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PHARMACEUTICS

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ПИ № ФС 77 - 51217

DISTRIBUTION OF ALPHA-[3-[[2-(3.4-DIMETHOXYPHENYL)-ETHYL]-METHYLAMINO] PROPYL]-3.4-DIMETOXY-ALPHA-(1-METHYL-ETHYL) BENZOL ETHAN NITRILE IN THE ORGANISM OF WARM-BLOODED ANIMALS

Posted in 2017, Issue № 6(60) June 2017, PHARMACEUTICS | 0 comments

The article studies the distribution of alpha-[3-[[2-(3.4-dimethoxyphenyl)ethyl]-methylamino] propyl] -3.4-dimethoxy-alpha-(1-methylethyl) benzol ethan nitrile in the organism of omnivorous warm-blooded animals (rats) after intragastric infiltration of a half lethal dose of the poison agent. Isolation of alpha-[3-[[2-(3.4-dimethoxyphenyl)ethyl]-methyl-amino] propyl]-3.4-dimethoxy-alpha-(1-methylethyl) benzol ethan nitrile from organs, their contents and bio-fluids of the animals was conducted with the help of acetone. Purification of the extracted compound was carried out by chromatography on a column of “Silasorb S-18” 30 micrometers (eluent-ethan nitrile-water (9:1)). To identify and quantify the test compound, TLC, GC-MS, and UV spectro-photometry were used. The presence of the largest quantities of the tested substance is fixed in the stomach, its contents, liver and kidneys. The results obtained enable us to recommend these organs as the main objects of forensic and chemical analysis for finoptin poisoning.

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STANDARDIZATION OF “IBUPROSOL” GEL WITH APPLICATION OF ALKALIMETRIC METHOD

Posted in 2017, Issue № 6(60) June 2017, PHARMACEUTICS | 0 comments

The article offers a new soft preparation form of “Ibuprozol” based on the “Tizol” gel and containing 3.0% of ibuprofen. The ionization constant of the preparation in the water-ethanol medium was established, the curve of alkalimetric titration was calculated and drawn, and indicators were selected. A simple and reproducible method for the quantitative analysis of ibuprofen in ointments was developed. It enables us to determine the content of a pharmacologically active substance with an error within the limits of permissible norms and deviations provided for by normative and technical documentation.

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VALIDATION OF QUANTITATIVE DETERMINATION METHOD OF CHLOROXEXIDINE BIGLUCONATE IN GEL FOR DENTINE CARIES TREATMENT

Posted in 2017, Issue № 4(58) April 2017, PHARMACEUTICS | 0 comments

The paper presents the results of validation method for quantitative determination of chlorhexidine bigluconate in gel for dentine caries treatment. Lauryl-sulfate method was proposed as a means of quantitative determination of chlorhexidine bigluconate according to precipitation titration variant. The method was evaluated by validation characteristics: Analytical field of application, linearity, accuracy and precision (convergence). As a result of the conducted studies, it was found that analytical range of application of the proposed method from 80 to 120% confirmed the linear dependence of titrant consumption on the quantitative content of chlorhexidine bigluconate, the average regeneration rate comprised 99.2%. The validated procedure allows determining quantitative content of chlorhexidine bigluconate in the presence of concomitant components and can be recommended for inclusion in regulatory documentation.

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MARKETING RESEARCH OF RUSSIAN AND REGIONAL MARKET OF MEDICINAL DRUGS APPLIED FOR TREATMENT OF ACUTE INTESTINAL INFECTIONS

Posted in 2017, Issue № 4(58) April 2017, PHARMACEUTICS | 0 comments

Acute intestinal infection (AII) is one of the most significant problems of medicine and public health in general, due to the global presence and no tendency in reduction of incidence. In order to determine meeting of the need for medicines, children suffering from acute intestinal infections, the target segment of the Russian and regional pharmaceutical market (Republic of North Ossetia-Alania) and the drugs used to treat AII, were investigated. Using the marketing analysis methods, the assortment of drugs used for the treatment of acute intestinal infections of various etiologies was studied and systematized, the saturation of the regional market compared with the all-Russian one is given as well.

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THE COMPARATIVE ANALYSIS OF DOPAMINERGIC DRUGS, WHICH USED FOR A MEDICAL TREATMENT OF PARKINSON’S DISEASE AND WHICH INCLUDED INTO FEDERAL GUIDELINES FOR THE USE OF THERAPEUTIC AGENTS OF THE RUSSIAN FEDERATION

Posted in 2016, Issue November 2016, PHARMACEUTICS | 0 comments

The article states the comparative analysis of dopaminergic drugs, which used for a medical treatment of Parkinson’s disease and which included into Federal guidelines for the use of therapeutic agents of the Russian Federation. During the research we have analysed the section “Drugs for Parkinson’s disease treatment” in Federal guidelines for the use of therapeutic agents of the Russian Federation published in 2010, 2013, 2016. The comparative analysis of the dopaminergic drugs revealed that in the list of agents for medical treatment of this disease there are some changes and additions every year. It is found that in the latest editions of Federal guidelines additional tradenames of therapeutic agents with more accessible forms of issuance and dosage are provided, what improves the quality of medical treatment of Parkinson’s disease and also produces a necessary degree of comfort in a usage of a medicament or in a correction of a dose.

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THE ROLE OF CERULOPLASMININ THE Α2- GLOBULIN FRACTION OF PROTEIN METABOLISM IN THE LIVER INDUCED BY CARBON TETRACHLORIDE AND ITS CORRECTION BY PHYTOCOMPOSITION №1 + PHYTOF 

Posted in 2016, Issue August 2016, PHARMACEUTICS | 0 comments

The pharmacological effect of the total extract of Phyto composition №1 + PhytoF (F№1 + PhytoF) on the functional state of hepatocytes, namely the metabolism of proteins, in comparison with the classical hepatoprotectorEssentiale forte N (EFN) and extract of Paliurusspina-christi (PSCh), which is in the composition of (F№1 + PhytoF), was studied in rabbits with liver induced by carbon tetrachloride. To this end,the complete analysis of total protein, albumin, globulin, and ceruloplasmin (CP), which is in the composition of the α2-globulin fraction as one of the main components of the antioxidant defense system and the response of the organism to stress factors, was performedand the protein coefficient was determined. The research showed thatamong the investigated proteinsin allgroups of studied animals, the pharmacological activity of F№1+PhytoF had the greatest effect on the synthesis of CP and globulin fraction content. Further, in a comparative aspect, the coefficient of variation from controls (CV) for (F№1 + F), (EPN), (PSCh) was determined by (CP),and based on the data of the changes of the protein fractions, hepatoprotective activity of the studied compounds was established.

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COMPARATIVE ANALYSIS OF THERMAL WATER USED FOR THE CARE OF SKIN

Posted in 2016, Issue August 2016, PHARMACEUTICS | 0 comments

In article the concept of thermal waters, which are extracted from underground sources and their temperature is always above ambient, and fits most 30°C. as the classification of thermal waters, used for the care of the skin depending on salinity and Ph, the comparative analysis of ion composition of the thermal water production in France and Russia. Determined the effect of these thermal waters on the skin which with constant use softens skin, possesses anti-inflammatory properties and accelerates skin regeneration.

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MORPHOLOGICAL AND ANATOMICAL DIAGNOSTIC FEATURES FEVERWEED CAUCASIAN AND ERYNGIUM PLANUM

Posted in 2016, Issue July 2016, PHARMACEUTICS | 0 comments

Studied the microstructure of roots, stems and leaves of Eryngium planum and feverweed Caucasus in order to establish diagnostic features and secretory structures. The obtained results allow to identify plant material and can be used in the development of a regulatory document under the heading “Microscopy”. Essential oil tubules found in the roots, stems, petioles and leaf blades. They are located in the roots in the phloem and pericyclic zone, accompanied by vascular bundles in the aboveground organs. Branching stem in inflorescence false – dichotomy. Leaf blade dorsoventral type amfistomaticheskaya.

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COMPETITIVENESS NETWORK PHARMACY IN VELIKY NOVGOROD

Posted in 2016, Issue June 2016, PHARMACEUTICS | 0 comments

In market conditions the competitiveness of the organization is one of the important tasks of modern pharmacy. This index is examined on pharmacy chains in Veliky Novgorod. In our study, the concordance coefficient is 0.58, it indicates the consensus of expert opinions. They chose the location of pharmacy, its assortment of goods, staff qualification and the level of prices as the most important factors of the competitiveness. Based on expert opinions and survey of visitors in network pharmacies integral competitiveness index ranged from 0.915 to 0.949, it demonstrates that all three network pharmacies are sufficiently strong competitors. However, the calculation of each parameter of competitiveness from the viewpoint of buyers identified capabilities to improve the work of pharmacies.

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EFFECT OF DIFFERENT SIZED ZINC COMPOUNDS ON THE LIFTING FORCE OF THE TEST CULTURE SACCHAROMYCES CEREVISIAE

Posted in 2016, Issue May 2016, PHARMACEUTICS | 0 comments

The article presented a study of the effects of inorganic Zn compounds of various size and morphology (technical samples ZnO, Zn(OH)2 and ZnSO4, micronized by different ways ZnO samples and synthesized nanoscaled Zn(OH)2) to the lifting force of the test culture of Saccharomyces cerevisiae. High activity of slightly soluble connections when comparing with an ionic form is shown. Dependence of a biological response on morphology and dimension of the studied connections is observed.

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ANALYSIS OF THE USE OF ANTIFUNGAL MEDICATIONS AT THE STAGE OF A COURSE OF TREATMENT AND DEFINITION OF VALUATION THE TREATMENT OF PATIENTS WITH FUNGAL LESIONS OF THE SKIN AND NAILS

Posted in 2016, Issue May 2016, PHARMACEUTICS | 0 comments

The treatment of fungal diseases is a rather complicated process, requiring the use of fungicidal and fungistaticescoe drugs. It is known that the effectiveness of traditional treatment regimens is low. The use of modern antifungal drugs improves the effectiveness of therapy of fungal diseases. Analyzes the use of antifungal drugs in various dosage forms for the treatment of fungal infections of the skin and nails.

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THE SEARCH DEPENDENCE OF HYPOGLYCEMIC ACTIVITY FROM THE IONIZATION CONSTANTS IN THE SERIES OF N’–ACYLHYDRAZIDES OF N–ACYL–5–BROMO(5–IODO)ANTHRANILIC ACIDS

Posted in 2016, Issue May 2016, PHARMACEUTICS | 0 comments

The values of ionization constants (pKa and pKв) of 6 substances of N’-acylhydrazides of N-acyl-5-bromo(5-iodo)anthranilic acids by method of potential semi-neutralization are experimentally defined. It is transacted the analysis of regression and received 6 correlation equations connecting the pKa and pKв with experimentally defined hypoglycemic activity (HGAexp.). Values of HGA action with use of the made equations are calculated. It is experimentally defined HGAexp. of investigated 2 substances which by results of biological tests are active. To assess the HGA prediction compared with HGAexp., computed confidence interval of the individual prediction.

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VIOLATIONS OF ERYTHROCYTES MEMBRANES FATTY ACIDS PATTERN AT THE NITROGEN OXIDES INTOXICATION AND THEIR PREVENTION BY PLANT EXTRACTS

Posted in 2016, Issue April 2016, PHARMACEUTICS | 0 comments

Pilot studies on studying of preventive introduction of the «Kalifen» extractemitted from a guelder-rose (Viburnum sargentii Koechne) and extract of an eleuterokokk to intoxication with nitrogen oxides are conducted. It was shown that intoxication nitrogen oxides was followed by violation in the ratio of fatty acids in a membrane of erythrocytes: the amount of saturated fatty acids increased and the amount of nonsaturated fatty acids decreased. Preliminary introduction of a kalifen to intoxication nitrogen oxides in a greater degree possessed protective effect on the fatty acids in erythrocyte membranes, than that at introduction extract eleuterococcus.

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DEVELOPMENT OF GOOD PRACTICE FOR HANDLING OF BIOMEDICAL CELL PRODUCTS

Posted in 2016, Issue April 2016, PHARMACEUTICS | 0 comments

This article describes the perspectives of using of human tissues and cells for the production of biomedical cell products, the benefits of regenerative medicine in the treatment of serious diseases, global progress in the development of these products, the current status and plans on formation of the federal legislation, the need to improve the national legal regulation and key moments in the development of good practice in the field of biomedical cell technologies.

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THE MAIN CRITERIA FOR THE CLEANROOM ACCORDING TO THE REQUIREMENTS OF GMP

Posted in 2016, Issue March 2016, PHARMACEUTICS | 0 comments

The article considers criteria of Cleanrooms which are directly dependent on the level of engineering solutions – technical infrastructure of production.

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DEVELOPMENT AND STUDY OF QUALITY INDICATORS OF THE CANDY “DENTOS” FOR TREATMENT AND PREVENTION OF INFECTIOUS AND INFLAMMATORY DISEASES OF THE ORAL CAVITY

Posted in 2016, Issue January 2016, PHARMACEUTICS | 0 comments

The article is devoted to the development of a dosage form of the drug for candy “Dentos”, which was offered previously in the form of a complex tincture for dental practices. There was substantiated the choice of optimal component composition, was studied quality parameters of the candy “Dentos” and it was determined normalizing indicators: organoleptic properties (appearance, taste, color, odor, stickiness); average weight and variation from it; wetness by K.Fisher`s method; disintegration; microbiological purity; qualitative and quantitative analysis of active substances (from the positions of modern pharmaceutical analysis).

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TO DETERMINE THE QIALITATIVE COMPOSITION OF THE URTICA DIOICA L. BY THIN-LAYER CHROMATOGRAPHY

Posted in 2016, Issue January 2016, PHARMACEUTICS | 0 comments

The article presents method of qualitative study of medicinal plant Urtica dioica L. by thin-layer chromatography with the use of high-performance records.

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KNOWLEDGE OF PHARMACISTS OF POSSIBILITY OF USE OF IMMUNOMODULATORS OF A BACTERIAL ORIGIN IN PEDIATRICS

Posted in 2015, Issue December 2015, PHARMACEUTICS | 0 comments

In article knowledge of pharmacists of immunomodulators is studied. It is established that there is a need of increase of informational content of pharmacists about medicines possessing immunomodulatory effect including possibilities of use of a likopid for prevention and pharmacotherapy of diseases of a respiratory path at the children’s population.

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STUDY OF ANTI-INFLAMMATORY ACTION OF MEDICINAL PENCILS WITH ACICLOVIR AND PHITOCOMPONENTS

Posted in 2015, Issue December 2015, PHARMACEUTICS | 0 comments

It is shown that the developed medicinal pencils with aciclovir and phytocomponents have pronounced anti-inflammatory effects in studies of pharmacological activity.

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ANALYSIS PHARMACEUTICAL OF DRUGS FOR TREATMENT OF GINGIVITIS

Posted in 2015, Issue November 2015, PHARMACEUTICS | 0 comments

The article presents the analysis of the pharmaceutical market of medicines for treatment and prevention of gingivitis. There’s also the research of composition of stomatological gels.

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