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PHARMACEUTICS

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ПИ № ФС 77 - 51217, 16+

QUALITATIVE AND QUANTITATIVE DETERMINATION OF FLAVONOIDS IN CITRUS LIMONIA (L.)

Posted in 2020, Issue № 10(100) October 2020, PHARMACEUTICS | 0 comments

The authors provide a qualitative and quantitative determination of the flavonoid composition in the Citrus limonia (L.) peel. Qualitative determination of the flavonoid composition was carried out in alcohol extraction by paper chromatography method after preliminary removal of lipophilic substances and comparing the results with standard samples. Chromatograms were examined in visible and UV light, followed by treatment with ammonia vapor, 2% sodium borohydride solution with concentrated hydrochloric acid, 2% alcoholic solution of aluminum chloride. The quantitative content of flavonoids was determined by a direct spectrophotometric method without using the complexation reaction with aluminum chloride. The extraction of flavonoids from the raw material was carried out with a mixture of dimethyl sulfoxide – ethanol in the ratio (10: 2). Flavanones such as hesperidin, naringin, hesperetin, as well as flavones diosmin and apigenin glycoside were found in the extract from the peel of Citrus limonia (L.) fruits.

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DEVELOPMENT OF NEW ANTI-INFLAMMATORY OINTMENT

Posted in 2014, Issue November 2014, PHARMACEUTICS | 0 comments

The article deals with the data on the development of the optimal composition of a new anti-inflammatory ointment containing infusion uliginose and honey, matching its standard documentation for expanding the range of domestic effective and safe drugs of natural origin.

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POLYPHENOLIC COMPOUNDS OF THE FRUIT OF THE VIRGINIA CHERRY (PADUS VIRGINIANA MILL.)

Posted in 2020, Issue № 07(97) July 2020, PHARMACEUTICS | 0 comments

A comparative morphological-anatomical and phytochemical study of the fruits of common cherry (Padus avium Mill.) and virgin cherry (Padus virginiana Mill.) as a promising source of biologically active substances. It was found that samples of common cherry fruit harvested on the territory of the Orenburg region meet the requirements of FS.2.5.0049.15 “Common Cherry fruit” on the content of tannins and anthocyanins. It is shown that the fruits of the cherry virginiana does not differ from the fruits of common cherry in the content of the sum of tannins (in terms of tannin), flavonoids (in terms of rutin), anthocyanins (in terms of cyanidin-3-O-glucoside).

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REGULATION OF BIOLOGICAL RHYTHMS. MODERN METHODS OF DESYNCHRONOSES CORRECTION

Posted in 2020, Issue № 07(97) July 2020, PHARMACEUTICS | 0 comments

Violations of the biological rhythms of the body occur because of the mismatch of its internal rhythms. The reasons for this mismatch can be both the pathology of the systems or organs, as well as transmeridian flights, or night shifts at work. In turn, the violation of the natural structure of biorhythms (desynchronosis) leads to further violations of the body’s adaptation process. Desynchronosis is manifested in sleep disturbance, headaches, daytime drowsiness, decreased performance, decreased body resistance, etc.

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THE SOLUBILIZATION CAPACITY OF HYDROXYPROPYL-β-CYCLODEXTRIN AND FORMING INCLUSION COMPLEXES

Posted in 2014, Issue October 2014, PHARMACEUTICS | 0 comments

The solubilizing ability of hydroxypropyl-β-cyclodextrin and preparation of inclusion complexes of drugs with limited solubility in water were described.

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A RATIONAL APPROACH TO THE SELECTION OF PHARMACOLOGIC TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS

Posted in 2014, Issue October 2014, PHARMACEUTICS | 0 comments

The aim of word is to appraise on the basis of clinical studies the clinical effectiveness and course the cost of drugs belonging to different pharmacological groups, for the therapy of postmenopausal osteoporosis: Alendronate (bisphosphonates), Strontium ranelate (drugs strontium), Miacalciс (calcitonin), Progynova (estrogens).

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DEVELOPMENT OF TECHNOLOGY AND COSMETIC PRODUCTS FOR THE TREATMENT AND PREVENTION OF ALOPECIA ON THE BASIS OF MEDICINAL HERBS

Posted in 2014, Issue August 2014, PHARMACEUTICS | 0 comments

This article focuses on such an important issue as alopecia. It is found that the most common disease of the hair is alopecia. Identified and the necessity of creating kosmotsevticheskogo means based on natural vegetable raw materials for the treatment and prevention of alopecia. According to the literature, the most efficient plants in the treatment of hair loss are: Rosemary officinalis, St. John’s wort, Ginger medical, Sorbus aucuparia, Nettle, Hops ordinary. The study results were obtained confirming the highest yield of biologically active substances from plant material by grinding it in a ball mill.

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RELEVANCE OF DETERMINATION OF BARBITURIC ACID DERIVATIVES BY CHEMICAL AND TOXICOLOGICAL ANALYSIS ON EXAMPLE OF CYCLOBARBITAL

Posted in 2020, Issue № 03(93) March 2020, PHARMACEUTICS | 0 comments

The relevance of the chemical and toxicological analysis for derivatives of barbituric acid are due to common poisoning with these substances and in a mixture with other toxicologically important drugs [4], [5], [6]. The basis of the expert assessment of poisoning with derivatives of barbituric acid is a qualitative determination of the drug in the human body, considering the circumstances of the case and the clinical picture of poisoning; however, it is possible to quantify the detected drugs and their metabolites. A transparent scheme of chemical-toxicological analysis was compiled and optimized in forensic chemical expert studies of biological objects to improve the diagnosis of poisoning with derivatives of barbituric acid.

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PHARMACOEPIDEMIOLOGICAL THERAPY MONITORING OF ACUTE MYOCARDIAL INFARCTION

Posted in 2014, Issue June 2014, PHARMACEUTICS | 0 comments

Conducted a retrospective pharmacoepidemiological study of case histories of patients with acute myocardial infarction treated at medical organizations in Nizhny Novgorod showed that the real practice of pharmacotherapy of acute myocardial infarction is not enough rational and do not meet modern standards of treatment.

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EFFICIENCY OF SURFAGON DRUG ON COWS AND PIGS, IN INCREASING FERTILITY AFTER INSEMINATION

Posted in 2019, Issue № 11(89) November 2019, PHARMACEUTICS | 0 comments

The paper presents data obtained as a result of the use of Surfagon drugs of various manufacturers. The studied preparations contain hormonal substances that stimulate and regulate the sexual function of female productive animals. The tests were carried out in the subsidiary farm of the Smolensk region on cows of brown Schwyz breed and sows of large white breed, with natural mating under human control. The analysis of the results obtained as a result of the experiment is carried out as well.

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USE OF SFE METHOD FOR THE EXTRACTION OF A DERIVANT OF 3-HYDROXY-3-PYRROLIN-2-ONE FROM BLOOD PLASMA

Posted in 2019, Issue № 11(89) November 2019, PHARMACEUTICS | 0 comments

The high growth of diseases associated with impaired basic cognitive functions necessitates the search and implementation of new and effective nootropic drugs in medical practice.

The biologically active compound of 1-aminocarbonylmethy-4-acetyl-5-(4-bromophenyl)-3-hydroxy-3-pyrrolin-2-one synthesized at the Perm State Pharmaceutical Academy was recommended for preclinical studies as a potential nootropic agent.

Currently, the practice of preclinical studies for the isolation of drugs from biological fluids is widely used in solid-phase extraction (SPE), which allows one to combine isolation and purification from coextracting substances of the biological matrix.

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EXTRACT FROM AXES OF INFLORESCENCES OF ARALIA MANDCHURICA – MEANS FOR PREVENTION OF STRESSFUL STRUTURAL CHANGES OF ERYTHROCYTES

Posted in 2014, Issue March 2014, PHARMACEUTICS | 0 comments

It is shown, that stress was accompanied by violation of dimensional characteristics of erythrocytes and their osmotic resistance, system of antioxidant protection, a ratio of phospholipids fractions in membranes. Effect of extract from axes of inflorescences of an Аralia мandchurica appeared more effective in restoration of the studied fiziologo-biochemical parameters of erythrocytes, than at reference a stress protector «Extract eleutherococcus». Addition of extract aralia or extract eleutherococcus to a daily diet or in the structure of food stuffs will allow to solve a problem of prevention of stressors diseases.

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FEATURES OF WATER TREATMENT SYSTEM VALIDATION IN EXPERIMENTAL PRODUCTION

Posted in 2018, Issue №7(73) July 2018, PHARMACEUTICS | 0 comments

The results of water treatment validation are presented in the paper. Water treatment for the pharmaceutical industry plays an important role in the production of a quality product and the reproduction of proper cleaning processes. The validation process is a mandatory requirement in the manufacture of medicines and is carried out to determine critical points in the operation of equipment and technological processes [1]. Due to the lack of a generally accepted standard that regulates the document flow during the validation of water treatment systems, the validation master VMP-01 “Validation of a water treatment system and distribution of purified water in pilot production” was compiled on the basis of a scientific center of anti-infectious drugs. This validation master plan provides a water sampling scheme from 10 points, the monitoring of which proceeds according to the scheme in 3 stages according to the requirements of the international standard GMP. Control of purified water is carried out in accordance with the requirements of the GF RK [2,3].

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METHODOLOGY OF DETERMINATION OF 2-DIMETHYLAMINO-1,3-BIS- (PHENYLSULPHONYLTHIO) PROPANE IN BLOOD AND ITS VALIDATION

Posted in 2018, Issue №3(69) March 2018, PHARMACEUTICS | 0 comments

The features of the isolation of 2-dimethylamino-1,3-bis-(phenylsulfonylthio) propane (bensultap) from its model mixtures with blood ethyl acetate in the infusion regime were studied. To sufficiently extract 2-dimethylamino-1,3-bis (phenylsulfonylthio) propane ethyl acetate from the blood, it is necessary to insult the biological matrix with ethyl acetate twice if the weight ratio of the isolating agent and the biomaterial is at least 2:1, and the duration of each infusion is not less than 30 minutes. The purification of the analyte from the endogenous substances of the biofluid is carried out in a column of silica gel L 40/100 μm, eluting with hexane, and then with a mixture of hexane-dioxane-propanol-2 (8:3:0.6). A procedure for the determination of 2-dimethylamino-1,3-bis (phenylsulfonylthio) propane in the blood was developed based on the HELC method, validated according to the criteria of linearity, accuracy, precision, and stability. The limits of detection and quantitation of the analyte are 1.75 μg/g and 2.25 μg/g, respectively.

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DEVELOPMENT OF VIRTUAL LABORATORY FOR MEDICAL SPECIALTIES WITHIN FRAMEWORK OF CLASSICAL UNIVERSITY

Posted in 2018, Issue №3(69) March 2018, PHARMACEUTICS | 0 comments

The virtual chemical laboratory, located on the distance learning portal, is an effective tool for enhancing and motivating students to the learning process. The virtual chemical laboratory includes a large number of experiments, which is visualized using a combination of three-dimensional animation, real-time graphics and an animated character. The use of a virtual chemical laboratory in the process of preparing pharmaceutical personnel within the framework of the classical university increases the students’ understanding of chemical processes and helps them to master the necessary skills of conducting a laboratory workshop.

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ANATOMICAL STRUCTURE OF VEGETATIVE ORGANS OF WOOD GERANIUM (GERANIUM SYLVATICUM L.)

Posted in 2018, Issue №1(67) January 2018, PHARMACEUTICS | 0 comments

The Geranium genus (Geranium L.) includes more than 350 species, distributed mainly in a middle latitudes. One of the widely spread species in the Kursk region is a wood geranium (Geranium sylvaticum L.). Wood geranium contains a complex of biologically active substances and is widely used in folk medicine for the treatment of various diseases, which makes it possible to consider this plant a promising for scientific medicine. The possibility of the use of a new type of raw material in scientific medicine makes it necessary to study the anatomical structure of the vegetative organs of wood geranium. The revealed features of the anatomical structure of a stem and a leaf can be used to diagnostics of the medicinal raw material of this plant.

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STUDY OF DEMAND FOR IBUPROPHEN CONTAINING DRUGS

Posted in 2018, Issue №1(67) January 2018, PHARMACEUTICS | 0 comments

A study of the assortment of nonsteroidal anti-inflammatory drugs containing ibuprofen is conducted in the paper. It is found that there are 17 (of 23) samples of ibuprofen containing products on the pharmaceutical market of Pyatigorsk. The assortment of pharmacies includes 12 brands of mono-preparations and 5 combined ones. The consumer demand for these drugs is studied and it is revealed that medicines in the form of tablets (70.4%) are in demand, since they have a low price, the optimal dose and dose frequency.

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MARKETING RESEARCH OF ASSORTMENT OF ANTACID MEDICINES OF OVER-THE-COUNTER LEAVE IN PHARMACY ORGANIZATIONS

Posted in 2017, Issue №12(66) December 2017, PHARMACEUTICS | 0 comments

Comparative marketing researches of the group of antacid medicines of over-the-counter leave in two pharmacy organizations were conducted. The main marketing parameters of this sector of the market are established: List and structure of antacid medicinal products segment for medicinal forms, manufacturing countries, pharmaceutical distributors, sources of origin as well as the list of vital and essential drugs. The analysis of drugs of this group was carried out according to the cost, amount and level of income received by pharmacies.

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ANALYSIS OF OPINIONS OF THE WORKERS OF PHARMACEUTICAL ORGANIZATIONS OF CAUCASIAN MINERAL WATERS FOR OVER-THE-COUNTER RELEASE OF ANTIHISTAMINE MEDICINAL DRUGS

Posted in 2017, Issue № 9(63) September 2017, PHARMACEUTICS | 0 comments

The number of registered cases of allergic rhinitis (AR) among patients increases annually. In connection with the increased relevance of this nosology, we studied the opinion of the pharmaceutical workers about the preferences of patients with AR when choosing antihistamine medicine (AM). The main criteria in the choice of pharmaceutical substitution of AM are revealed. Coincidences and differences in the opinions of pharmacists and chemists are found, as well as in the answers of respondents with different work experience. The average cost of the most popular shopping basket of antihistamines is set at 300 rubles. The most popular medicines among patients include “Suprastin,” “Erius,” “Cetrin,” “Claritin.”

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ANALYSIS OF MEDICINAL PREPARATIONS ASSORTMENT FOR THE TREATMENT OF COMMUNITY-ACQUIRED PNEUMONIA IN PHARMACY ORGANIZATIONS OF KABARDINO-BALKAR REPUBLIC

Posted in 2017, Issue № 9(63) September 2017, PHARMACEUTICS | 0 comments

The retail pharmaceutical market of the Kabardino-Balkar Republic (KBR) was studied and analyzed. Protocols for the formation of retail prices of 63 pharmacy organizations of the KBR were used as the objects of the study. It was found that 14 (78%) of the 18 INNs and their combinations recommended by the Federal Standard for the provision of medical care to patients with pneumonia are represented in the retail segment. There are preparations from a group of other medical preparations for the treatment of respiratory diseases (acetylcysteine) and antiasthmatics (ipratropium bromide + fenoterol, aminophylline, ambroxol). The fifth part of the retail market is occupied by national producers. Prices for medicines for the treatment of community-acquired pneumonia range from 8.00 rubles (Eufilin unbranded) to 2419 rubles. (Avelox). The cost of an outpatient course of treatment for community-acquired pneumonia according to the Federal Standard is calculated.

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