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MEDICINE

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ПИ № ФС 77 - 51217

CASE OF COMPRESSION ASPHYXIA

Posted in 2017, Issue № 9(63) September 2017, MEDICINE | 0 comments

The practice of forensic medicine is extensive. Compression mechanical is quite rare. The compression of the chest and abdomen as a kind of mechanical asphyxia occurs in those cases when the compression of the trunk does not lead to multiple injuries, such as fractures of bones and ruptures of internal organs. The article cites the case of mechanical asphyxia due to the compression of the chest and abdomen between the moving parts of the lift. In the course of the study, morphological signs were revealed – they enable the differentiation of this type of death from deaths resulting from blunt traumas.

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CHARACTERISTIC OF THE WAY OF LIFE AND WORKING CONDITIONS OF DOCTORS OF FUNCTIONAL DIAGNOSTICS

Posted in 2017, Issue № 9(63) September 2017, MEDICINE | 0 comments

A study of 104 doctors of functional diagnostics of the Udmurt Republic was conducted. The data were obtained with the help of a specially developed questionnaire. The survey was conducted with the informed consent of respondents and with the observance of ethical norms. Our study shows that doctors of functional diagnostics have a low level of health-saving and self-protective behavior. Obtained results are necessary to develop preventive measures to improve the health of doctors and reduce labour losses.

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SIGNS OF ACUTE MYOCARDIAL ISCHEMIA IN PATIENTS WITH ACUTE PREMATURE FIBRILLATION IN THE PROGNOSTICATION OF CORONARY ATHEROSCLEROSIS

Posted in 2017, Issue № 9(63) September 2017, MEDICINE | 0 comments

The results of examination of 77 patients of the emergency cardiology department with a working diagnosis of acute coronary syndrome without ST segment elevation in the background against the background of acute atrial fibrillation (less than 48 hours old) are presented. Coronary heart disease was corroborated by coronary angiography. The cumulative incidence and diagnostic efficacy of signs of myocardial ischemia (anginal pain, increased troponin T, ECG changes) in the prediction of coronary artery atherosclerosis in this group of patients was estimated. The most sensitive were chest pain (77%) and ECG changes in atrial fibrillation (63%), the most specific were an increase in the level of troponin T (87%) and the changes (81%) remaining on the sine rhythm of the ECG, the highest index of diagnostic efficiency was found in the increase in the level of troponin T (66%).

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MODEL OF FORECASTING THE DEVELOPMENT OF GASTROINTESTINAL BLEEDING AGAINST THE BACKGROUND OF STRESS ULCER AMONG PATIENTS WITH MATTERY SURGICAL PATHOLOGY

Posted in 2017, Issue № 9(63) September 2017, MEDICINE | 0 comments

Forecasting of the development of pathology and timely prevention of the corresponding complications is a promising direction of medical science at the present time. Gastrointestinal bleeding developed against the background of acute erosive-ulcerative lesions is a life-threatening condition, aggravating the prognosis of the course of any disease. Employees of the SamSMU Clinics identified risk factors and developed a model for predicting the development of gastrointestinal bleeding against the background of acute ulcers of the upper gastrointestinal tract among patients with mattery surgical pathology. Expert evaluation showed a high quality of the forecast of the proposed model – 87.3%, which allows recommending it for the use among profile patients.

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MORPHOMETRIC DETERMINATION OF GENDER DIFFERENCES IN HUMAN PHYSIQUE AMONG PERSONS OF FORTY YEARS OF AGE

Posted in 2017, Issue № 9(63) September 2017, MEDICINE | 0 comments

The aim of the article is to study the triad of morphometric indices among persons of forty years of age and their gender differences. Morphometric examination of 50 men and 132 women was carried out; body mass index (BMI), body physique index (BBI), fatness index (FI) were studied. Gender differences in the physique are of a highly reliable character – more detailed analysis of body types allowed to isolate normally, excessively and insufficiently fed asthenics (AS), normostenics (NS) and hypersthenics (HS), as well as well-fed semi-AS and semi-HS (11 variants in total). The proposed classification of types of physique is of undoubted practical importance.

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ECONOMIC EFFICIENCY OF KIDNEY TRANSPLANTATION IN COMPARISON WITH HEMODIALYSIS PROGRAM AMONG PATIENTS WITH TERMINAL STAGE OF CHRONIC RENAL INSUFFICIENCY

Posted in 2017, Issue № 9(63) September 2017, MEDICINE | 0 comments

The following article considers the main causes of chronic renal failure, as well as the main methods of its treatment at the terminal stage, namely hemodialysis and kidney transplantation. The structure and cost of each of these methods are considered, the economic efficiency of kidney transplantation is compared with hemodialysis. Comparative characteristics of the methods are given by the criterion of the quality of life of patients using the QALY index. The analysis concluded that transplantation is the leading method for treating the terminal stage of chronic renal failure while hemodialysis should be used as a reserve method. This article contains up-to-date information and can be useful to health managers, practicing doctors, medical residents and students.

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THERAPEUTIC PREVENTIVE MEASURES OF DIABETIC RETINOPATHY

Posted in 2017, Issue № 8(62) August 2017, MEDICINE | 0 comments

We have discovered a positive effect of the use of magnesium orotate, a drug of magnerot, on the state of veins of the eye fundus of patients with hyperlipidemia combined with diabetic retinopathy with type 1 and 2 diabetes. There were signs of improvement in the microcirculation of the fundus. There was a decrease in the level of glucose, glycosylated hemoglobin, and total cholesterol against the background of taking the drug. A slight increase in the magnesium level was found in the study group of patients. The possibility of using magnesium orotate, a drug of magnerot, as a curative preventive measure of diabetic retinopathy of patients with hyperlipidemia was analyzed.

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COGNITIVE PSYCHOMETRIC INDICES OF PATIENTS WITH PRIMARY HYPOTHIROSIS BEFORE AND AFTER TREATMENT

Posted in 2017, Issue № 8(62) August 2017, MEDICINE | 0 comments

The article reviews information on cognitive disorders in cases of primary hypothyroidism. We examined 36 women aged 45-65 years old with primary hypothyroidism during decompensation (at admission) and 10 days after the treatment with levothyroxine sodium in the hospital. We made analysis and conducted comparative evaluation of the results of psychometric scales assessing cognitive disorders before and after the treatment of patients with primary hypothyroidism in the hospital. Recommendations on practical public health and the introduction of regular monitoring of cognitive functions of these patients are formulated.

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DECREASE OF TRANSAMINASE ACTIVITY BY THE TOTAL EXTRACT OF PHYTOCOMPOSIS IN CASES OF LIVER TOXIC DAMAGE

Posted in 2017, Issue № 8(62) August 2017, MEDICINE | 0 comments

The aim of this study is to conduct the correction of the amount of extracts of Phytocomposition No.1+Phyto F (Ph No.1+Phyto F) with increased activity of transaminases, indicating necrotic changes in the liver with the release of enzymes into the bloodstream under the conditions of toxic hepatitis. Ph No.1+Phyto F was administered per os daily for 10 and 20 days after the reproduction of the pathology. At the same time, a series of treatments with Essentiale Forte N (EFN) was carried out for comparison. In the control series, the animals in all samples showed an increase in the activity of liver enzymes, confirming the development of cytolysis syndrome. After the treatment courses, the activity of serum enzymes was investigated: Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP), lactate dehydrogenase (LDG), gamma-glutamyltransferase (γ-GT).

Results. The effect of the phytocomposition caused a significant decrease in the activity of enzymes and the enzyme of the hepatobiliary system – alkaline phosphatase. The deflection from control coefficient of liver enzymes activity indices indicates a decrease in hepatocyte damage, as well as the effectiveness of PhNo.1+PhytoF. The results of comparative analyzes, during treatment also showed significant efficiency of the Phytocomposition No.1+Phyto F. Phosphorometric spectrophotometry was used to determine the qualitative composition of Ph No.1+Phyto F [4]. The coincidence of the absorption maxima of the working and standard solutions was found, which indicates possible presence of essential phospholipids in the Ph No.1+Phyto F tested. The use of Ph No.1+Phyto F prevents the formation of hyperfermentation with almost complete recovery of the studied indicator at the end of the third week of observation. Based on the results of the analysis of cessation values, the calculation of coefficient of hepatoprotective activity also confirms that Ph No.1+Phyto F has hepatoprotective activity.

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TACTICS OF ENDOVASCULAR TREATMENT OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH ST-SEGMENT ELEVATION, EFFECT OF THROMBUS ASPIRATION ON THE EFFECTIVENESS OF TREATMENT

Posted in 2017, Issue № 8(62) August 2017, MEDICINE | 0 comments

The aim of the study was to consider the effect of trombus aspiration procedure when combined with stenting and angioplasty when treating patients with acute myocardial infarction with ST segment elevation. After conducting subsequent endovascular treatment for infarction of the responsible artery, we observed full recovery of epicardial blood flow and myocardial impregnation in groups with thromboextraction more often, compared to the group with standard endovascular treatment. It has been established that a properly performed thrombus aspiration procedure reduces the frequency of distal embolization and reduces the frequency of dislocation of thrombotic masses.

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PREHOSPITAL THROMBOLYSIS OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH ST-SEGMENT ELEVATION IN COMBINATION WITH URGENT ANGIOPLASTY AND THROMBUS ASPIRATION

Posted in 2017, Issue № 8(62) August 2017, MEDICINE | 0 comments

In cases of drug and endovascular myocardial reperfusion the risk of complications decreases due to the reduction of load on infarct related artery. No serious complications such as cerebral circulation and myocardial embologenic were detected among patients with acute myocardial infarction with ST segment elevation in the group with formed thrombus aspiration. As for a group with prehospital thrombolysis, there were no deaths in it, indicating the effectiveness of thrombolysis as a preventive measure.

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CENTRAL HEMODYNAMICS, THYROID STATUS AND DYSFUNCTIONS OF ENDOTHELIA IN PATIENTS WITH ARTERIAL HYPERTENSION IN HIGHER TREATMENT

Posted in 2017, Issue № 8(62) August 2017, MEDICINE | 0 comments

The paper presents data on the parameters of central and intracardial hemodynamics, the structural and functional state of the left ventricle (LV) and the influence of the thyroid-stimulating hormone (TSH), thyroid hormones (TH) -triodothyronine T3, thyroxine T4 and metabolites of nitrogen oxide (NO) – nitrites (NO-2) and nitrates (NO-3) on them. It has been found that a decrease in the production with a simultaneous decrease in the thyroid hormone concentration causes disturbances in intracardial hemodynamics, changes in the structural and functional state of LV, and increase the course of arterial hypertension. With the help of the multiple regression equations, the regularities reflect the dependence of the absolute and relative values of hemodynamic parameters and LV structural and functional status on the concentration of thyroid hormones and NO in the blood.

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DIFFERENTIAL DIAGNOSTICS OF NEUROLOGICAL DEFICIENCY IN CASE OF HYPOTHYROIDISM

Posted in 2017, Issue № 8(62) August 2017, MEDICINE | 0 comments

Hypothyroidism occupies the leading place among all endocrinological diseases from the point of view of frequency. Failure in the thyroid gland work inevitably affects all body systems, which, as a rule, leads to polymorphic symptoms that can be taken for other diseases. Therefore, in this article we considered all possible manifestations of the disease, including its “masks,” which is of great practical importance for doctors of many profiles. The work is of an interdisciplinary nature, but is written at the junction of endocrinology and neurology. The authors attempted to look at hypothyroidism from the neurologist’s perspective and proved the relevance and significance of identifying this syndrome in a neurological study. The article collected and described the main neurological disorders associated with hypothyroidism and namely hypothyroid myopathy, myopathic phenomenon, cranial and peripheral nerve damage, encephalopathy. Particular attention is paid to all known and currently used methods for diagnosing hypothyroidism, because correct and timely diagnosis allows avoiding lengthy diagnostics and eliminating pathology in other body systems in the polymorphic course of the disease which has great practical and economic significance.

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MORPHOLOGICAL CHARACTERISTICS OF ISCHEMIZING EXPERIMENTAL WAIST HEALING ON THE 12TH DAY AFTER AUTO- AND HETEROFIBROBLASTS AND DERMAL EQUIVALENT USE

Posted in 2017, Issue № 8(62) August 2017, MEDICINE | 0 comments

The study was performed on 28 1-year-old white mature mice of the C57/B1 line. 0.4 ml of fibroblast suspension and dermal equivalent in the growth medium DMEM F12 (Lonza) in an amount of 1.33 million cells were injected into and around the bottom of the surgical model skin wound in the scapular region. The scar was poured into paraffin, stained with hematoxylin and eosin. On the 12th day the epidermis is thicker after administration of auto-fibroblasts but more differentiated after transplantation with dermal equivalent with heterofibroblasts. Angiogenesis and collagenogenesis are more actively stimulated by auto-fibroblasts. Regenerative histogenesis comparatively identical proceeds against the background of the presence of autofibroblasts and a dermal equivalent with heterobifroblasts.

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MORPHOMETRIC DETERMINATION OF GENDER DIFFERENCES IN THE BODY TYPE OF TWENTY-YEAR-OLD PERSONS

Posted in 2017, Issue № 8(62) August 2017, MEDICINE | 0 comments

The study of morphometric indices in twenty-year-old people, their gender differences, the identification of options for combining fatness and body type was conducted. Morphometric examination was performed in 128 men and 177 women aged from 18 to 22 years; the body mass index (BMI), body build index (BBI), fatness index (FI) were studied. Gender differences in body type in a group of normally well-fed normosthenic people are easily identifiable and highly reliable. With the help of BMI2, BBI and FI, all body types (asthenic, normosthenic and hypersthenic) can be divided into normal, overweight or not enough well-fattened variants with simultaneous detection of 2 intermediate variants (normally well-fed semi-asthenic and normally well-fed semi-hypersthenics). Practical application of the results can be found in the clinic of internal diseases.

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MEASUREMENT OF EXHALED AIR TEMPERATURE AMONG ATHLETES WITH BRONCHIAL ASTHMA

Posted in 2017, Issue № 8(62) August 2017, MEDICINE | 0 comments

The article considers the analysis of the innovative method of early diagnosis and control over the course of bronchial asthma – the measurement of the exhaled air temperature. The temperature of the exhaled air was evaluated among healthy athletes and athletes with bronchial asthma before and after physical exercises. It was found that running causes a significant increase in the temperature of the exhaled air, but this increase is not significantly different among healthy runners and patients with controlled asthma.

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PROTECTION OF INTERESTS OF MEDICAL WORKERS IN CONSIDERATION OF ISSUES ABOUT NON-DELICIOUS PROVISION OF OBSTETRIC AND GYNECOLOGICAL ASSISTANCE (LITERATURE REVIEW)

Posted in 2017, Issue № 8(62) August 2017, MEDICINE | 0 comments

The article gives an overview of contemporary, mostly domestic literature on defects in the provision of obstetric and gynecological care. Without denying the reality of the problem of poor quality medical care, a number of authors note the increase in manifestations of “consumer extremism” among patients and their relatives aimed at obtaining unreasonable material benefits at the expense of medical and preventive institutions and medical workers. Medical activity also attracts increased attention of controlling bodies, mass media, various public organizations. As a result, scientists testify to the emergence of the phenomenon of “defensive medicine”, which means that doctors preferring methods of diagnosis and treatment based on the principle of minimizing the likelihood of potential risks, rather than effectiveness, appropriateness and sufficiency. Most authors associate defects in the provision of medical, including obstetric and gynecological care, with medical errors based on a conscientious delusion, for which the doctor should not be held criminally liable. The literature indicates the need to insure the liability of doctors and medical organizations and the reasons why such insurance has not become a universal phenomenon.

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EVALUATION OF FUNCTIONAL RESTORATION OF PATIENTS AFTER ISCHEMIC TYPE ACUTE DISORDER OF CEREBRAL CIRCULATION

Posted in 2017, Issue № 8(62) August 2017, MEDICINE | 0 comments

One of the main tasks of practical health care and neurological service in particular is to reduce the prevalence of cerebrovascular disease, and in the case of stroke – to render high-tech specialized medical care timely and effective. All patients with stroke should receive specialized medical care as soon as possible, as well as undergo all the necessary follow-up rehabilitation measures. All this will reduce the mortality and morbidity rates of acute cerebrovascular accidents.

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INDUCTION OF APOPTOSIS IN CUTANEOUS MELANOMA CELLS BY CATIONIC PEPTIDES

Posted in 2017, Issue № 7(61) July 2017, MEDICINE | 0 comments

Cutaneous melanoma (CM) is an aggressive oncological disease with early growth of metastasis. Disseminated MK is resistant to most chemotherapeutic agents with letality in ~ 30% of cases. Molecular-directed therapy allows to solve this problem. Chaperone proteins nucleolin / NCL and nucleophosmin / NPM, which form about 70% of the nucleolus volume, are considered as promising targets for targeted therapy. These proteins are overexpressed in tumor cells. It was first proposed to use cationic peptides – a possible ligands for receptor NCL – for the induction of apoptosis in cutaneous melanoma cell cultures.

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USING CORRELATION ANALYSIS TO PROVE THE EFFICIENCY OF INTRODUCTION OF FORMULARY LIST FOR ANTIMICROBIAL MEANS IN A HOSPITAL

Posted in 2017, Issue № 7(61) July 2017, MEDICINE | 0 comments

Antimicrobial agents are the most expensive item in the budget of multidisciplinary medical institutions operating as emergency medical care centers. The standardization in health care involves the development of formulary lists and treatment guidelines. The filling of a formulary list with specific names of antimicrobial agents depends on the potential effectiveness of those with respect to the most significant pathogens of nosocomial infections. If the formulary list contains validated antibiotics, it inevitably leads to the improvement in the quality of the work at the hospital, and that can be proved by carrying out a correlation analysis.

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