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Submit scientific paper, scientific publications, International Research Journal | Meždunarodnyj naučno-issledovatel’skij žurnal

ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT), DOI: 10.18454/IRJ.2227-6017
ПИ № ФС 77 - 51217

VALIDATION OF QUANTITATIVE DETERMINATION METHOD OF CHLOROXEXIDINE BIGLUCONATE IN GEL FOR DENTINE CARIES TREATMENT

Posted in 2017, Issue № 4(58) April 2017, PHARMACEUTICS | 0 comments

The paper presents the results of validation method for quantitative determination of chlorhexidine bigluconate in gel for dentine caries treatment. Lauryl-sulfate method was proposed as a means of quantitative determination of chlorhexidine bigluconate according to precipitation titration variant. The method was evaluated by validation characteristics: Analytical field of application, linearity, accuracy and precision (convergence). As a result of the conducted studies, it was found that analytical range of application of the proposed method from 80 to 120% confirmed the linear dependence of titrant consumption on the quantitative content of chlorhexidine bigluconate, the average regeneration rate comprised 99.2%. The validated procedure allows determining quantitative content of chlorhexidine bigluconate in the presence of concomitant components and can be recommended for inclusion in regulatory documentation.

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MARKETING RESEARCH OF RUSSIAN AND REGIONAL MARKET OF MEDICINAL DRUGS APPLIED FOR TREATMENT OF ACUTE INTESTINAL INFECTIONS

Posted in 2017, Issue № 4(58) April 2017, PHARMACEUTICS | 0 comments

Acute intestinal infection (AII) is one of the most significant problems of medicine and public health in general, due to the global presence and no tendency in reduction of incidence. In order to determine meeting of the need for medicines, children suffering from acute intestinal infections, the target segment of the Russian and regional pharmaceutical market (Republic of North Ossetia-Alania) and the drugs used to treat AII, were investigated. Using the marketing analysis methods, the assortment of drugs used for the treatment of acute intestinal infections of various etiologies was studied and systematized, the saturation of the regional market compared with the all-Russian one is given as well.

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THE COMPARATIVE ANALYSIS OF DOPAMINERGIC DRUGS, WHICH USED FOR A MEDICAL TREATMENT OF PARKINSON’S DISEASE AND WHICH INCLUDED INTO FEDERAL GUIDELINES FOR THE USE OF THERAPEUTIC AGENTS OF THE RUSSIAN FEDERATION

Posted in 2016, Issue November 2016, PHARMACEUTICS | 0 comments

The article states the comparative analysis of dopaminergic drugs, which used for a medical treatment of Parkinson’s disease and which included into Federal guidelines for the use of therapeutic agents of the Russian Federation. During the research we have analysed the section “Drugs for Parkinson’s disease treatment” in Federal guidelines for the use of therapeutic agents of the Russian Federation published in 2010, 2013, 2016. The comparative analysis of the dopaminergic drugs revealed that in the list of agents for medical treatment of this disease there are some changes and additions every year. It is found that in the latest editions of Federal guidelines additional tradenames of therapeutic agents with more accessible forms of issuance and dosage are provided, what improves the quality of medical treatment of Parkinson’s disease and also produces a necessary degree of comfort in a usage of a medicament or in a correction of a dose.

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THE ROLE OF CERULOPLASMININ THE Α2- GLOBULIN FRACTION OF PROTEIN METABOLISM IN THE LIVER INDUCED BY CARBON TETRACHLORIDE AND ITS CORRECTION BY PHYTOCOMPOSITION №1 + PHYTOF 

Posted in 2016, Issue August 2016, PHARMACEUTICS | 0 comments

The pharmacological effect of the total extract of Phyto composition №1 + PhytoF (F№1 + PhytoF) on the functional state of hepatocytes, namely the metabolism of proteins, in comparison with the classical hepatoprotectorEssentiale forte N (EFN) and extract of Paliurusspina-christi (PSCh), which is in the composition of (F№1 + PhytoF), was studied in rabbits with liver induced by carbon tetrachloride. To this end,the complete analysis of total protein, albumin, globulin, and ceruloplasmin (CP), which is in the composition of the α2-globulin fraction as one of the main components of the antioxidant defense system and the response of the organism to stress factors, was performedand the protein coefficient was determined. The research showed thatamong the investigated proteinsin allgroups of studied animals, the pharmacological activity of F№1+PhytoF had the greatest effect on the synthesis of CP and globulin fraction content. Further, in a comparative aspect, the coefficient of variation from controls (CV) for (F№1 + F), (EPN), (PSCh) was determined by (CP),and based on the data of the changes of the protein fractions, hepatoprotective activity of the studied compounds was established.

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COMPARATIVE ANALYSIS OF THERMAL WATER USED FOR THE CARE OF SKIN

Posted in 2016, Issue August 2016, PHARMACEUTICS | 0 comments

In article the concept of thermal waters, which are extracted from underground sources and their temperature is always above ambient, and fits most 30°C. as the classification of thermal waters, used for the care of the skin depending on salinity and Ph, the comparative analysis of ion composition of the thermal water production in France and Russia. Determined the effect of these thermal waters on the skin which with constant use softens skin, possesses anti-inflammatory properties and accelerates skin regeneration.

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MORPHOLOGICAL AND ANATOMICAL DIAGNOSTIC FEATURES FEVERWEED CAUCASIAN AND ERYNGIUM PLANUM

Posted in 2016, Issue July 2016, PHARMACEUTICS | 0 comments

Studied the microstructure of roots, stems and leaves of Eryngium planum and feverweed Caucasus in order to establish diagnostic features and secretory structures. The obtained results allow to identify plant material and can be used in the development of a regulatory document under the heading “Microscopy”. Essential oil tubules found in the roots, stems, petioles and leaf blades. They are located in the roots in the phloem and pericyclic zone, accompanied by vascular bundles in the aboveground organs. Branching stem in inflorescence false – dichotomy. Leaf blade dorsoventral type amfistomaticheskaya.

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