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Submit scientific paper, scientific publications, International Research Journal | Meždunarodnyj naučno-issledovatel’skij žurnal

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ПИ № ФС 77 - 51217

THE COMPARATIVE ANALYSIS OF DOPAMINERGIC DRUGS, WHICH USED FOR A MEDICAL TREATMENT OF PARKINSON’S DISEASE AND WHICH INCLUDED INTO FEDERAL GUIDELINES FOR THE USE OF THERAPEUTIC AGENTS OF THE RUSSIAN FEDERATION

Posted in 2016, Issue November 2016, PHARMACEUTICS | 0 comments

The article states the comparative analysis of dopaminergic drugs, which used for a medical treatment of Parkinson’s disease and which included into Federal guidelines for the use of therapeutic agents of the Russian Federation. During the research we have analysed the section “Drugs for Parkinson’s disease treatment” in Federal guidelines for the use of therapeutic agents of the Russian Federation published in 2010, 2013, 2016. The comparative analysis of the dopaminergic drugs revealed that in the list of agents for medical treatment of this disease there are some changes and additions every year. It is found that in the latest editions of Federal guidelines additional tradenames of therapeutic agents with more accessible forms of issuance and dosage are provided, what improves the quality of medical treatment of Parkinson’s disease and also produces a necessary degree of comfort in a usage of a medicament or in a correction of a dose.

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THE ROLE OF CERULOPLASMININ THE Α2- GLOBULIN FRACTION OF PROTEIN METABOLISM IN THE LIVER INDUCED BY CARBON TETRACHLORIDE AND ITS CORRECTION BY PHYTOCOMPOSITION №1 + PHYTOF 

Posted in 2016, Issue August 2016, PHARMACEUTICS | 0 comments

The pharmacological effect of the total extract of Phyto composition №1 + PhytoF (F№1 + PhytoF) on the functional state of hepatocytes, namely the metabolism of proteins, in comparison with the classical hepatoprotectorEssentiale forte N (EFN) and extract of Paliurusspina-christi (PSCh), which is in the composition of (F№1 + PhytoF), was studied in rabbits with liver induced by carbon tetrachloride. To this end,the complete analysis of total protein, albumin, globulin, and ceruloplasmin (CP), which is in the composition of the α2-globulin fraction as one of the main components of the antioxidant defense system and the response of the organism to stress factors, was performedand the protein coefficient was determined. The research showed thatamong the investigated proteinsin allgroups of studied animals, the pharmacological activity of F№1+PhytoF had the greatest effect on the synthesis of CP and globulin fraction content. Further, in a comparative aspect, the coefficient of variation from controls (CV) for (F№1 + F), (EPN), (PSCh) was determined by (CP),and based on the data of the changes of the protein fractions, hepatoprotective activity of the studied compounds was established.

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COMPARATIVE ANALYSIS OF THERMAL WATER USED FOR THE CARE OF SKIN

Posted in 2016, Issue August 2016, PHARMACEUTICS | 0 comments

In article the concept of thermal waters, which are extracted from underground sources and their temperature is always above ambient, and fits most 30°C. as the classification of thermal waters, used for the care of the skin depending on salinity and Ph, the comparative analysis of ion composition of the thermal water production in France and Russia. Determined the effect of these thermal waters on the skin which with constant use softens skin, possesses anti-inflammatory properties and accelerates skin regeneration.

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MORPHOLOGICAL AND ANATOMICAL DIAGNOSTIC FEATURES FEVERWEED CAUCASIAN AND ERYNGIUM PLANUM

Posted in 2016, Issue July 2016, PHARMACEUTICS | 0 comments

Studied the microstructure of roots, stems and leaves of Eryngium planum and feverweed Caucasus in order to establish diagnostic features and secretory structures. The obtained results allow to identify plant material and can be used in the development of a regulatory document under the heading “Microscopy”. Essential oil tubules found in the roots, stems, petioles and leaf blades. They are located in the roots in the phloem and pericyclic zone, accompanied by vascular bundles in the aboveground organs. Branching stem in inflorescence false – dichotomy. Leaf blade dorsoventral type amfistomaticheskaya.

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COMPETITIVENESS NETWORK PHARMACY IN VELIKY NOVGOROD

Posted in 2016, Issue June 2016, PHARMACEUTICS | 0 comments

In market conditions the competitiveness of the organization is one of the important tasks of modern pharmacy. This index is examined on pharmacy chains in Veliky Novgorod. In our study, the concordance coefficient is 0.58, it indicates the consensus of expert opinions. They chose the location of pharmacy, its assortment of goods, staff qualification and the level of prices as the most important factors of the competitiveness. Based on expert opinions and survey of visitors in network pharmacies integral competitiveness index ranged from 0.915 to 0.949, it demonstrates that all three network pharmacies are sufficiently strong competitors. However, the calculation of each parameter of competitiveness from the viewpoint of buyers identified capabilities to improve the work of pharmacies.

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EFFECT OF DIFFERENT SIZED ZINC COMPOUNDS ON THE LIFTING FORCE OF THE TEST CULTURE SACCHAROMYCES CEREVISIAE

Posted in 2016, Issue May 2016, PHARMACEUTICS | 0 comments

The article presented a study of the effects of inorganic Zn compounds of various size and morphology (technical samples ZnO, Zn(OH)2 and ZnSO4, micronized by different ways ZnO samples and synthesized nanoscaled Zn(OH)2) to the lifting force of the test culture of Saccharomyces cerevisiae. High activity of slightly soluble connections when comparing with an ionic form is shown. Dependence of a biological response on morphology and dimension of the studied connections is observed.

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