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PHARMACEUTICS

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ПИ № ФС 77 - 51217, 18+

FEATURES OF WATER TREATMENT SYSTEM VALIDATION IN EXPERIMENTAL PRODUCTION

Posted in 2018, Issue №7(73) July 2018, PHARMACEUTICS | 0 comments

The results of water treatment validation are presented in the paper. Water treatment for the pharmaceutical industry plays an important role in the production of a quality product and the reproduction of proper cleaning processes. The validation process is a mandatory requirement in the manufacture of medicines and is carried out to determine critical points in the operation of equipment and technological processes [1]. Due to the lack of a generally accepted standard that regulates the document flow during the validation of water treatment systems, the validation master VMP-01 “Validation of a water treatment system and distribution of purified water in pilot production” was compiled on the basis of a scientific center of anti-infectious drugs. This validation master plan provides a water sampling scheme from 10 points, the monitoring of which proceeds according to the scheme in 3 stages according to the requirements of the international standard GMP. Control of purified water is carried out in accordance with the requirements of the GF RK [2,3].

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METHODOLOGY OF DETERMINATION OF 2-DIMETHYLAMINO-1,3-BIS- (PHENYLSULPHONYLTHIO) PROPANE IN BLOOD AND ITS VALIDATION

Posted in 2018, Issue №3(69) March 2018, PHARMACEUTICS | 0 comments

The features of the isolation of 2-dimethylamino-1,3-bis-(phenylsulfonylthio) propane (bensultap) from its model mixtures with blood ethyl acetate in the infusion regime were studied. To sufficiently extract 2-dimethylamino-1,3-bis (phenylsulfonylthio) propane ethyl acetate from the blood, it is necessary to insult the biological matrix with ethyl acetate twice if the weight ratio of the isolating agent and the biomaterial is at least 2:1, and the duration of each infusion is not less than 30 minutes. The purification of the analyte from the endogenous substances of the biofluid is carried out in a column of silica gel L 40/100 μm, eluting with hexane, and then with a mixture of hexane-dioxane-propanol-2 (8:3:0.6). A procedure for the determination of 2-dimethylamino-1,3-bis (phenylsulfonylthio) propane in the blood was developed based on the HELC method, validated according to the criteria of linearity, accuracy, precision, and stability. The limits of detection and quantitation of the analyte are 1.75 μg/g and 2.25 μg/g, respectively.

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DEVELOPMENT OF VIRTUAL LABORATORY FOR MEDICAL SPECIALTIES WITHIN FRAMEWORK OF CLASSICAL UNIVERSITY

Posted in 2018, Issue №3(69) March 2018, PHARMACEUTICS | 0 comments

The virtual chemical laboratory, located on the distance learning portal, is an effective tool for enhancing and motivating students to the learning process. The virtual chemical laboratory includes a large number of experiments, which is visualized using a combination of three-dimensional animation, real-time graphics and an animated character. The use of a virtual chemical laboratory in the process of preparing pharmaceutical personnel within the framework of the classical university increases the students’ understanding of chemical processes and helps them to master the necessary skills of conducting a laboratory workshop.

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ANATOMICAL STRUCTURE OF VEGETATIVE ORGANS OF WOOD GERANIUM (GERANIUM SYLVATICUM L.)

Posted in 2018, Issue №1(67) January 2018, PHARMACEUTICS | 0 comments

The Geranium genus (Geranium L.) includes more than 350 species, distributed mainly in a middle latitudes. One of the widely spread species in the Kursk region is a wood geranium (Geranium sylvaticum L.). Wood geranium contains a complex of biologically active substances and is widely used in folk medicine for the treatment of various diseases, which makes it possible to consider this plant a promising for scientific medicine. The possibility of the use of a new type of raw material in scientific medicine makes it necessary to study the anatomical structure of the vegetative organs of wood geranium. The revealed features of the anatomical structure of a stem and a leaf can be used to diagnostics of the medicinal raw material of this plant.

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STUDY OF DEMAND FOR IBUPROPHEN CONTAINING DRUGS

Posted in 2018, Issue №1(67) January 2018, PHARMACEUTICS | 0 comments

A study of the assortment of nonsteroidal anti-inflammatory drugs containing ibuprofen is conducted in the paper. It is found that there are 17 (of 23) samples of ibuprofen containing products on the pharmaceutical market of Pyatigorsk. The assortment of pharmacies includes 12 brands of mono-preparations and 5 combined ones. The consumer demand for these drugs is studied and it is revealed that medicines in the form of tablets (70.4%) are in demand, since they have a low price, the optimal dose and dose frequency.

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MARKETING RESEARCH OF ASSORTMENT OF ANTACID MEDICINES OF OVER-THE-COUNTER LEAVE IN PHARMACY ORGANIZATIONS

Posted in 2017, Issue №12(66) December 2017, PHARMACEUTICS | 0 comments

Comparative marketing researches of the group of antacid medicines of over-the-counter leave in two pharmacy organizations were conducted. The main marketing parameters of this sector of the market are established: List and structure of antacid medicinal products segment for medicinal forms, manufacturing countries, pharmaceutical distributors, sources of origin as well as the list of vital and essential drugs. The analysis of drugs of this group was carried out according to the cost, amount and level of income received by pharmacies.

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ANALYSIS OF OPINIONS OF THE WORKERS OF PHARMACEUTICAL ORGANIZATIONS OF CAUCASIAN MINERAL WATERS FOR OVER-THE-COUNTER RELEASE OF ANTIHISTAMINE MEDICINAL DRUGS

Posted in 2017, Issue № 9(63) September 2017, PHARMACEUTICS | 0 comments

The number of registered cases of allergic rhinitis (AR) among patients increases annually. In connection with the increased relevance of this nosology, we studied the opinion of the pharmaceutical workers about the preferences of patients with AR when choosing antihistamine medicine (AM). The main criteria in the choice of pharmaceutical substitution of AM are revealed. Coincidences and differences in the opinions of pharmacists and chemists are found, as well as in the answers of respondents with different work experience. The average cost of the most popular shopping basket of antihistamines is set at 300 rubles. The most popular medicines among patients include “Suprastin,” “Erius,” “Cetrin,” “Claritin.”

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ANALYSIS OF MEDICINAL PREPARATIONS ASSORTMENT FOR THE TREATMENT OF COMMUNITY-ACQUIRED PNEUMONIA IN PHARMACY ORGANIZATIONS OF KABARDINO-BALKAR REPUBLIC

Posted in 2017, Issue № 9(63) September 2017, PHARMACEUTICS | 0 comments

The retail pharmaceutical market of the Kabardino-Balkar Republic (KBR) was studied and analyzed. Protocols for the formation of retail prices of 63 pharmacy organizations of the KBR were used as the objects of the study. It was found that 14 (78%) of the 18 INNs and their combinations recommended by the Federal Standard for the provision of medical care to patients with pneumonia are represented in the retail segment. There are preparations from a group of other medical preparations for the treatment of respiratory diseases (acetylcysteine) and antiasthmatics (ipratropium bromide + fenoterol, aminophylline, ambroxol). The fifth part of the retail market is occupied by national producers. Prices for medicines for the treatment of community-acquired pneumonia range from 8.00 rubles (Eufilin unbranded) to 2419 rubles. (Avelox). The cost of an outpatient course of treatment for community-acquired pneumonia according to the Federal Standard is calculated.

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DEVELOPMENT OF THE COMPOSITION AND TECHNOLOGY OF ANTIMICROBIAL OINTMENT

Posted in 2017, Issue № 9(63) September 2017, PHARMACEUTICS | 0 comments

The composition and technology of ointments with furacilin on various bases is developed. The highest degree of release of furacilin from ointments is observed in a sample on the basis of an alloy of polyethylene glycols. A high degree of release is observed in the first hours after the application and remains for a day. The sample of the ointment, prepared on this basis with the use of cellulose as a gel-forming agent is a little inferior in terms of speed and degree of release, but in contrast to the ointment on polyethylene glycol, the degree of release is gradually increasing.

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DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF KERATOLYTIC OINTMENT

Posted in 2017, Issue № 9(63) September 2017, PHARMACEUTICS | 0 comments

The article contains the analysis of pharmaceuticals available at the pharmaceutical market for the treatment of psoriasis. As a result, the actual use of salicylic acid in external dosage forms has been established. In order to expand the range of dosage forms, we developed the composition and technology of ointment with salicylic acid, which solved the problem of bioavailability of the ointment with a minimal risk of side effects. The degree of release from the developed ointment is higher than that of the analogues produced by the pharmaceutical industry.

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BASIS OF SUCCESS IN PHARMACEUTICAL BUSINESS – THE POWER OF MOBILIZATION AND MOTIVATION OF CHEMISTS

Posted in 2017, Issue № 8(62) August 2017, PHARMACEUTICS | 0 comments

We were faced with the task of theoretically analyzing the motivation and mobilization of employees of various drugstores and innovation aimed at achieving the best results by taking the right policy guidelines and avoiding emotional burnout of workers. In the future, we’d like to experimentally reveal the most significant motives for the work activity of pharmacists.

We conducted analysis of existing data on the motivation and mobilization of employees of an organization (in a specific aspect – pharmaceutical). The main directions and prospects are identified.

Dangers and peculiarities of emotional burnout are indicated for different categories of employees of the drugstores.

Based on the analysis and identification of the main features, we developed a questionnaire for pharmacists with subsequent analysis of profiles of motives for labour activity of chemists in Kazan.

We revealed high value of respect in the team of co-workers, social importance of labour and moral incentives in the process of motivating pharmacists by their managers.

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MARKETING RESEARCH OF MEDICINAL DRUGS AND COSMETIC MEANS THAT PREVENT BALDNESS AND STIMULATE HAIR GROWTH

Posted in 2017, Issue № 8(62) August 2017, PHARMACEUTICS | 0 comments

The problem of hair loss worries the entire population. Men suffer a reduction in the volume of the hair, linking it with a genetic predisposition and relatively calm about such changes in appearance, then for women hair loss becomes a serious problem. This problem negatively affects the psychological state of the patient. The consequence of this is poor adaptation in the society. With the problem of hair loss to a doctor or specialists in aesthetic medicine are coming only in isolated cases, regardless of gender and age. The fundamental factor in the choice of funds is their own experience and recommendations of acquaintances, with preference given to products with plant components and vitamin complexes.

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INFLUENCE OF GAS-FORMING COMPONENT QUANTITY AND COMPACTING PRESSURE ON SOLUBILITY OF EFFERVESCENT NAPROXEN TABLETS

Posted in 2017, Issue № 7(61) July 2017, PHARMACEUTICS | 0 comments

Naproxen is a non-steroidal anti-inflammatory drug that is related to the chemical structure of propionic acid derivatives. It has a wide spectrum of action and can treat pain of various geneses. The rate of manifestation of the pharmacological effect is very important when naproxen is used to stop acute pain. It can be increased by means of creating effervescent tablets with naproxen. The key characteristic of effervescent tablets is the dissolution time, which depends on a number of factors, such as the amount of gas-forming component in the tablet, the amount of compacting pressure. In this study, we examined the dependence of the influence of these two factors on the dissolution time of the effervescent naproxen tablets.

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DISTRIBUTION OF ALPHA-[3-[[2-(3.4-DIMETHOXYPHENYL)-ETHYL]-METHYLAMINO] PROPYL]-3.4-DIMETOXY-ALPHA-(1-METHYL-ETHYL) BENZOL ETHAN NITRILE IN THE ORGANISM OF WARM-BLOODED ANIMALS

Posted in 2017, Issue № 6(60) June 2017, PHARMACEUTICS | 0 comments

The article studies the distribution of alpha-[3-[[2-(3.4-dimethoxyphenyl)ethyl]-methylamino] propyl] -3.4-dimethoxy-alpha-(1-methylethyl) benzol ethan nitrile in the organism of omnivorous warm-blooded animals (rats) after intragastric infiltration of a half lethal dose of the poison agent. Isolation of alpha-[3-[[2-(3.4-dimethoxyphenyl)ethyl]-methyl-amino] propyl]-3.4-dimethoxy-alpha-(1-methylethyl) benzol ethan nitrile from organs, their contents and bio-fluids of the animals was conducted with the help of acetone. Purification of the extracted compound was carried out by chromatography on a column of “Silasorb S-18” 30 micrometers (eluent-ethan nitrile-water (9:1)). To identify and quantify the test compound, TLC, GC-MS, and UV spectro-photometry were used. The presence of the largest quantities of the tested substance is fixed in the stomach, its contents, liver and kidneys. The results obtained enable us to recommend these organs as the main objects of forensic and chemical analysis for finoptin poisoning.

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STANDARDIZATION OF “IBUPROSOL” GEL WITH APPLICATION OF ALKALIMETRIC METHOD

Posted in 2017, Issue № 6(60) June 2017, PHARMACEUTICS | 0 comments

The article offers a new soft preparation form of “Ibuprozol” based on the “Tizol” gel and containing 3.0% of ibuprofen. The ionization constant of the preparation in the water-ethanol medium was established, the curve of alkalimetric titration was calculated and drawn, and indicators were selected. A simple and reproducible method for the quantitative analysis of ibuprofen in ointments was developed. It enables us to determine the content of a pharmacologically active substance with an error within the limits of permissible norms and deviations provided for by normative and technical documentation.

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VALIDATION OF QUANTITATIVE DETERMINATION METHOD OF CHLOROXEXIDINE BIGLUCONATE IN GEL FOR DENTINE CARIES TREATMENT

Posted in 2017, Issue № 4(58) April 2017, PHARMACEUTICS | 0 comments

The paper presents the results of validation method for quantitative determination of chlorhexidine bigluconate in gel for dentine caries treatment. Lauryl-sulfate method was proposed as a means of quantitative determination of chlorhexidine bigluconate according to precipitation titration variant. The method was evaluated by validation characteristics: Analytical field of application, linearity, accuracy and precision (convergence). As a result of the conducted studies, it was found that analytical range of application of the proposed method from 80 to 120% confirmed the linear dependence of titrant consumption on the quantitative content of chlorhexidine bigluconate, the average regeneration rate comprised 99.2%. The validated procedure allows determining quantitative content of chlorhexidine bigluconate in the presence of concomitant components and can be recommended for inclusion in regulatory documentation.

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MARKETING RESEARCH OF RUSSIAN AND REGIONAL MARKET OF MEDICINAL DRUGS APPLIED FOR TREATMENT OF ACUTE INTESTINAL INFECTIONS

Posted in 2017, Issue № 4(58) April 2017, PHARMACEUTICS | 0 comments

Acute intestinal infection (AII) is one of the most significant problems of medicine and public health in general, due to the global presence and no tendency in reduction of incidence. In order to determine meeting of the need for medicines, children suffering from acute intestinal infections, the target segment of the Russian and regional pharmaceutical market (Republic of North Ossetia-Alania) and the drugs used to treat AII, were investigated. Using the marketing analysis methods, the assortment of drugs used for the treatment of acute intestinal infections of various etiologies was studied and systematized, the saturation of the regional market compared with the all-Russian one is given as well.

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THE COMPARATIVE ANALYSIS OF DOPAMINERGIC DRUGS, WHICH USED FOR A MEDICAL TREATMENT OF PARKINSON’S DISEASE AND WHICH INCLUDED INTO FEDERAL GUIDELINES FOR THE USE OF THERAPEUTIC AGENTS OF THE RUSSIAN FEDERATION

Posted in 2016, Issue November 2016, PHARMACEUTICS | 0 comments

The article states the comparative analysis of dopaminergic drugs, which used for a medical treatment of Parkinson’s disease and which included into Federal guidelines for the use of therapeutic agents of the Russian Federation. During the research we have analysed the section “Drugs for Parkinson’s disease treatment” in Federal guidelines for the use of therapeutic agents of the Russian Federation published in 2010, 2013, 2016. The comparative analysis of the dopaminergic drugs revealed that in the list of agents for medical treatment of this disease there are some changes and additions every year. It is found that in the latest editions of Federal guidelines additional tradenames of therapeutic agents with more accessible forms of issuance and dosage are provided, what improves the quality of medical treatment of Parkinson’s disease and also produces a necessary degree of comfort in a usage of a medicament or in a correction of a dose.

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THE ROLE OF CERULOPLASMININ THE Α2- GLOBULIN FRACTION OF PROTEIN METABOLISM IN THE LIVER INDUCED BY CARBON TETRACHLORIDE AND ITS CORRECTION BY PHYTOCOMPOSITION №1 + PHYTOF 

Posted in 2016, Issue August 2016, PHARMACEUTICS | 0 comments

The pharmacological effect of the total extract of Phyto composition №1 + PhytoF (F№1 + PhytoF) on the functional state of hepatocytes, namely the metabolism of proteins, in comparison with the classical hepatoprotectorEssentiale forte N (EFN) and extract of Paliurusspina-christi (PSCh), which is in the composition of (F№1 + PhytoF), was studied in rabbits with liver induced by carbon tetrachloride. To this end,the complete analysis of total protein, albumin, globulin, and ceruloplasmin (CP), which is in the composition of the α2-globulin fraction as one of the main components of the antioxidant defense system and the response of the organism to stress factors, was performedand the protein coefficient was determined. The research showed thatamong the investigated proteinsin allgroups of studied animals, the pharmacological activity of F№1+PhytoF had the greatest effect on the synthesis of CP and globulin fraction content. Further, in a comparative aspect, the coefficient of variation from controls (CV) for (F№1 + F), (EPN), (PSCh) was determined by (CP),and based on the data of the changes of the protein fractions, hepatoprotective activity of the studied compounds was established.

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COMPARATIVE ANALYSIS OF THERMAL WATER USED FOR THE CARE OF SKIN

Posted in 2016, Issue August 2016, PHARMACEUTICS | 0 comments

In article the concept of thermal waters, which are extracted from underground sources and their temperature is always above ambient, and fits most 30°C. as the classification of thermal waters, used for the care of the skin depending on salinity and Ph, the comparative analysis of ion composition of the thermal water production in France and Russia. Determined the effect of these thermal waters on the skin which with constant use softens skin, possesses anti-inflammatory properties and accelerates skin regeneration.

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