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PHARMACEUTICS

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ПИ № ФС 77 - 51217

ANALYSIS OF OPINIONS OF THE WORKERS OF PHARMACEUTICAL ORGANIZATIONS OF CAUCASIAN MINERAL WATERS FOR OVER-THE-COUNTER RELEASE OF ANTIHISTAMINE MEDICINAL DRUGS

Posted in 2017, Issue № 9(63) September 2017, PHARMACEUTICS | 0 comments

The number of registered cases of allergic rhinitis (AR) among patients increases annually. In connection with the increased relevance of this nosology, we studied the opinion of the pharmaceutical workers about the preferences of patients with AR when choosing antihistamine medicine (AM). The main criteria in the choice of pharmaceutical substitution of AM are revealed. Coincidences and differences in the opinions of pharmacists and chemists are found, as well as in the answers of respondents with different work experience. The average cost of the most popular shopping basket of antihistamines is set at 300 rubles. The most popular medicines among patients include “Suprastin,” “Erius,” “Cetrin,” “Claritin.”

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ANALYSIS OF MEDICINAL PREPARATIONS ASSORTMENT FOR THE TREATMENT OF COMMUNITY-ACQUIRED PNEUMONIA IN PHARMACY ORGANIZATIONS OF KABARDINO-BALKAR REPUBLIC

Posted in 2017, Issue № 9(63) September 2017, PHARMACEUTICS | 0 comments

The retail pharmaceutical market of the Kabardino-Balkar Republic (KBR) was studied and analyzed. Protocols for the formation of retail prices of 63 pharmacy organizations of the KBR were used as the objects of the study. It was found that 14 (78%) of the 18 INNs and their combinations recommended by the Federal Standard for the provision of medical care to patients with pneumonia are represented in the retail segment. There are preparations from a group of other medical preparations for the treatment of respiratory diseases (acetylcysteine) and antiasthmatics (ipratropium bromide + fenoterol, aminophylline, ambroxol). The fifth part of the retail market is occupied by national producers. Prices for medicines for the treatment of community-acquired pneumonia range from 8.00 rubles (Eufilin unbranded) to 2419 rubles. (Avelox). The cost of an outpatient course of treatment for community-acquired pneumonia according to the Federal Standard is calculated.

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DEVELOPMENT OF THE COMPOSITION AND TECHNOLOGY OF ANTIMICROBIAL OINTMENT

Posted in 2017, Issue № 9(63) September 2017, PHARMACEUTICS | 0 comments

The composition and technology of ointments with furacilin on various bases is developed. The highest degree of release of furacilin from ointments is observed in a sample on the basis of an alloy of polyethylene glycols. A high degree of release is observed in the first hours after the application and remains for a day. The sample of the ointment, prepared on this basis with the use of cellulose as a gel-forming agent is a little inferior in terms of speed and degree of release, but in contrast to the ointment on polyethylene glycol, the degree of release is gradually increasing.

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DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF KERATOLYTIC OINTMENT

Posted in 2017, Issue № 9(63) September 2017, PHARMACEUTICS | 0 comments

The article contains the analysis of pharmaceuticals available at the pharmaceutical market for the treatment of psoriasis. As a result, the actual use of salicylic acid in external dosage forms has been established. In order to expand the range of dosage forms, we developed the composition and technology of ointment with salicylic acid, which solved the problem of bioavailability of the ointment with a minimal risk of side effects. The degree of release from the developed ointment is higher than that of the analogues produced by the pharmaceutical industry.

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BASIS OF SUCCESS IN PHARMACEUTICAL BUSINESS – THE POWER OF MOBILIZATION AND MOTIVATION OF CHEMISTS

Posted in 2017, Issue № 8(62) August 2017, PHARMACEUTICS | 0 comments

We were faced with the task of theoretically analyzing the motivation and mobilization of employees of various drugstores and innovation aimed at achieving the best results by taking the right policy guidelines and avoiding emotional burnout of workers. In the future, we’d like to experimentally reveal the most significant motives for the work activity of pharmacists.

We conducted analysis of existing data on the motivation and mobilization of employees of an organization (in a specific aspect – pharmaceutical). The main directions and prospects are identified.

Dangers and peculiarities of emotional burnout are indicated for different categories of employees of the drugstores.

Based on the analysis and identification of the main features, we developed a questionnaire for pharmacists with subsequent analysis of profiles of motives for labour activity of chemists in Kazan.

We revealed high value of respect in the team of co-workers, social importance of labour and moral incentives in the process of motivating pharmacists by their managers.

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MARKETING RESEARCH OF MEDICINAL DRUGS AND COSMETIC MEANS THAT PREVENT BALDNESS AND STIMULATE HAIR GROWTH

Posted in 2017, Issue № 8(62) August 2017, PHARMACEUTICS | 0 comments

The problem of hair loss worries the entire population. Men suffer a reduction in the volume of the hair, linking it with a genetic predisposition and relatively calm about such changes in appearance, then for women hair loss becomes a serious problem. This problem negatively affects the psychological state of the patient. The consequence of this is poor adaptation in the society. With the problem of hair loss to a doctor or specialists in aesthetic medicine are coming only in isolated cases, regardless of gender and age. The fundamental factor in the choice of funds is their own experience and recommendations of acquaintances, with preference given to products with plant components and vitamin complexes.

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INFLUENCE OF GAS-FORMING COMPONENT QUANTITY AND COMPACTING PRESSURE ON SOLUBILITY OF EFFERVESCENT NAPROXEN TABLETS

Posted in 2017, Issue № 7(61) July 2017, PHARMACEUTICS | 0 comments

Naproxen is a non-steroidal anti-inflammatory drug that is related to the chemical structure of propionic acid derivatives. It has a wide spectrum of action and can treat pain of various geneses. The rate of manifestation of the pharmacological effect is very important when naproxen is used to stop acute pain. It can be increased by means of creating effervescent tablets with naproxen. The key characteristic of effervescent tablets is the dissolution time, which depends on a number of factors, such as the amount of gas-forming component in the tablet, the amount of compacting pressure. In this study, we examined the dependence of the influence of these two factors on the dissolution time of the effervescent naproxen tablets.

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DISTRIBUTION OF ALPHA-[3-[[2-(3.4-DIMETHOXYPHENYL)-ETHYL]-METHYLAMINO] PROPYL]-3.4-DIMETOXY-ALPHA-(1-METHYL-ETHYL) BENZOL ETHAN NITRILE IN THE ORGANISM OF WARM-BLOODED ANIMALS

Posted in 2017, Issue № 6(60) June 2017, PHARMACEUTICS | 0 comments

The article studies the distribution of alpha-[3-[[2-(3.4-dimethoxyphenyl)ethyl]-methylamino] propyl] -3.4-dimethoxy-alpha-(1-methylethyl) benzol ethan nitrile in the organism of omnivorous warm-blooded animals (rats) after intragastric infiltration of a half lethal dose of the poison agent. Isolation of alpha-[3-[[2-(3.4-dimethoxyphenyl)ethyl]-methyl-amino] propyl]-3.4-dimethoxy-alpha-(1-methylethyl) benzol ethan nitrile from organs, their contents and bio-fluids of the animals was conducted with the help of acetone. Purification of the extracted compound was carried out by chromatography on a column of “Silasorb S-18” 30 micrometers (eluent-ethan nitrile-water (9:1)). To identify and quantify the test compound, TLC, GC-MS, and UV spectro-photometry were used. The presence of the largest quantities of the tested substance is fixed in the stomach, its contents, liver and kidneys. The results obtained enable us to recommend these organs as the main objects of forensic and chemical analysis for finoptin poisoning.

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STANDARDIZATION OF “IBUPROSOL” GEL WITH APPLICATION OF ALKALIMETRIC METHOD

Posted in 2017, Issue № 6(60) June 2017, PHARMACEUTICS | 0 comments

The article offers a new soft preparation form of “Ibuprozol” based on the “Tizol” gel and containing 3.0% of ibuprofen. The ionization constant of the preparation in the water-ethanol medium was established, the curve of alkalimetric titration was calculated and drawn, and indicators were selected. A simple and reproducible method for the quantitative analysis of ibuprofen in ointments was developed. It enables us to determine the content of a pharmacologically active substance with an error within the limits of permissible norms and deviations provided for by normative and technical documentation.

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VALIDATION OF QUANTITATIVE DETERMINATION METHOD OF CHLOROXEXIDINE BIGLUCONATE IN GEL FOR DENTINE CARIES TREATMENT

Posted in 2017, Issue № 4(58) April 2017, PHARMACEUTICS | 0 comments

The paper presents the results of validation method for quantitative determination of chlorhexidine bigluconate in gel for dentine caries treatment. Lauryl-sulfate method was proposed as a means of quantitative determination of chlorhexidine bigluconate according to precipitation titration variant. The method was evaluated by validation characteristics: Analytical field of application, linearity, accuracy and precision (convergence). As a result of the conducted studies, it was found that analytical range of application of the proposed method from 80 to 120% confirmed the linear dependence of titrant consumption on the quantitative content of chlorhexidine bigluconate, the average regeneration rate comprised 99.2%. The validated procedure allows determining quantitative content of chlorhexidine bigluconate in the presence of concomitant components and can be recommended for inclusion in regulatory documentation.

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MARKETING RESEARCH OF RUSSIAN AND REGIONAL MARKET OF MEDICINAL DRUGS APPLIED FOR TREATMENT OF ACUTE INTESTINAL INFECTIONS

Posted in 2017, Issue № 4(58) April 2017, PHARMACEUTICS | 0 comments

Acute intestinal infection (AII) is one of the most significant problems of medicine and public health in general, due to the global presence and no tendency in reduction of incidence. In order to determine meeting of the need for medicines, children suffering from acute intestinal infections, the target segment of the Russian and regional pharmaceutical market (Republic of North Ossetia-Alania) and the drugs used to treat AII, were investigated. Using the marketing analysis methods, the assortment of drugs used for the treatment of acute intestinal infections of various etiologies was studied and systematized, the saturation of the regional market compared with the all-Russian one is given as well.

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THE COMPARATIVE ANALYSIS OF DOPAMINERGIC DRUGS, WHICH USED FOR A MEDICAL TREATMENT OF PARKINSON’S DISEASE AND WHICH INCLUDED INTO FEDERAL GUIDELINES FOR THE USE OF THERAPEUTIC AGENTS OF THE RUSSIAN FEDERATION

Posted in 2016, Issue November 2016, PHARMACEUTICS | 0 comments

The article states the comparative analysis of dopaminergic drugs, which used for a medical treatment of Parkinson’s disease and which included into Federal guidelines for the use of therapeutic agents of the Russian Federation. During the research we have analysed the section “Drugs for Parkinson’s disease treatment” in Federal guidelines for the use of therapeutic agents of the Russian Federation published in 2010, 2013, 2016. The comparative analysis of the dopaminergic drugs revealed that in the list of agents for medical treatment of this disease there are some changes and additions every year. It is found that in the latest editions of Federal guidelines additional tradenames of therapeutic agents with more accessible forms of issuance and dosage are provided, what improves the quality of medical treatment of Parkinson’s disease and also produces a necessary degree of comfort in a usage of a medicament or in a correction of a dose.

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THE ROLE OF CERULOPLASMININ THE Α2- GLOBULIN FRACTION OF PROTEIN METABOLISM IN THE LIVER INDUCED BY CARBON TETRACHLORIDE AND ITS CORRECTION BY PHYTOCOMPOSITION №1 + PHYTOF 

Posted in 2016, Issue August 2016, PHARMACEUTICS | 0 comments

The pharmacological effect of the total extract of Phyto composition №1 + PhytoF (F№1 + PhytoF) on the functional state of hepatocytes, namely the metabolism of proteins, in comparison with the classical hepatoprotectorEssentiale forte N (EFN) and extract of Paliurusspina-christi (PSCh), which is in the composition of (F№1 + PhytoF), was studied in rabbits with liver induced by carbon tetrachloride. To this end,the complete analysis of total protein, albumin, globulin, and ceruloplasmin (CP), which is in the composition of the α2-globulin fraction as one of the main components of the antioxidant defense system and the response of the organism to stress factors, was performedand the protein coefficient was determined. The research showed thatamong the investigated proteinsin allgroups of studied animals, the pharmacological activity of F№1+PhytoF had the greatest effect on the synthesis of CP and globulin fraction content. Further, in a comparative aspect, the coefficient of variation from controls (CV) for (F№1 + F), (EPN), (PSCh) was determined by (CP),and based on the data of the changes of the protein fractions, hepatoprotective activity of the studied compounds was established.

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COMPARATIVE ANALYSIS OF THERMAL WATER USED FOR THE CARE OF SKIN

Posted in 2016, Issue August 2016, PHARMACEUTICS | 0 comments

In article the concept of thermal waters, which are extracted from underground sources and their temperature is always above ambient, and fits most 30°C. as the classification of thermal waters, used for the care of the skin depending on salinity and Ph, the comparative analysis of ion composition of the thermal water production in France and Russia. Determined the effect of these thermal waters on the skin which with constant use softens skin, possesses anti-inflammatory properties and accelerates skin regeneration.

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MORPHOLOGICAL AND ANATOMICAL DIAGNOSTIC FEATURES FEVERWEED CAUCASIAN AND ERYNGIUM PLANUM

Posted in 2016, Issue July 2016, PHARMACEUTICS | 0 comments

Studied the microstructure of roots, stems and leaves of Eryngium planum and feverweed Caucasus in order to establish diagnostic features and secretory structures. The obtained results allow to identify plant material and can be used in the development of a regulatory document under the heading “Microscopy”. Essential oil tubules found in the roots, stems, petioles and leaf blades. They are located in the roots in the phloem and pericyclic zone, accompanied by vascular bundles in the aboveground organs. Branching stem in inflorescence false – dichotomy. Leaf blade dorsoventral type amfistomaticheskaya.

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COMPETITIVENESS NETWORK PHARMACY IN VELIKY NOVGOROD

Posted in 2016, Issue June 2016, PHARMACEUTICS | 0 comments

In market conditions the competitiveness of the organization is one of the important tasks of modern pharmacy. This index is examined on pharmacy chains in Veliky Novgorod. In our study, the concordance coefficient is 0.58, it indicates the consensus of expert opinions. They chose the location of pharmacy, its assortment of goods, staff qualification and the level of prices as the most important factors of the competitiveness. Based on expert opinions and survey of visitors in network pharmacies integral competitiveness index ranged from 0.915 to 0.949, it demonstrates that all three network pharmacies are sufficiently strong competitors. However, the calculation of each parameter of competitiveness from the viewpoint of buyers identified capabilities to improve the work of pharmacies.

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EFFECT OF DIFFERENT SIZED ZINC COMPOUNDS ON THE LIFTING FORCE OF THE TEST CULTURE SACCHAROMYCES CEREVISIAE

Posted in 2016, Issue May 2016, PHARMACEUTICS | 0 comments

The article presented a study of the effects of inorganic Zn compounds of various size and morphology (technical samples ZnO, Zn(OH)2 and ZnSO4, micronized by different ways ZnO samples and synthesized nanoscaled Zn(OH)2) to the lifting force of the test culture of Saccharomyces cerevisiae. High activity of slightly soluble connections when comparing with an ionic form is shown. Dependence of a biological response on morphology and dimension of the studied connections is observed.

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ANALYSIS OF THE USE OF ANTIFUNGAL MEDICATIONS AT THE STAGE OF A COURSE OF TREATMENT AND DEFINITION OF VALUATION THE TREATMENT OF PATIENTS WITH FUNGAL LESIONS OF THE SKIN AND NAILS

Posted in 2016, Issue May 2016, PHARMACEUTICS | 0 comments

The treatment of fungal diseases is a rather complicated process, requiring the use of fungicidal and fungistaticescoe drugs. It is known that the effectiveness of traditional treatment regimens is low. The use of modern antifungal drugs improves the effectiveness of therapy of fungal diseases. Analyzes the use of antifungal drugs in various dosage forms for the treatment of fungal infections of the skin and nails.

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THE SEARCH DEPENDENCE OF HYPOGLYCEMIC ACTIVITY FROM THE IONIZATION CONSTANTS IN THE SERIES OF N’–ACYLHYDRAZIDES OF N–ACYL–5–BROMO(5–IODO)ANTHRANILIC ACIDS

Posted in 2016, Issue May 2016, PHARMACEUTICS | 0 comments

The values of ionization constants (pKa and pKв) of 6 substances of N’-acylhydrazides of N-acyl-5-bromo(5-iodo)anthranilic acids by method of potential semi-neutralization are experimentally defined. It is transacted the analysis of regression and received 6 correlation equations connecting the pKa and pKв with experimentally defined hypoglycemic activity (HGAexp.). Values of HGA action with use of the made equations are calculated. It is experimentally defined HGAexp. of investigated 2 substances which by results of biological tests are active. To assess the HGA prediction compared with HGAexp., computed confidence interval of the individual prediction.

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VIOLATIONS OF ERYTHROCYTES MEMBRANES FATTY ACIDS PATTERN AT THE NITROGEN OXIDES INTOXICATION AND THEIR PREVENTION BY PLANT EXTRACTS

Posted in 2016, Issue April 2016, PHARMACEUTICS | 0 comments

Pilot studies on studying of preventive introduction of the «Kalifen» extractemitted from a guelder-rose (Viburnum sargentii Koechne) and extract of an eleuterokokk to intoxication with nitrogen oxides are conducted. It was shown that intoxication nitrogen oxides was followed by violation in the ratio of fatty acids in a membrane of erythrocytes: the amount of saturated fatty acids increased and the amount of nonsaturated fatty acids decreased. Preliminary introduction of a kalifen to intoxication nitrogen oxides in a greater degree possessed protective effect on the fatty acids in erythrocyte membranes, than that at introduction extract eleuterococcus.

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