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MEDICINE

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ПИ № ФС 77 - 51217

IN VITRO ANTIPROLIFERATIVE POTENTIAL AND ANTIOXIDANT CAPACITY OF NEW COORDINATION COMPOUNDS

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

In the present study the ability of coordination compounds TIA-90, TIA-91 and TIA-93 to induce the inhibition of proliferation in the epithelial cells of pancreatic carcinoma of the BxPc-3 line were investigated. Their cytotoxicity against normal kidney epithelial cells of Madin Darby dog’s MDCK line was also evaluated. The viability of cancer cells was determined by the Alamar Blue test using the redox indicator of resazurin. To identify the antioxidant properties of TIA-90, TIA-91 and TIA-93 anticancer agents, we used a relatively simple but reliable ABTS method. Obtained results showed that the compounds TIA-90 and TIA-93 have greet antiproliferative and antioxidant potentials. The cytotoxic activity of these compounds against normal cells of the MDCK line is lower than that on tumor cells, which indicates the prospect of their use as antitumor agents. However, additional studies are need to evaluate the mechanisms of action of these compounds, as well as their possible adverse effects in other bioassay systems and animal models.

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ASSESSMENT OF THE RISK OF RABIES IN THE NORTHERN REGIONS OF RUSSIA

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

The information on the frequency and incidence of rabies in animals and humans in recent years in the Komi Republic and the Kirov region is presented in the paper. The classification of rabies, the description of strains of rabies virus, features of morphology and reproduction of this microorganism, as well as the pathogenesis and pathological anatomy of this deadly disease are given. The main goal of the study is to warn doctors about the growth of cases of rabies and to provide them the necessary information for diagnosis and treatment of those infected.

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MEDICAL EXPERTISE OF WORKING CAPACITY – A FACTOR OF ADEQUATE OCCUPATIONAL AND SOCIAL RE-ADAPTATION

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

Malignant diseases are an important and topical socially significant problem of the contemporary society.

The present article analyzes the dynamics of the morbidity and disability as a result of malignant neoplasms in different organs in the population of Plovdiv district for a 5-year period – from 2011 to 2015 inclusive. The following facts have been found out:

Morbidity and suffering from malignant neoplasms in the Republic of Bulgaria and more particularly in Plovdiv district have an upward tendency.
The number of registered individuals over 16 years of age in Plovdiv district with permanently reduced working capacity/type and degree of disability in 2015 was 6 050, or 10.6 per one thousand people over 16, compared with 10.8 for Bulgaria.
The relative share of people with disability over 90% is the highest, followed by people with 71-90% disability, 50-70% and those with disability up to 50%.
The most frequent causes of disability are diseases of the blood circulation organs, 34.3% of the total number of registered individuals. They are followed by neoplasms (22.0%), diseases of the eyes and their adjuncts (8.1%), the diseases of the endocrine system and digestion and metabolic disorders (7.6%), diseases of the bone and muscle system and the connective tissues (7.5%), etc.

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METHOD OF STUDYING RHEOLOGICAL PROPERTIES OF MUCIC STOMACH GEL AND ITS DIAGNOSTIC RELEVANCE

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

The paper describes original technique for studying rheological (structural and mechanical) properties of the mucic stomach gel, egested and whole gastric acid by means of centrifugation. It shows high reproducibility of all studied rheological characteristics. Based on the results of the study, it was found that peptic ulcer disease significantly reduced the elastic-viscous properties of gastric mucus for 66 patients and 17 healthy subjects, while the severity and frequency of rheological disorders depend on the localization of the ulcer. It is convincingly proved that rotational viscosity has high diagnostic informativity and can be used to study rheological characteristics of gastric mucus in clinical conditions.

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PROBLEMS OF IMPROVING VOCATIONAL SECONDARY EDUCATION (BASED ON THE RESULTS OF STUDENT SURVEY)

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

The concept of health care and medical science development in the Russian Federation implies an increase of the role of the nursing staff. The quality of education is determined by a set of indicators characterizing various aspects of educational activity of an institution: Content of education, forms and methods of instruction, material and technical base, staff. When planning and improving the educational process, it is necessary to take into account the opinions of its subjects, including students. The conducted sociological survey showed that the structure of the curriculum does not satisfy everyone. 49.2% of students think that the number of hours for practical training should be increased. Most of the students were familiar with the specifics of the nursing profession and made a conscious choice of the future profession.

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ANALYSIS OF TENDENCIES OF POPULATION MORBIDITY OF ARKHANGELSK REGION AS A RESULT OF DISEASES OF BLOOD CIRCULATION SYSTEM AS THE BASIS OF CARDIAC-SURGERY ORGANIZATION

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

The aim of the study was to analyze the main indicators that characterize the population morbidity of the blood circulation system in the Arkhangelsk Region, including those patients who require the diagnosis or treatment with surgical intervention methods against the backdrop of the analysis of similar indicators in the Russian Federation on the whole within ten years. We have determined a significant increase in both general (by 17.8%) and primary morbidity (by 10.9%) among the adult population of the Arkhangelsk region, which significantly exceeded the indicators for the Russian Federation on the whole. We have also defined the growing process of the population’s chronicization with the simultaneous decrease in the death rate of the population from diseases of the blood circulation system by 17.0%.

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ABILITATION OF COGNITIVE DEVELOPMENT, BEHAVIOUR AND SPEECH OF CHILDREN WITH PERINATAL BRAIN INJURY

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

The article contains information on the structurally – functional model of the brain, proposed by AR Luria, the anatomical structures that are part of the three main brain blocks and the functions controlled by them are given. For each structurally functional block the methods of influence and exercise promoting stimulation of work of the brain structures which are a part of this block are given.

This article presents pathogenetic and ontogenetic conditional approaches to programming of habilitation of cognitive and speech functions and behavior for children with perinatal brain injury containing traditional methods of rehabilitation and modern technologies according with classical concepts of integrative brain activity in the framework of structural and functional concept by Lyria A.R. The possibilities of use of the osteopathic correction influencing all blocks of a brain in the organization of the complex medico-correctional help to children are considered.

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EVALUATION OF ANTIOXIDANT MEDICATION INFLUENCE ON PROCESSES OF LIPID PEROXIDATION AND DETERMINATION OF ACTIVITY OF THE SYSTEM OF ANTIOXIDANT PLASMA ENERGY IN THE EXPERIMENT WITH THE USE OF ALLOXAN-INDUCED DIABETES IN COMBINATION WITH HYPERCHOLESTERINEMIA

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

The paper focuses on the effect of antioxidant drugs (mexidol, emoxipin, dimephosfon and a – tocopherol) on patients with alloxan-induced diabetes in combination with the influence of hypercholesterolemia on lipid peroxidation and antioxidant enzymes. Effects of antioxidant drugs influence on lipid peroxidation processes have been studied, as well as pharmacological assessment of antioxidant drug’s effectiveness in the correction of free radical pathology with appropriate interpretation of the data.

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NEW TECHNOLOGIES IN SURGICAL TREATMENT OF PATIENTS WITH CHRONIC SUPPURATIVE OTITIS MEDIA: NAVIGATION SUPPORT

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

The features of navigation support use in the surgery of a temporal bone are given in this paper; they take into account various variations of the anatomy of its bone. The indications for the use of navigation support for the surgical treatment of patients with chronic suppurative otitis media are given. The authors present their experience in the use of the navigation system “Navigation Panel Unit NPU” in addition to the surgery of the temporal bone. The features of preoperative examination of patients with chronic suppurative otitis media and the preoperative planning stage are described; the results of surgical treatment of patients with chronic suppurative otitis media with the use of navigation support are presented in the study.

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POSSIBILITIES OF PULSED OSCILLOMETRY IN DIAGNOSTICS OF A RESTRICTIVE VERSION OF VENTILATION DISORDERS

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

57 patients with idiopathic interstitial pneumonia (IIP) were examined in order to assess pulsed oscillometry (PO) in the diagnosis of restrictive disorders of respiratory mechanics. IIP parameters were compared with spirometry, body plethysmography and the results of the study of elastic properties of the lungs. Patients with IIP had increased resonant frequency (RF) and decreased reactive component of the respiratory impedance (Xrs). The severity of these changes grew as the total lung capacity (TLC) declined while the elastic recoil of the lungs increased. The method can be useful in diagnosing the violations of respiratory mechanics among patients who cannot perform forced respiratory maneuvers.

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NODULAR LESION OF THYROID GLAND, CLINICAL AND MORPHOLOGICAL DIAGNOSIS

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

We have studied 241 cases of thyroid biopsies. The age of the patients varied from 18 to 76 years. The ratio of men and women is 1×13. The majority of non-tumour diseases were made up of goiter. As for tumours, follicular adenoma predominated. Malignant tumours were mostly represented by papillary carcinoma. Morphologically, we have not confirmed the clinical diagnosis of follicular adenoma, which comprised 14.5% of the examined material, while the over-diagnosis of thyroid cancer took place in 2 cases (0.8%). Thyroiditis was not recognized at the clinical stage in 5 cases, which comprised 50% of the inflammatory lesions of the organ based on our material. Cancer was diagnosed morphologically in case of 9 patients (3.7%). 14 patients were diagnosed with follicular adenoma (5.8%). The causes of clinical and morphological discrepancies are mostly objective.

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NAFLD AS A MODEL OF A PATIENT WITH HIGH CARDIOVASCULAR RISK

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

The article presents the results of the study of the state of the cardiovascular system of patients with non-alcoholic fatty liver disease (NAFLD). It shown the high prevalence of cardiovascular risk factors among persons with NAFLD, leading from which were dyslipidemia, arterial hypertension, overweight, and insufficient physical activity. According to the PROCAM scale, in 26% of patients the risk of acute coronary heart disease in 10 years was 65%, in 55% the likelihood of fatal outcome due to cardiovascular disease (SCORE scale) was also high. It studied chronobiological indicators of the cardiovascular system in patients.

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PREDICTORS OF UNFAVORABLE OUTCOMES OF MYOCARDIAL INFRACTION IN MEN YOUNGER THAN 60 YEARS IN THE NORTH-WEST REGION OF THE RUSSIAN FEDERATION IN DIFFERENT SEASONS OF THE YEAR

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

The effect of the complex of seasonal factors and regional features on the outcome of myocardial infarction has not been adequately studied and is not taken into account in practical work. The study showed that the likelihood of an unfavorable outcome in myocardial infarction in men younger than 60 years throughout the year does not change significantly, but its predictors in different seasons are not uniform. The proposed mechanisms underlying these changes are estimated. The information obtained allows one to change the approaches to the prevention of complications of the disease, the rationale and choice of treatment tactics by influencing potentially corrected factors, taking into account seasonal peculiarities of the North-West region of the Russian Federation.

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THE USE OF FGP-PLASTIC FOR TELESCOPIC CROWNS OF REMOVABLE DENTURES WITH SUPPORT ON IMPLANTS

Posted in 2017, Issue № 5(59) May 2017, MEDICINE | 0 comments

The article presents clinical experience of using FGP-plastics for telescopic crowns of overdenture restoration supported by dental implants. Telescopic crowns are used in clinic and orthopedic dentistry to fix overdenture restoration supported by dental implants. In order to perform the analysis we conducted orthopedic treatment of patients, 9 men and 12 women, aged 45-60 years. Orthopedic treatment of patients was carried out on the basis of oral surgery, dentistry and orthopedic dentistry departments of the FSBEI of Higher Education “Samara State Medical University” of the Ministry of Health of Russia. Usage of FGP-plastic system for fixation and accurate fitting of telescopic crowns enabled us to increase the fixation strength of overdenture restorations support by dental implants.

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CHANGE OF INDICATORS OF THE oral fluid IN WOMEN OF REPRODUCTIVE AGE IN DIFFERENT PHASES OF THE MENSTRUAL CYCLE

Posted in 2017, Issue № 4(58) April 2017, MEDICINE | 0 comments

The article presents the results of the study of gonadotropic and steroid hormones, immunological parameters of the oral fluid, as well as some physicochemical properties of saliva in different phases of the menstrual cycle in women of reproductive age. Their dependence on the phase of the menstrual cycle was revealed. The obtained data allow correctly interpret the changes in these parameters for various diseases of the teeth-jaw system, evaluate the effectiveness of the treatment and choose the optimal timing for planning surgical interventions in the tissues of the oral cavity and maxillofacial area.

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COMPLAINTS OF CITIZENS ON VIOLATION OF THEIR RIGHTS AT HEALTHCARE DELIVERY

Posted in 2017, Issue № 4(58) April 2017, MEDICINE | 0 comments

The paper presents the results of the analysis of complaints from the citizens of the Republic of Bashkortostan concerning the healthcare delivery. The analysis of complaints of citizens for the studied period from 2013 to 2015 showed the increase in their number by a factor of 1.5. The majority of citizens’ complaints were filed in the form of applications, and less – in the form of complaints and proposals. The complaints of citizens were studied depending on the source of receipt, the applying person and the method of application. As a result it was found that in most cases, complaints were applied and sent by other persons (relatives, neighbors, etc.), the citizens themselves addressed only in 35-37% of cases. The analysis of citizens’ complaints showed that during the period under review the greatest number of complaints in 2013 was received in February and April, in 2014-2015 in April and December. The majority of complaints (19.3-22.3%) were received by the Ministry of Health of the Russian Federation. Among the citizens who applied complaints, the majority were non-working persons. Complaints of citizens were mostly sent by e-mail.

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CONTINUING MEDICAL EDUCATION: THE NEED FOR CHANGE

Posted in 2017, Issue № 4(58) April 2017, MEDICINE | 0 comments

Introduction: the article considers the problem of continuing medical education (CME) formation in today’s changing environment, identifies characteristics and functioning of CME mechanisms. The purpose of the article is the identification and study of the most topical issues in the field of CME for their systematization and further changes of the existing process of medical training.

Materials and Methods: the methodology of the study is a comprehensive analysis of CME problems, its orientation and contents at different levels of the modern educational system, which allows exploring CME primarily as the continuous improvement of professional skills.

Results of the study: the authors of the article have considered the questions and problems of CME in the Russian Federation (RF), stressed the importance of the state health development programs for refresher training and retraining of doctors. It is noted that in the foreign research literature considerable attention is also paid to a variety of approaches to the definition of concepts in the field of CME: “education throughout life”, “the process of acquiring new knowledge and skills.” Based on the analysis of the study data the significance of CME in the development of the socio-economic system of RF is determined.

Discussion and conclusion: at the end of the article the authors of the study make conclusions that reveal the specifics of the ongoing changes reflected in CME functioning. The authors emphasize that a modern medical professional must constantly maintain and improve their knowledge.

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INFLUENCE OF PROTEIN MEALS AND GAINER ON THE URINARY SYSTEM OF RATS

Posted in 2017, Issue № 4(58) April 2017, MEDICINE | 0 comments

The influence of protein meals and gainer on the urinary system of rats was studied in the paper. Macroscopic and microscopic studies of the animals’ kidneys were carried out. Biochemical indices of the urine of the animals under study under laboratory conditions were analysed. After the intake of protein meals and gainer we detected pathological changes in the structure of kidneys among rats in the course of three months. The objectives of the article are to raise the problem of the negative effect of protein meals on the urinary system, to distribute data on the results obtained and to prevent harmful effects of protein meals on the urinary system.

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GENDER CHANGES IN MORBIDITY RATE OF BENIGN HORMONE-DEPENDENT TUMORS IN THE FIRST HALF OF THE 21ST CENTURY

Posted in 2017, Issue № 4(58) April 2017, MEDICINE | 0 comments

The paper considers the current problem of bening hormone-dependent tumors. It presents the characteristics of the most frequently occurring hormone-dependent tumors, such as benign prostatic hyperplasia and uterine myoma. The study of morbidity rate of myoma in the Kirov region was carried out. The evidences of increasing in cases of prostatic adenoma are shown in the paper as well. The materials information was taken from: operational journals, statistical reports, reference materials for gynecological and urological services. The pathologies concerned proved to be rejuvenated.

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INDIVIDUALIZATION OF DIET FOR PATIENTS WITH SKIN DISEASES

Posted in 2017, Issue № 4(58) April 2017, MEDICINE | 0 comments

The condition of integuments of the person as the business card of health of all organism, reflects both a disadvantage of a dream, and nervous experiences, and errors of the alimentary status, including, problems with an intestine. Inhabiting beneficial microorganisms are an indispensable aid gastrointestinal tract: absorption of nutrients and vitamins that cleanse the body of toxins, promote the normal functioning. Therefore, if the skin condition distresses us, the first place it is necessary to pay attention to the intestine. Today the interrelation between a condition of intestinal microflora and development of a psoriasiss ̶ a serious autoimmune illness is proved. In spite of the fact that scientists didn’t come to a consensus about the causes of a psoriasis yet, influence of the balance of intestinal microflora on a skin doesn’t raise doubts. First of all along with medication to restore the intestinal flora, it is necessary to normalize the diet, to include prebiotics, probiotics and bacteriophages. For regular replenishment of the body’s beneficial bacteria should be consumed as fermented milk and fermented products. This list must include: fermented baked milk and yogurt, cheese, sauerkraut, pickled apples, onion and etc.

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