, slowness, decreased concentration, and other cognitive disorders are detected in depressive disorders. Scientists suggest that depressive disorders are considered the first signs of dyscirculatory encephalopathy, or chronic brain ischemia according to ICD-10. It is noted that symptoms of depression can be identified at the first stage of dyscirculatory encephalopathy.

The article suggests that timely diagnosis of dyscirculatory encephalopathy through proper cognitive assessment and further treatment aimed at treating encephalopathy will help prevent the development of depressive disorders in its early stages.

At this point in time, according to the results of the review of scientific articles and studies investigating the causes of vascular encephalopathy as well as the preconditions of occurrence of this disease, there is no available studies that describe the treatment of depressive disorders through treatment of dyscirculatory encephalopathy. However, the existence of such studies is necessary because the topic of the relationship between depressive disorders and dyscirculatory encephalopathy is relevant and insufficiently studied.

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CHANGES IN LIPID METABOLISM IN CHILDREN OF STAVROPOL KRAI SUFFERING FROM CYSTIC FIBROSIS

Posted in 2020, Issue № 11(101) November 2020, MEDICINE | 0 comments

Cystic fibrosis is a severe monogenic disease characterized by a deterioration of the patient’s health and their shortened lifespan. Lipids ensure the normal course of cellular metabolism, stimulate nonspecific immunity, and are precursors of the steroid and reproductive hormones. A study of lipid metabolism in children of Stavropol Krai suffering from cystic fibrosis reveals pronounced dyslipidemia. In the form of pancreatic insufficiency, an inverse, statistically significant relationship between fecal elastase and HDL, temporary adrenal insufficiency and a decrease in cholesterol expenditure on steroid synthesis can be observed, which, in turn, can exacerbate the obstructive syndrome.

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MEDICAL ASPECTS OF FUNCTIONAL DISORDERS OF THE URINARY SYSTEM IN PATIENTS WITH COVID-19

Posted in 2020, Issue № 11(101) November 2020, MEDICINE | 0 comments

The article deals with the problem of new coronavirus infection (COVID-19) and describes the ways of its transmission as well as the groups of people who are exposed to the most serious forms of the infection. The research describes the functional state of the urinary system in patients with COVID-19 on inpatient treatment in Saratov. The description is made on the basis of such studies as complete blood count, urinalysis, biochemical blood test, Nechiporenko test. In some patients, an increase in their urine specific gravity, sugar, acetone, formed elements and salts were detected. When assessing the biochemical blood test in patients with COVID-19, an increase in urea and creatinine levels was observed. Thus, the data obtained as a result of the study provide an opportunity to determine the direction of work on the diagnosis, treatment and prevention of the infection in order to prevent the development of multiple organ failure in patients with COVID-19.

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HEALTH AND PHYSICAL DEVELOPMENT CONDITION OF PRESCHOOL CHILDREN

Posted in 2020, Issue № 11(101) November 2020, MEDICINE | 0 comments

The article presents information and statistical data with regard to the health and physical development condition of preschool children living in Astrakhan. The analyzed data was extracted from medical source records. The analysis of morbidity illustrates that the diseases of the musculoskeletal system and congenital pathology are ranked the highest. It is necessary to develop prenosological diagnostics of health aimed at identifying initial deviations in the medical condition before the appearance of signs of pathology.

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HEALTHY SUPPORT OF ADAPTIVE PHYSICAL CULTURE CLASSES

Posted in 2020, Issue № 11(101) November 2020, MEDICINE | 0 comments

The report reveals the stages of medical support for adaptive physical education classes with disabled students and students with disabilities. In educational institutions, these classes are conducted in the form of electives, in small groups, since not only the attention of the teacher is needed, medical support of classes is also important, and the work of a psychologist with students. One of the defining factors of health is the culture of movement. This is clearly understood by children with disabilities and / or limited health opportunities. It is important that adaptive physical culture classes contribute to the preservation and strengthening of their health, improvement of the quality of life, the formation of motivation to engage in medical physical culture.

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STUDY OF CLINICAL EFFICACY AND SAFETY OF INJECTABLE FORMS OF CHONDROITIN SULFATE

Posted in 2014, Issue December 2014, MEDICINE | 0 comments

Our purpose was to research clinical efficiency, tolerability and safety of injectable “Hondrogard”. We studied 30 patients with osteoarthritis of the knee. We revealed that “Hondrogard” was as effective as “Alflutop”. Those medicines reduced pain, stiffness and NSAIDs consumption, improved function of the joints, laboratory markers of inflammation. We didn’t note severe adverse effects.

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INFLUENCE DECREASE IN BODY WEIGHT IN PATIENTS WITH OSTEOARTHRITIS ON CARBOHYDRATE METABOLISM AND C-REACTIVE PROTEIN

Posted in 2014, Issue December 2014, MEDICINE | 0 comments

Leptin level was determined in the serum of 130 patients with osteoarthritis. We studied dynamics markers of carbohydrate, leptin level in serum and C-reactive protein to lower before and after weight loss in patients with osteoarthritis.

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ISHEMIC HEART DISEASE: DYNAMICS OF MORBIDITY

Posted in 2014, Issue December 2014, MEDICINE | 0 comments

The article is devoted to the problem of ischemic heart disease a major cause of death in the world. Reviewed its place in the structure of general morbidity due to cardiovascular disease as an example of the Kirov region. Based on these statistics analyzed the role of modifiable and non-modifiable risk factors in the development of pathology. In considering the situation in the Volga Federal district some positive dynamics in solving the problem is showed. The efficiency of the active demographic of health policy.

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ANALYSIS OF PHYSICAL DEVELOPMENT IN PRETERM INFANTS

Posted in 2014, Issue December 2014, MEDICINE | 0 comments

The article deals with – physical development of children with extremely low birth weight, very low birth weight and low birth weight, depending on the subsidies given protein centile curves.

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ASSESSMENT OF PAIN IN THE TREATMENT OF PATIENTS WITH PACHOVYMI HERNIAS

Posted in 2014, Issue December 2014, MEDICINE | 0 comments

The article deals with the application of different options of local anesthesia, in order to optimize the choice of anesthesia in order to improve the quality of life of patients after inguinal hernia repair. The efficiency of modern local anesthetics with endoprosthesis.

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SEARCH OPTIONS FOR THE TREATMENT OF MALIGNANT BRAIN TUMORS

Posted in 2014, Issue December 2014, MEDICINE | 0 comments

The article discusses mikrosimptomatika disease “astroblastoma stage IV” risk factors of tumor development, the variability of treatment with the help of new methods based on the antigenic properties of the tumor, and the prognosis of its holding, the statistics on survival of patients with advanced disease.

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ANTIBIOTIC SENSITIVITY OF CONDITIONALLY PATHOGENIC MICROORGANISMS IN MIXED BACTERIAL-CHLAMYDIA INFECTION IN WOMEN OF REPRODUCTIVE AGE

Posted in 2020, Issue № 10(100) October 2020, MEDICINE | 0 comments

The research of urogenital chlamydial infections related to sexually transmitted infections is of the greatest importance in the study of secondary infertility. It has a negative impact on reproductive health, often causing serious complications, like infertility, miscarriage, etc. Thus the frequency and level of miscarriage in reproductively active population is about 25%. Moreover, genital infection is the main cause of such complications. The lack of effect of antibiotic therapy associated with antibiotic resistance leads to the fact that the disease continues to progress and becomes more severe, its treatment becomes even more difficult.

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PSYCHOSOMATIC FEATURES OF HEALTH OF WORKERS IN CHEMICAL PRODUCTION

Posted in 2020, Issue № 10(100) October 2020, MEDICINE | 0 comments

The transition from the absolute safety concept to the assessment of working conditions through the definition of occupational risk was implemented in 2017. They made the changes to the Federal Law of March 30, 1999 No. 52-FZ On the Sanitary and Epidemiological Welfare of the Population, establishing the grounds for calculating and assessing risks to human health. According to the World Health Organization (WHO: Fact Sheet, May 2019), negative work environments lead to physical and mental health problems, harmful use of psychoactive substances or alcohol, missed work, and decreased productivity. The problem of active longevity and working capacity in its development needs new approaches to assessing and maintaining somatic and mental health; their close relationship is confirmed by numerous studies. This is of particular relevance for those workers, the working conditions of which are considered to be harmful. The study indicates risk factors and interactions between the somatic and mental components, depending on the working conditions in the chemical industry. The influence of the chemical factor and the intensity of the labor process on the formation of mental disadaptation is shown as well.

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MENTAL DISORDERS INCURRED BY MINORS VICTIMS AS A RESULT OF OFFENCES OF A SEXUAL ABUSE

Posted in 2014, Issue November 2014, MEDICINE | 0 comments

This article describes mental disorders and their main clinical characteristics that were found in victims of sexual abuse. The article examines the factors that contribute to the clinical picture of the available post-traumatic disorders on stage, as well as their influence on adaptation.

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THE PROBLEM OF APPLYING “OFF-LABEL” MEDICATION IN RUSSIA

Posted in 2020, Issue № 09(99) September 2020, MEDICINE | 0 comments

The article comprehensively examines the concept of “off-label” therapy, which is missing from the Russian legislation. The authors consider the procedure and criteria for its application in Russia and other countries. The article analyses the court practice on the usage of non-instructed medication and examines the opinion of Russian doctors on this issue. The authors conclude that it is necessary to fix the concept of “off-label” therapy in Russian legislation and to expand the criteria for using “off-label” medication.

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ON THE MATTER OF LIPID METABOLISM PATTERNS TYPICAL FOR THE YOUNG AND MIDDLE-AGED MEN HAVING PULMONARY HYPERTENSION FORMED IN THE SETTING OF MYOCARDIAL INFARCTION

Posted in 2020, Issue № 09(99) September 2020, MEDICINE | 0 comments

Topicality. The regularities and values of changes in lipid metabolism accompanying pulmonary hypertension (PH), formed in the setting of myocardial infarction (MI), are understudied.

The purpose. To evaluate the changes in lipid metabolism and their significance for the men less than 60 years having PH formed during the subacute period of MI to clarify its formation mechanisms and to develop preventive measures.

Materials and methods. The study included 436 men aged from 32 to 60 having MI. Patients underwent a standard diagnostic and therapeutic procedure, including the mandatory lipid profile, during the first 48 hours (1) and at the end of the third week of the disease (2) in the setting of initiated atorvastatin and rosuvastatin treatment. The study group consisted of 86 patients (average age 51.1±6.9 years) having PH, which developed at the end of the third week of the disease at the initially average level of mean pulmonary arterial pressure (mPAP). The control group included 350 patients (51.4±6.1 years of age, p=0.98) with normal mPAP levels during both phases of the study or normalization of this indicant at the end of the subacute period of the disease. A comparative analysis was performed of lipid metabolism indicants in the selected groups and their impact on the risk of PH development during the subacute period of MI.

Findings. The study group demonstrated lower than the control group values of the atherogenic index (4.5±2.0 and 5.6±2.3; p=0.006) and total cholesterol (TC)/high-density lipoproteins (HDL) index (5.4±2.0 and 6.6±2.3; p=0.006). Unlike the control group, in which triglyceride levels decreased by 28.4% (p=0.004), very low-density lipoproteins (vLDL) increased by 172.2% (p=0.006), and the ratio of low-density lipoproteins ((LDL)/HDL – by 46.8% (p=0.03)), the study group demonstrated no significant dynamics between the observation points except for a decrease in total cholesterol (10.1%; p=0.03). The levels of triglycerides, vLDL, TC/HDL, LDL/HDL during MI primary hours, and LDL, LDL/HDL, atherogenic index, TC/HDL of the second observation point had an impact on the risk of PH developing in the MI subacute period.

Conclusions. Men under 60 years of age having PH formed in the setting of MI, demonstrated lower levels of the atherogenic index and TC/HDL during the subacute period of MI, as well as the absence of significant dynamics from the first hours to the end of the subacute period of MI of atherogenic fractions of lipid metabolism (triglycerides, vLDL) and their ratios (LDL/HDL). Values of several lipid metabolism components of the MI first hours (triglycerides, vLDL, TC/HDL, LDL/HDL) indicate the high risk of PH developing during the subacute period, which is advisable to use in predictive modelling.

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ABNORMALITIES OF GASTROINTESTINAL MICROBIOCENOSIS INFLUENCING AVERSIVE BEHAVIOUR OF ASD CHILDREN MANIFESTING OR INTENSIFYING

Posted in 2020, Issue № 09(99) September 2020, MEDICINE | 0 comments

It is proved that many manifestations of aversive behaviour are the result of the predominance of intestinal pathogenic microflora of children having autism spectrum disorders. Eradicating the identified bacterial and fungal infections led to a decrease or disappearance of aversive behaviour, and in the case of relapses, it returned. Aversive behaviour occurred due to the neurotransmitter imbalance, neurotoxic action of pathogenic bacteria metabolites, the occurrence of visceral and abdominal pain affected by direct and indirect effects on the vagus nerve and sympathetic trunk of autistic children. Parents and clinicians are recommended to pay attention to the possible gastrointestinal problems when noticing aversive behaviour before resorting to psychotropic medication.

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ADIPOKINES IN RHEUMATOID ARTHRITIS

Posted in 2014, Issue November 2014, MEDICINE | 0 comments

We studied adiponectin and visfatin levels in blood of 55 rheumatoid arthritis patients. We found a relationship between the concentration of adiponectin, visfatin and severity of rheumatoid arthritis.

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DIAGNOSIS AND TREATMENT OF FLOATING PHLEBOTHROMBOSIS OF THE LOWER EXTREMITIES

Posted in 2014, Issue November 2014, MEDICINE | 0 comments

The article is devoted to the diagnosis and surgical prevention of pulmonary embolism in the phlebothrombosis of the lower extremities. It is established that the CBC is an informative method of diagnostics of floating blood clots. Urgent implantation of cava filter, cava or veinplication, crossectomy are effective ways of prevention of pulmonary embolism. After surgery, it is advisable to carry out adequate thrombolytic and antiplatelet therapy for the correction of coagulation disorders, treatment and prevention of progressive phlebothrombosis.

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